Cloning and molecular analysis of geldanamycin biosynthetic genes from Streptomyces hygroscopicus

Chinese Journal of Antibiotics

Volumn 27, Issue 1, 2002, Pages 13-17+27

  Gao, Qun Jie ^a   Shang, Guang Dong ^a   Ying, Yang ^a   Sun, Gui Zhi ^a   Wang, Yi Guang ^a   Tao, Pei Zhen ^a   Lou, Zhi Xian ^a   Yao, Tian Jue ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Biosynthetic gene; Geldanamycin; Gene disruption; Genomic library

Indexed keywords

3 AMINO 5 HYDROXYBENZOIC ACID; CYSTATHIONINE GAMMA LYASE; DNA; ERYTHRONOLIDE DERIVATIVE; GELDANAMYCIN; HYDROXYBENZOIC ACID DERIVATIVE; OLEANDOMYCIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; COSMID; DRUG SYNTHESIS; ESCHERICHIA COLI; GENE DISRUPTION; GENETIC ANALYSIS; MOLECULAR CLONING; NONHUMAN; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; STREPTOMYCES HYGROSCOPICUS; THIN LAYER CHROMATOGRAPHY;

EID: 0036167508     PISSN: 10018689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Geldanamyin. 1: Structure assignment [J]
2. 7N Units in rifamycin and related antibiotics [J]
3. Biosythesis of the ansamycin antibiotic rifamycin: Deduction from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei [J]
4. A new shuttle cosmid vector, pkc505, for Streptomyces: Its use in the cloning of three different spiramycin resistance genes from a Streptomyces ambofaciens library [J]
5. Biosythesis of ansatrienin and naphthomycin identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892 [J]