Epigallocatechin gallate (EGCG) suppresses β-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3β activation

Neurobiology of Aging

Volumn 30, Issue 1, 2009, Pages 81-92

  Lin, Chih Li ^a   Chen, Ta Fu ^b   Chiu, Ming Jang ^b   Way, Tzong Der ^a   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

amyloid; ( ) Epigallocatechin gallate; c Abl; FE65; Glycogen synthase kinase 3

Indexed keywords

ABELSON KINASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN FE65;

AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMYLOID BETA-PROTEIN; APOPTOSIS; CATECHIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-ABL;

EID: 56049095730     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.05.012     Document Type: Article

References (35)

1. Alvarez A.R., Sandoval P.C., Leal N.R., Castro P.U., and Kosik K.S. Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species. Neurobiol. Dis. 17 2 (2004) 326-336
2. Blass J.P. Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities. Neurobiol. Aging 23 6 (2002) 1077-1084
3. Buxbaum J.D., Liu K.N., Luo Y., Slack J.L., Stocking K.L., Peschon J.J., Johnson R.S., Castner B.J., Cerretti D.P., and Black R.A. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273 43 (1998) 27765-27767
4. Choi Y.T., Jung C.H., Lee S.R., Bae J.H., Baek W.K., Suh M.H., Park J., Park C.W., and Suh S.I. The green tea polyphenol (-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons. Life Sci. 70 5 (2001) 603-614
5. Dai Q., Borenstein A.R., Wu Y., Jackson J.C., and Larson E.B. Fruit and vegetable juices and Alzheimer's disease: the Kame Project. Am. J. Med. 119 9 (2006) 751-759
6. De Felice, F.G., Wu, D., Lambert, M.P., Fernandez, S.J., Velasco, P.T., Lacor, P.N., Bigio, E.H., Jerecic, J., Acton, P.J., Shughrue, P.J., Chen-Dodson, E., Kinney, G.G., Klein, W.L. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Abeta oligomers. Neurobiol. Aging, doi:10.1016/j.neurobiolaging.2007.02.09, in press.
7. Drachman D.A. Aging of the brain, entropy, and Alzheimer disease. Neurology 67 8 (2006) 1340-1352
8. Esposito E., Rotilio D., Di Matteo V., Di Giulio C., Cacchio M., and Algeri S. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol. Aging 23 5 (2002) 719-735
9. Floyd R.A., and Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 23 5 (2002) 795-807
10. Hardy J.A., and Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256 5054 (1992) 184-185
11. Hong M., Chen D.C., Klein P.S., and Lee V.M. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J. Biol. Chem. 272 40 (1997) 25326-25332
12. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., and Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274 5284 (1996) 99-102
13. Iqbal K., and Grundke-Iqbal I. Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective. J. Alzheimers Dis. 9 Suppl. 3 (2006) 219-242
14. Lau K.F., Miller C.C., Anderton B.H., and Shaw P.C. Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter. Genomics 60 2 (1999) 121-128
15. Levites Y., Amit T., Mandel S., and Youdim M.B. Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J. 17 8 (2003) 952-954
16. Lovestone S., Hartley C.L., Pearce J., and Anderton B.H. Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: the effects on the organization and stability of microtubules. Neuroscience 73 4 (1996) 1145-1157
17. Ma Q.L., Lim G.P., Harris-White M.E., Yang F., Ambegaokar S.S., Ubeda O.J., Glabe C.G., Teter B., Frautschy S.A., and Cole G.M. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J. Neurosci. Res. 83 3 (2006) 374-384
18. Mandel S., Amit T., Reznichenko L., Weinreb O., and Youdim M.B. Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. Mol. Nutr. Food Res. 50 2 (2006) 229-234
19. Mandel S., Reznichenko L., Amit T., and Youdim M.B. Green tea polyphenol (-)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal independent of P13-Akt pathway. Neurotox. Res. 5 6 (2003) 419-424
20. Miranda S., Opazo C., Larrondo L.F., Munoz F.J., Ruiz F., Leighton F., and Inestrosa N.C. The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease. Prog. Neurobiol. 62 6 (2000) 633-648
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 1-2 (1983) 55-63
22. Munoz-Montano J.R., Moreno F.J., Avila J., and az-Nido J. Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. FEBS Lett. 411 23 (1997) 183-188
23. Nakaya T., and Suzuki T. Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes Cells 11 6 (2006) 633-645
24. Obregon D.F., Rezai-Zadeh K., Bai Y., Sun N., Hou H., Ehrhart J., Zeng J., Mori T., Arendash G.W., Shytle D., Town T., and Tan J. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. J. Biol. Chem. 281 24 (2006) 16419-16427
25. Perkinton M.S., Standen C.L., Lau K.F., Kesavapany S., Byers H.L., Ward M., McLoughlin D.M., and Miller C.C. The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling. J. Biol. Chem. 279 21 (2004) 22084-22091
26. Rezai-Zadeh K., Shytle D., Sun N., Mori T., Hou H., Jeanniton D., Ehrhart J., Townsend K., Zeng J., Morgan D., Hardy J., Town T., and Tan J. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J. Neurosci. 25 38 (2005) 8807-8814
27. Sabo S.L., Lanier L.M., Ikin A.F., Khorkova O., Sahasrabudhe S., Greengard P., and Buxbaum J.D. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J. Biol. Chem. 274 12 (1999) 7952-7957
28. Selkoe D.J. Alzheimer disease: mechanistic understanding predicts novel therapies. Ann. Intern. Med. 140 8 (2004) 627-638
29. Sinha S., and Lieberburg I. Cellular mechanisms of beta-amyloid production and secretion. Proc. Natl. Acad. Sci. U.S.A. 96 20 (1999) 11049-11053
30. Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F., and Kowall N. Oxidative damage in Alzheimer's. Nature 382 6587 (1996) 120-121
31. Sopher B.L., Fukuchi K., Smith A.C., Leppig K.A., Furlong C.E., and Martin G.M. Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein. Brain Res. Mol. Brain Res. 26 1-2 (1994) 207-217
32. Suganuma M., Okabe S., Oniyama M., Tada Y., Ito H., and Fujiki H. Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis 19 10 (1998) 1771-1776
33. Takashima A. GSK-3 is essential in the pathogenesis of Alzheimer's disease. J. Alzheimers Dis. 9 Suppl. 3 (2006) 309-317
34. Van Etten R.A. Cycling, stressed-out and nervous: cellular functions of c-Abl. Trends Cell Biol. 9 5 (1999) 179-186
35. Wang J.Y. Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress. Cell Res. 15 1 (2005) 43-48