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The metal-catalyzed intermolecular cyclization of P-OH to alkynes has been reported: (a) Peng, A.-Y.; Ding, Y.-X. J. Am. Chem. Soc. 2003, 125, 15006.
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The metal-catalyzed intermolecular cyclization of P-OH to alkynes has been reported: (a) Peng, A.-Y.; Ding, Y.-X. J. Am. Chem. Soc. 2003, 125, 15006.
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94
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59949098590
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We also examined the base-mediated cyclization reaction of phenyl-(2-phenylethynylphenyl)phosphine. The reaction gave the corresponding benzo[b]phosphole in 54% isolated yield together with its oxide in 12% yield
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We also examined the base-mediated cyclization reaction of phenyl-(2-phenylethynylphenyl)phosphine. The reaction gave the corresponding benzo[b]phosphole in 54% isolated yield together with its oxide in 12% yield.
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95
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59949104309
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16d We found the reaction time depends on the substrate. For example, the reaction of 2d proceeded with ca. 50% conversion for 7 h, but the reaction of 4 completes in 2 h.
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16d We found the reaction time depends on the substrate. For example, the reaction of 2d proceeded with ca. 50% conversion for 7 h, but the reaction of 4 completes in 2 h.
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96
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59949089350
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31P NMR spectra.
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31P NMR spectra.
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97
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59949087161
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31P NMR. See Supporting Information.
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31P NMR. See Supporting Information.
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98
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59949096214
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The isomer ratio could not be estimated because of the overlap of the NMR chemical shifts. An attempt to separate these isomers from each other using chromatography also failed
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The isomer ratio could not be estimated because of the overlap of the NMR chemical shifts. An attempt to separate these isomers from each other using chromatography also failed.
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