Skeletal and cardiac myopathy in HIV-1 transgenic rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 295, Issue 4, 2008, Pages

  Pruznak, Anne M ^a   Hong Brown, Ly ^a   Lantry, Rachel ^a   She, Pengxiang ^a   Frost, Robert A ^a   Vary, Thomas C ^a   Lang, Charles H ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

3 Methylhistidine; Cytokines; Human immunodeficiency virus; Insulin like growth factor I; Protein degradation; Protein synthesis

Indexed keywords

3 METHYLHISTIDINE; ACTIN; ALANINE AMINOTRANSFERASE; AMINO ACID; ASPARTATE AMINOTRANSFERASE; CYTOKINE; FIBRINOGEN; INSULIN; LIVER PROTEIN; SOMATOMEDIN; VIRUS PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; MUSCLE PROTEIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BODY COMPOSITION; BODY WEIGHT; BONE DISEASE; CARDIAC MYOPATHY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENERGY EXPENDITURE; FEVER; GASTROCNEMIUS MUSCLE; HEART FUNCTION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSULIN RESISTANCE; LEAN BODY WEIGHT; LIVER INJURY; MALE; MUSCLE ATROPHY; MUSCLE DISEASE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SKELETAL MUSCLE; SKELETAL MYOPATHY; TRANSGENIC RAT; URINARY EXCRETION; WESTERN BLOTTING; ANIMAL; ATROPHY; BIOSYNTHESIS; BLOOD; BODY TEMPERATURE; CALORIMETRY; ENERGY METABOLISM; FISCHER 344 RAT; GENETICS; HEART MUSCLE CELL; KIDNEY; METABOLISM; NUCLEASE PROTECTION ASSAY; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC ANIMAL; WASTING SYNDROME;

AMINO ACIDS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ATROPHY; BLOTTING, NORTHERN; BODY COMPOSITION; BODY TEMPERATURE; BODY WEIGHT; CALORIMETRY, INDIRECT; CYTOKINES; ENERGY METABOLISM; HIV WASTING SYNDROME; HIV-1; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; KIDNEY; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR DISEASES; MYOCYTES, CARDIAC; NUCLEASE PROTECTION ASSAYS; ORGAN SIZE; RATS; RATS, INBRED F344;

EID: 56049120320     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90482.2008     Document Type: Article

References (59)

