Cough reflex responses during pulmonary C-fibre receptor activation in anesthetized rabbits

Neuroscience Letters

Volumn 448, Issue 2, 2008, Pages 200-203

  Mutolo, Donatella ^a   Bongianni, Fulvia ^a   Cinelli, Elenia ^a   Fontana, Giovanni A ^a   Pantaleo, Tito ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cough; Phenylbiguanide; Pulmonary C fibres; Pulmonary chemoreflex; Rabbit; Respiratory reflexes

Indexed keywords

PENTOBARBITAL;

ABDOMINAL WALL MUSCULATURE; ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE REGULATION; BREATHING; BREATHING PATTERN; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; COUGHING; EXPERIMENTAL RABBIT; HEART RATE VARIABILITY; MECHANICAL STIMULATION; MUSCLE CONTRACTION; NERVE FIBER C; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; REFLEX; RESPIRATION CONTROL; TRACHEA PRESSURE; TRACHEOBRONCHIAL TREE;

ABDOMINAL MUSCLES; ANIMALS; BIGUANIDES; BLOOD PRESSURE; CATHETERIZATION; COUGH; ELECTROMYOGRAPHY; HEART RATE; MALE; MOTOR ACTIVITY; NERVE FIBERS, UNMYELINATED; PHRENIC NERVE; PULMONARY STRETCH RECEPTORS; RABBITS; REFLEX; TRACHEA;

EID: 56049116662     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.10.057     Document Type: Article

References (25)

1. Bolser D.C., Davenport P.W., Golder F.J., Baekey D., Morris K., Lindsey B., and Shannon R. Neurogenesis of cough. In: Chung F., Widdicombe J., and Boushey H. (Eds). Cough: Causes, Mechanisms and Therapy (2003), Blackwell Publishing, Oxford, UK 173-180
2. Bolser D.C., Hey J.A., and Chapman R.W. Influence of central antitussive drugs on the cough motor pattern. J. Appl. Physiol. 86 (1999) 1017-1024
3. Bolser D.C., Poliacek I., Jakus J., Fuller D.D., and Davenport P.W. Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?. Respir. Physiol. Neurobiol. 152 (2006) 255-265
4. Bongianni F., Mutolo D., Fontana G.A., and Pantaleo T. Discharge patterns of Bötzinger complex neurons during cough in the cat. Am. J. Physiol. 274 (1998) R1015-R1024
5. Bongianni F., Mutolo D., Nardone F., and Pantaleo T. Ionotropic glutamate receptors mediate excitatory drive to caudal medullary expiratory neurons in the rabbit. Brain Res. 1056 (2005) 145-157
6. Hanacek J., Tatar M., and Widdicombe J. Regulation of cough by secondary sensory inputs. Respir. Physiol. Neurobiol. 152 (2006) 282-297
7. Karczewski W., and Widdicombe J.G. The role of the vagus nerves in the respiratory and circulatory responses to intravenous histamine and phenyl diguanide in rabbits. J. Physiol. 201 (1969) 271-291
8. Kay I.S., and Armstrong D.J. Phenylbiguanide not phenyldiguanide is used to evoke the pulmonary chemoreflex in anaesthetized rabbits. Exp. Physiol. 75 (1990) 383-389
9. Korpáš J., and Tomori Z. Cough and Other Respiratory Reflexes (1979), Karger, Basel, Switzerland 1-356 pp
10. Lee L.Y., and Pisarri T.E. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir. Physiol. 125 (2001) 47-65
11. Mutolo D., Bongianni F., Carfi M., and Pantaleo T. Respiratory changes induced by kainic acid lesions in rostral ventral respiratory group of rabbits. Am. J. Physiol. 283 (2002) R227-R242
12. Mutolo D., Bongianni F., Cinelli E., Fontana G.A., and Pantaleo T. Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 (2008) R243-R251
13. Mutolo D., Bongianni F., Fontana G.A., and Pantaleo T. The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbit. Brain Res. Bull. 74 (2007) 284-293
14. Mutolo D., Bongianni F., Nardone F., and Pantaleo T. Respiratory responses evoked by blockades of ionotropic glutamate receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit. Eur. J. Neurosci. 21 (2005) 122-134
15. Mutolo D., Bongianni F., and Pantaleo T. Effects of lignocaine blockades and kainic acid lesions in the Bötzinger complex on spontaneous expiratory activity and cough reflex responses in the rabbit. Neurosci. Lett. 332 (2002) 175-179
16. Pantaleo T., Bongianni F., and Mutolo D. Central nervous mechanisms of cough. Pulm. Pharmacol. Ther. 15 (2002) 227-233
17. Shannon R., Baekey D.M., Morris K.F., Li Z., and Lindsey B.G. Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat. J. Physiol. 525 (2000) 207-224
18. Shannon R., Baekey D.M., Morris K.F., Nuding S.C., Segers L.S., and Lindsey B.G. Production of reflex cough by brainstem respiratory networks. Pulm. Pharmacol. Ther. 17 (2004) 369-376
19. Tatar M., Hanacek J., and Widdicombe J. The expiration reflex from the trachea and bronchi. Eur. Respir. J. 31 (2007) 385-390
20. Tatar M., Nagyova B., and Widdicombe J.G. Veratrine-induced reflexes and cough. Respir. Med. 85 Suppl. A (1991) 51-55
21. Tatar M., Sant'Ambrogio G., and Sant'Ambrogio F.B. Laryngeal and tracheobronchial cough in anesthetized dogs. J. Appl. Physiol. 76 (1994) 2672-2679
22. Tatar M., Webber S.E., and Widdicombe J.G. Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats. J. Physiol. 402 (1988) 411-420
23. Tomori Z., and Widdicombe J.G. Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of the respiratory tract. J. Physiol. 200 (1969) 25-49
24. Trenchard D., Russell N.J., and Raybould H.E. Non-myelinated vagal lung receptors and their reflex effects on respiration in rabbits. Respir. Physiol. 55 (1984) 63-79
25. Widdicombe J., and Singh V. Physiological and pathophysiological down-regulation of cough. Respir. Physiol. Neurobiol. 150 (2006) 105-117