Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells

FEBS Letters

Volumn 582, Issue 27, 2008, Pages 3839-3844

  Amin, Mohammed Abdullahel ^a   Matsunaga, Sachihiro ^a   Uchiyama, Susumu ^a   Fukui, Kiichi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

HeLa cell; Mitosis; Nucleophosmin; RNAi; siRNA

Indexed keywords

NUCLEOPHOSMIN; PROTEIN P53;

ARTICLE; CELL ADHESION; CELL DIVISION; CELL PROLIFERATION; CENTROMERE; CONTROLLED STUDY; DNA SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS; MITOSIS INHIBITION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; RNA INTERFERENCE;

CHROMOSOME SEGREGATION; HELA CELLS; HUMANS; KINETOCHORES; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NUCLEAR PROTEINS; RNA INTERFERENCE;

EID: 56149087648     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.10.023     Document Type: Article

References (26)

1. Azum-Gelade M.C., Noaillac-Depeyre J., Caizergues-Ferrer M., and Gas N. Cell cycle redistribution of U3 snRNA and fibrillarin. Presence in the cytoplasmic nucleolus remnant and in the prenucleolar bodies at telophase. J Cell Sci. 107 (1994) 463-475
2. Dundr M., Hebert M.D., Karpova T.S., Stanek D., Xu H., Shpargel K.B., Meier U.T., Neugebauer K.M., Matera A.G., and Misteli T. In vivo kinetics of Cajal body components. J Cell Biol. 164 (2004) 831-842
3. Kametaka A., Takagi M., Hayakawa T., Haraguchi T., Hiraoka Y., and Yoneda Y. Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins. Genes Cell 7 (2002) 1231-1242
4. Amin M.A., Matsunaga S., Ma N., Takata H., Yokoyama M., Uchiyama S., and Fukui K. Fibrillarin, a nucleolar protein, is required for normal nuclear morphology and cellular growth in HeLa cells. Biochem. Biophys. Res. Commun. 360 (2007) 320-326
5. Ma N., Matsunaga S., Takata H., Ono-Maniwa R., Uchiyama S., and Fukui K. Nucleolin functions in nucleolus formation and chromosome congression. J. Cell Sci. 120 (2007) 2091-2105
6. Schluter C., Duchrow M., Wohlenberg C., Becker M.H., Key G., Flad H.D., and Gerdes J. The cell proliferation-associated antigen of antibody Ki-67: a very large ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J. Cell Biol. 123 (1993) 513-522
7. Derenzini M., Sirri V., Trere D., and Ochs R.L. The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells. Lab. Invest. 73 (1995) 97-502
8. Mehes G., and Pajor L. Nucleolin and fibrillarin expression in stimulated lymphocytes and differentiating HL-60 cells. A flow cytometric assay. Cell Prolif. 28 (1995) 329-336
9. Maggi Jr. L.B., and Weber J.D. Nucleolar adaptation in human cancer. Cancer Investig. 23 (2005) 599-608
10. Okuwaki M., Tsujimoto M., and Nagata K. The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype. Mol. Biol. Cell 13 (2002) 2016-2030
11. Okuwaki M., Matsumoto K., Tsujimoto M., and Nagata K. Function of nucleophosmin/B23, nucleolar acidic protein, as a histone chaperone. FEBS Lett. 506 (2001) 272-276
12. Okuda M., Horn H.F., Tarapore P., Tokuyama Y., Smulian A.G., Chan P.K., Knudsen E.S., Hofmann I.A., Snyder J.D., Bove K.E., and Fukasawa K. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103 (2000) 127-140
13. Frehlick L.J., Eirin-Lopez J.M., and Ausio J. New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperons. Bioessays 29 (2007) 49-59
14. Grisendi S., Bernardi R., Rossi M., Cheng K., Khandker L., Manova K., and Pandolfi P.P. Role of nucleophosmin in embryonic development and tumorigenesis. Nature 437 (2005) 147-153
15. Grisendi S., Mecucci C., Falini B., and Pandolfi P.P. Nucleophosmin and cancer. Nat. Rev. Cancer 6 (2006) 493-505
16. Colombo E., Marine J.C., Danovi D., Falini B., and Pelicci P.G. Nucleophosmin regulates the stability and transcriptional activity of p53. Nat. Cell Biol. 4 (2002) 529-533
17. Kurki S., Peltonen K., Latonen L., Kiviharju T.M., Ojala P.M., Meek D., and Laiho M. Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 5 (2004) 465-475
18. Amin M.A., Matsunaga S., Uchiyama S., and Fukui K. Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells. Biochem. J. 415 (2008) 345-351
19. Tang Z., Sun Y., Harley S.E., Zou H., and Yu H. Human Bubl protects centromeric sister-chromatid cohesion through shugoshin during mitosis. Proc. Natl. Acad. Sci. USA 101 (2004) 18012-18017
20. Ma H., and Penderson T. Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway. Mol. Biol. Cell 18 (2007) 2630-2635
21. Uchiyama S., Kobayashi S., Takata H., Ishihara T., Hori N., Higashi T., Hayashihara K., Sone T., Higo D., Nirasawa T., Takao T., Matsunaga S., and Fukui K. Proteome analysis of human metaphase chromosomes. J. Biol. Chem. 17 (2005) 16994-17004
22. Higashi T., Matsunaga S., Isobe K., Morimoto A., Shimada T., Kataoka S., Watanabe W., Uchiyama S., Itoh K., and Fukui K. Histone H2A mobility is regulated by its tails and acetylation core histone tails. Biochem. Biophys. Res. Commun. 357 (2007) 627-632
23. Fenech M. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov. Today 7 (2002) 1128-1137
24. Yang D., Welm A., and Bishop J.M. Cell division and cell survival in the absence of surviving. Proc. Natl. Acad. Sci. USA 101 (2004) 15100-15105
25. Pinsky B.A., and Biggins S. The spindle checkpoint: tension versus attachment. Trends Cell Biol. 15 (2005) 486-493
26. Cleaved D.W., Mao Y., and Sullivan K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112 (2003) 407-421