1. Bacchetti P, Gripshover B, Grunfeld C, Heymsfield S, McCreath H, Osmond D, Saag M, Scherzer R, Shlipak M, Tien P. Fat distribution in men with HIV infection. J Acquir Immune Defic Syndr 40: 121-131, 2005.
2. Batterham MJ. Investigating heterogeneity in studies of resting energy expenditure in persons with HIV/AIDS: a meta-analysis. Am J Clin Nutr 81: 702-713, 2005.
3. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294: 1704-1708, 2001.
4. Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277: 23977-23980, 2002.
5. Chan IS, Neaton JD, Saravolatz LD, Crane LR, Osterberger J. Frequencies of opportunistic diseases prior to death among HIV-infected persons. Community Programs for Clinical Research on AIDS. AIDS 9: 1145-1151, 1995.
6. Chaves AA, Baliga RS, Mihm MJ, Schanbacher BL, Basuray A, Liu C, Cook AC, Ayers LW, Bauer JA. Bacterial lipopolysaccharide enhances cardiac dysfunction but not retroviral replication in murine AIDS: roles of macrophage infiltration and toll-like receptor 4 expression. Am J Pathol 168: 727-735, 2006.
7. Chaves AA, Mihm MJ, Schanbacher BL, Basuray A, Liu C, Ayers LW, Bauer JA. Cardiomyopathy in a murine model of AIDS: evidence of reactive nitrogen species and corroboration in human HIV/AIDS cardiac tissues. Cardiovasc Res 60: 108-118, 2003.
8. Doring H, Schwarzer K, Nuesslein-Hildesheim B, Schmidt I. Leptin selectively increases energy expenditure of food-restricted lean mice. Int J Obes Relat Metab Disord 22: 83-88, 1998.
9. Ferrando AA, Sheffield-Moore M, Yeckel CW, Gilkison C, Jiang J, Achacosa A, Lieberman SA, Tipton K, Wolfe RR, Urban RJ. Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. Am J Physiol Endocrinol Metab 282: E601-E607, 2002.
10. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 395: 763-770, 1998.
11. Gao Q, Horvath TL. Cross-talk between estrogen and leptin signaling in the hypothalamus. Am J Physiol Endocrinol Metab 294: E817-E826, 2008.
12. Grunfeld C, Pang M, Shimizu L, Shigenaga JK, Jensen P, Feingold KR. Resting energy expenditure, caloric intake, and short-term weight change in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. Am J Clin Nutr 55: 455-460, 1992.
13. Hecker LM, Kotler DP. Malnutrition in patients with AIDS. Nutr Rev 48: 393-401, 1990.
14. Himelman RB, Chung WS, Chernoff DN, Schiller NB, Hollander H. Cardiac manifestations of human immunodeficiency virus infection: a two-dimensional echocardiographic study. J Am Coll Cardiol 13: 1030-1036, 1989.
15. Hong-Brown LQ, Pruznak AM, Frost RA, Vary TC, Lang CH. Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am J Physiol Endocrinol Metab 289: E382-E390, 2005.
16. Kline ER, Kleinhenz DJ, Liang B, Dikalov S, Guidot DM, Hart CM, Jones DP, Sutliff RL. Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. Am J Physiol Heart Circ Physiol 294: H2792-H2804, 2008.
17. Kotler DP, Tierney AR, Wang J, Pierson RN Jr. Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS. Am J Clin Nutr 50: 444-447, 1989.
18. Krawiec BJ, Frost RA, Vary TC, Jefferson LS, Lang CH. Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis. Am J Physiol Endocrinol Metab 289: E969-E980, 2005.
19. 12 cells. Am J Physiol Endocrinol Metab 292: E1555-E1567, 2007.
20. Lang CH, Bagby GJ, Dobrescu C, Nelson S, Spitzer JJ. Effect of granulocyte colony-stimulating factor on sepsis-induced changes in neutrophil accumulation and organ glucose uptake. J Infect Dis 166: 336-343, 1992.
21. Lang CH, Frost RA. Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection. Curr Opin Clin Nutr Metab Care 5: 271-279, 2002.
22. Lang CH, Frost RA. Glucocorticoids and TNFα interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle. Mol Med 12: 291-299, 2006.
23. Lang CH, Frost RA, Svanberg E, Vary TC. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am J Physiol Endocrinol Metab 286: E916-E926, 2004.
24. Lang CH, Frost RA, Vary TC. Regulation of muscle protein synthesis during sepsis and inflammation. Am J Physiol Endocrinol Metab 293: E453-E459, 2007.
25. Lang CH, Frost RA, Vary TC. Acute alcohol intoxication increases REDD1 in skeletal muscle. Alcohol Clin Exp Res 32: 796-805, 2008.
26. Lang CH, Nystrom G, Frost RA. -β-Adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor-α and interleukin-6 in skeletal muscle and is associated with impaired translation initiation. J Trauma 64: 477-486, 2008.
27. Lang CH, Wu D, Frost RA, Jefferson LS, Kimball SR, Vary TC. Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E. Am J Physiol Endocrinol Metab 277: E268-E276, 1999.
28. Lewis W. Cardiomyopathy in AIDS: a pathophysiological perspective. Prog Cardiovasc Dis 43: 151-170, 2000.
29. Lewis W, Grupp IL, Grupp G, Hoit B, Morris R, Samarel AM, Bruggeman L, Klotman P. Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine. Lab Invest 80: 187-197, 2000.
30. Macallan DC, Noble C, Baldwin C, Jebb SA, Prentice AM, Coward WA, Sawyer MB, McManus TJ, Griffin GE. Energy expenditure and wasting in human immunodeficiency virus infection. N Engl J Med 333: 83-88, 1995.
