Effects of modafinil and sleep loss on physiological parameters

Military Medicine

Volumn 173, Issue 11, 2008, Pages 1092-1097

  Cuddy, John S ^a   Reinert, Andrew R ^a   Hansen, Kent C ^b   Ruby, Brent C ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MODAFINIL; PLACEBO; WATER;

AIR FORCE; ANALYTICAL PARAMETERS; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENERGY EXPENDITURE; FATIGUE; HUMAN; MALE; MILITARY MEDICINE; MOUTH TEMPERATURE; NORMAL HUMAN; OPERATOR; OUTCOME ASSESSMENT; PHYSICAL PERFORMANCE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; THERMOREGULATION; TURNOVER TIME; URINALYSIS; WAKEFULNESS; WATER METABOLISM;

EID: 56049117639     PISSN: 00264075     EISSN: None     Source Type: Journal    
DOI: 10.7205/MILMED.173.11.1092     Document Type: Article

References (31)

1. Lyons TJ, French J: Modafinil: the unique properties of a new stimulant. Aviat Space Environ Med 1991; 62: 432-5.
2. Wesensten NJ, Belenky G, Kautz MA, Thorne DR, Reichardt RM, Balkin TJ: Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine. Psychopharmacology (Berl) 2002; 159: 238-47.
3. Wesensten NJ, Killgore WD, Balkin TJ: Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation. J Sleep Res 2005; 14: 255-66.
4. Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM: Dopaminergic role in stimulant-induced wakefulness. J Neurosci 2001; 21: 1787-94.
5. Menza MA, Kaufman KR, Castellanos A: Modafinil augmentation of antidepressant treatment in depression. J Clin Psychiatry 2000; 61: 378-81.
6. Caldwell JA, Caldwell JL, Smith JK, Brown DL: Modafinil's effects on simulator performance and mood in pilots during 37 h without sleep. Aviat Space Environ Med 2004; 75: 777-84.
7. Caldwell JA Jr, Caldwell JL, Smythe NK III, Hall KK: A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology (Berl) 2000; 150: 272-82.
8. Jacobs I, Bell DG: Effects of acute modafinil ingestion on exercise time to exhaustion. Med Sci Sports Exerc 2004; 36: 1078-82.
9. McLellan TM, Ducharme MB, Canini F, et al: Effect of modafinil on core temperature during sustained wakefulness and exercise in a warm environment. Aviat Space Environ Med 2002; 73: 1079-88.
10. Brun J, Chamba G, Khalfallah Y, et al: Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation. J Sleep Res 1998; 7: 105-14.
11. Pigeau R, Naitoh P, Buguet A, et al: Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res 1995; 4: 212-28.
12. Launay JC, Besnard Y, Guinet A, Bessard G, Raphel C, Savourey G: Effects of modafinil on heat thermoregulatory responses in humans at rest. Can J Physiol Pharmacol 2002; 80: 796-803.
13. Tharion WJ, Lieberman HR, Montain SJ, et al: Energy requirements of military personnel. Appetite 2005; 44: 47-65.
14. Burstein R, Coward AW, Askew WE, et al.: Energy expenditure variations in soldiers performing military activities under cold and hot climate conditions. Milit Med 1996; 161: 750-4.
15. Castellani JW, Delany JP, O'Brien C, Hoyt RW, Santee WR, Young AJ: Energy expenditure in men and women during 54 h of exercise and caloric deprivation. Med Sci Sports Exerc 2006; 38: 894-900.
16. Forbes-Ewan CH, Morrissey BL, Gregg GC, Waters DR: Use of doubly labeled water technique in soldiers training for jungle warfare. J Appl Physiol 1989; 67: 14-8.
17. Hoyt RW, Opstad PK, Haugen AH, DeLany JP, Cymerman A, Friedl KE: Negative energy balance in male and female rangers: effects of 7 d of sustained exercise and food deprivation. Am J Clin Nutr 2006; 83: 1068-75.
18. Mudambo KS, Scrimgeour CM, Rennie MJ: Adequacy of food rations in soldiers during exercise in hot, day-time conditions assessed by doubly labelled water and energy balance methods. Eur J Appl Physiol Occup Physiol 1997; 76: 346-51.
19. Tharion WJ, Baker-Fulco CJ, Bovill ME, et al.: Adequacy of garrison feeding for Special Forces soldiers during training. Milit Med 2004; 169: 483-90.
20. Ruby BC, Schoeller DA, Sharkey BJ, Burks C, Tysk S: Water turnover and changes in body composition during arduous wildfire suppression. Med Sci Sports Exerc 2003; 35: 1760-5.
21. Leiper JB, Maughan RJ: Comparison of water turnover rates in young swimmers in training and age-matched non-training individuals. Int J Sport Nutr Exerc Metab 2004; 14: 347-57.
22. Leiper JB, Pitsiladis Y, Maughan RJ: Comparison of water turnover rates in men undertaking prolonged cycling exercise and sedentary men. Int J Sports Med 2001; 22: 181-5.
23. Schoeller DA, Colligan AS, Shriver T, Avak H, Bartok-Olson C: Use of an automated chromium reduction system for hydrogen isotope ratio analysis of physiological fluids applied to doubly labeled water analysis. J Mass Spectrom 2000; 35: 1128.
24. 2 samples by continuous-flow isotope ratio mass spectrometry. J Mass Spectrom 1997; 32: 1332-6.
25. Cole TJ, Coward WA: Precision and accuracy of doubly labeled water energy expenditure by multipoint and two-point methods. Am J Physiol 1992; 263: E965-73.
26. Racette SB, Schoeller DA, Luke AH, Shay K, Hnilicka J, Kushner RF: Relative dilution spaces of 2H- and 18O-labeled water in humans. Am J Physiol 1994; 267: E585-90.
27. Weir JB: New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949; 109: 1.
28. Ruby BC, Shriver TC, Zderic TW, Sharkey BJ, Burks C, Tysk S: Total energy expenditure during arduous wildfire suppression. Med Sci Sports Exerc 2002; 34: 1048-54.
29. VanHelder T, Radomski MW: Sleep deprivation and the effect on exercise performance. Sports Med 1989; 7: 235.
30. Baranski JV, Cian C, Esquivie D, Pigeau RA, Raphel C: Modafinil during 64 hr of sleep deprivation: dose-related effects on fatigue, alertness, and cognitive performance. Mil Psychol 1998; 10: 173-93.
31. Baranski JV, Gil V, McLellan TM, Moroz D, Buguet A, Radomski M: Effects of modafinil on cognitive performance during 40 hr of sleep deprivation in a warm environment. Mil Psychol 2002; 14: 23-47.