31. McNurlan MA, Garlick PJ, Steigbigel RT, Decristofaro KA, Frost RA, Lang CH, Johnson RW, Santasier AM, Cabahug CJ, Fuhrer J, Gelato MC. Responsiveness of muscle protein synthesis to growth hormone administration in HIV-infected individuals declines with severity of disease. J Clin Invest 100: 2125-2132, 1997.
32. Molina PE, Lang CH, McNurlan M, Bagby GJ, Nelson S. Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting. Alcohol Clin Exp Res 32: 138-147, 2008.
33. Molina PE, McNurlan M, Rathmacher J, Lang CH, Zambell KL, Purcell J, Bohm RP, Zhang P, Bagby GJ, Nelson S. Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infection. Alcohol Clin Exp Res 30: 2065-2078, 2006.
34. Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294: E15-E26, 2008.
35. Otis JS, Ashikhmin YI, Brown LA, Guidot DM. Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats. AIDS Res Ther 5: 8, 2008.
36. Ott M, Lembcke B, Fischer H, Jager R, Polat H, Geier H, Rech M, Staszeswki S, Helm EB, Caspary WF. Early changes of body composition in human immunodeficiency virus-infected patients: tetrapolar body impedance analysis indicates significant malnutrition. Am J Clin Nutr 57: 15-19, 1993.
37. Poizot-Martin I, Benourine K, Philibert P, Boulet JM, Badetti C, Tramier M, Vollot F, Dalmas AM, Manelli JC, Gastaut JA. Diet-induced thermogenesis in HIV infection. AIDS 8: 501-504, 1994.
38. Reid W, Abdelwahab S, Sadowska M, Huso D, Neal A, Ahearn A, Bryant J, Gallo RC, Lewis GK, Reitz M. HIV-1 transgenic rats develop T cell abnormalities. Virology 321: 111-119, 2004.
39. Reid W, Sadowska M, Denaro F, Rao S, Foulke J Jr, Hayes N, Jones O, Doodnauth D, Davis H, Sill A, O'Driscoll P, Huso D, Fouts T, Lewis G, Hill M, Kamin-Lewis R, Wei C, Ray P, Gallo RC, Reitz M, Bryant J. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc Natl Acad Sci USA 98: 9271-9276, 2001.
40. Roldan EO, Moskowitz L, Hensley GT. Pathology of the heart in acquired immunodeficiency syndrome. Arch Pathol Lab Med 111: 943-946, 1987.
41. Serrano AL, Jardi M, Suelves M, Klotman PE, Munoz-Canoves P. HIV-1 transgenic expression in mice induces selective atrophy of fast-glycolytic skeletal muscle fibers. Front Biosci 13: 2797-2805, 2008.
42. She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, Hutson SM. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab 6: 181-194, 2007.
43. Steiner AA, Romanovsky AA. Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res 46: 89-107, 2007.
44. Suttmann U, Ockenga J, Hoogestraat L, Selberg O, Schedel I, Deicher H, Muller MJ. Resting energy expenditure and weight loss in human immunodeficiency virus-infected patients. Metabolism 42: 1173-1179, 1993.
45. Suttmann U, Ockenga J, Selberg O, Hoogestraat L, Deicher H, Muller MJ. Incidence and prognostic value of malnutrition and wasting in human immunodeficiency virus-infected outpatients. J Acquir Immune Defic Syndr Hum Retrovirol 8: 239-246, 1995.
46. Tang AM, Jacobson DL, Spiegelman D, Knox TA, Wanke C. Increasing risk of 5% or greater unintentional weight loss in a cohort of HIV-infected patients, 1995 to 2003. J Acquir Immune Defic Syndr 40: 70-76, 2005.
47. Thissen JP, Underwood LE, Ketelslegers JM. Regulation of insulin-like growth factor-I in starvation and injury. Nutr Rev 57: 167-176, 1999.
48. van Maanen M, Sutton RE. Rodent models for HIV-1 infection and disease. Curr HIV Res 1: 121-130, 2003.
49. Vary TC, Frost RA, Lang CH. Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle. Am J Physiol Regul Integr Comp Physiol 294: R1777-R1789, 2008.
50. Vary TC, Kimball SR. Sepsis-induced changes in protein synthesis: differential effects on fast- and slow-twitch muscles. Am J Physiol Cell Physiol 262: C1513-C1519, 1992.
51. Vary TC, Kimball SR, Sumner A. Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption. Am J Physiol Regul Integr Comp Physiol 292: R778-R787, 2007.
52. Vary TC, Lang CH. Assessing effects of alcohol consumption on protein synthesis in striated muscles. Methods Mol Biol 447: 343-355, 2008.
53. Visnegarwala F, Shlay JC, Barry V, Gibert CL, Xiang Y, Wang J, Kotler D, Raghavan S, El-Sadr WM. Effects of HIV infection on body composition changes among men of different racial/ethnic origins. HIV Clin Trials 8: 145-154, 2007.
54. Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology 147: 4160-4168, 2006.
55. Wang Z, Heo M, Lee RC, Kotler DP, Withers RT, Heymsfield SB. Muscularity in adult humans: proportion of adipose tissue-free body mass as skeletal muscle. Am J Hum Biol 13: 612-619, 2001.
56. Wanke CA, Silva M, Knox TA, Forrester J, Speigelman D, Gorbach SL. Weight loss and wasting remain common complications in individuals infected with human immunodeficiency virus in the era of highly active antiretroviral therapy. Clin Infect Dis 31: 803-805, 2000.
57. Yadav A, Pati S, Nyugen A, Barabitskaja O, Mondal P, Anderson M, Gallo RC, Huso DL, Reid W. HIV-1 transgenic rat CD4+ T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation. Virology 353: 357-365, 2006.
58. Yarasheski KE, Smith SR, Powderly WG. Reducing plasma HIV RNA improves muscle amino acid metabolism. Am J Physiol Endocrinol Metab 288: E278-E284, 2005.
59. a and inappropriately low muscle protein synthesis rate in AIDS wasting. Am J Physiol Endocrinol Metab 275: E577-E583, 1998.