Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantation

Transplant Immunology

Volumn 20, Issue 1-2, 2008, Pages 61-67

  Ho, E K ^a   Vasilescu, E R ^a   Colovai, A I ^a   Stokes, M B ^a   Hallar, M ^a   Markowitz, G S ^a   D'Agati, V D ^a   Cohen, D J ^a   Ratner, L E ^a   Suciu Foca, N ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Acute Antibody Mediated Rejection (AAMR); Anti HLA antibodies; Cross match

Indexed keywords

ADULT; ARTICLE; B LYMPHOCYTE; BIOPSY; COMPLEMENT DEPENDENT CYTOTOXICITY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; FLOW CYTOMETRY; GRAFT FAILURE; HUMAN; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; PRIORITY JOURNAL; SEROLOGY; T LYMPHOCYTE;

ADRENAL CORTEX HORMONES; ADULT; AGED; CADAVER; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTOCOMPATIBILITY TESTING; HUMANS; IMMUNOSUPPRESSION; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; TACROLIMUS;

EID: 56049086080     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2008.09.013     Document Type: Article

References (50)

1. Kissmeyer-Nielsen F., Olsen S., Petersen V.P., and Fjeldborg O. Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells. Lancet 2 7465 (1966) 662-665
2. Patel R., and Terasaki P.I. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 280 14 (1969) 735-739
3. Hardy M., Suciu-Foca N., McKiernan T., Rohowsky C., Cianci J., Jacob J., et al. The development and specificity of anti-B-cell antibodies during humoral rejection of kidney allografts. Transplant Proc 11 1 (1979) 389-392
4. Jackson A.M., and Zachary A.A. The problem of transplanting the sensitized patient: whose problem is it?. Front Biosci 13 (2008) 1396-1412
5. Kerman R.H. Understanding the sensitized patient. Heart Fail Clin 3 1 (2007) 1-9
6. Jordan S.C., and Pescovitz M.D. Presensitization: the problem and its management. Clin J Am Soc Nephrol 1 3 (2006) 421-432
7. Zeevi A., Girnita A., and Duquesnoy R. HLA antibody analysis: sensitivity, specificity, and clinical significance in solid organ transplantation. Immunol Res 36 1-3 (2006) 255-264
8. Tinckam K.J., and Chandraker A. Mechanisms and role of HLA and non-HLA alloantibodies. Clin J Am Soc Nephrol 1 3 (2006) 404-414
9. Suciu-Foca N., Reed E., D'Agati V.D., Ho E., Cohen D.J., Benvenisty A.I., et al. Soluble HLA antigens, anti-HLA antibodies, and antiidiotypic antibodies in the circulation of renal transplant recipients. Transplantation 51 3 (1991) 593-601
10. Suciu-Foca N., Reed E., Marboe C., Harris P., Yu P.X., Sun Y.K., et al. The role of anti-HLA antibodies in heart transplantation. Transplantation 51 3 (1991) 716-724
11. Vasilescu E.R., Ho E.K., Colovai A.I., Vlad G., Foca-Rodi A., Markowitz G.S., et al. Alloantibodies and the outcome of cadaver kidney allografts. Hum Immunol 67 8 (2006) 597-604
12. Vaidya S. Clinical importance of anti-human leukocyte antigen-specific antibody concentration in performing calculated panel reactive antibody and virtual crossmatches. Transplantation 85 7 (2008) 1046-1050
13. Karpinski M., Rush D., Jeffery J., Exner M., Regele H., Dancea S., et al. Flow cytometric crossmatching in primary renal transplant recipients with a negative anti-human globulin enhanced cytotoxicity crossmatch. J Am Soc Nephrol 12 12 (2001) 2807-2814
14. Racusen L.C., Colvin R.B., Solez K., Mihatsch M.J., Halloran P.F., Campbell P.M., et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 3 6 (2003) 708-714
15. Bristow R.E., Duska L.R., Lambrou N.C., Fishman E.K., O'Neill M.J., Trimble E.L., et al. A model for predicting surgical outcome in patients with advanced ovarian carcinoma using computed tomography. Cancer 89 7 (2000) 1532-1540
16. Hellstrom K.E., and Hellstrom I. Immunologic defenses against cancer. Immunobiology Edited by Robert A Good and David W Fisher Sinauer Assoc. Inc. Publ., Stamford, Connecticut (1971) 209-220 Chapter 21
17. Crew R.J., and Ratner L.E. Overcoming immunologic incompatibility: transplanting the difficult to transplant patient. Sem Dial 18 6 (2005) 474-481
18. Akalin E., Dinavahi R., Friedlander R., Ames S., de Boccardo G., Sehgal V., et al. Addition of plasmapheresis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodies. Clin J Am Soc Nephrol 3 4 (2008) 1160-1167
19. Kayler L.K., Farber J.L., Colombe B., LaCava D., Friedewald J.J., and Ratner L.E. Characterization of rejection episodes in patients following positive crossmatch and ABO-incompatible live donor renal transplantation. Transpl Int 19 2 (2006) 128-139
20. Reed E., Hardy M., Benvenisty A., Lattes C., Brensilver J., McCabe R., et al. Effect of antiidiotypic antibodies to HLA on graft survival in renal-allograft recipients. N Engl J Med 316 23 (1987) 1450-1455
21. Liu Z., Colovai A.I., Tugulea S., Reed E.F., Fisher P.E., Mancini D., et al. Indirect recognition of donor HLA-DR peptides in organ allograft rejection. J Clin Invest 98 5 (1996) 1150-1157
22. Ciubotariu R., Liu Z., Colovai A.I., Ho E., Itescu S., Ravalli S., et al. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts. J Clin Invest 101 2 (1998) 398-405
23. Hirsch H.H., Knowles W., Dickenmann M., Passweg J., Klimkait T., Mihatsch M.J., et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 347 7 (2002) 488-496
24. Dall A., and Hariharan S. BK virus nephritis after renal transplantation. Clin J Am Soc Nephrol 3 Suppl 2 (2008) S68-S75
25. Falk J.A., Cardella C.J., Halloran P.F., Bear R.A., and Arbus G.S. Graft outcome in the multiple transplant patient with a positive donor cross-match with non-current sera. Transplant Proc 19 1 Pt 1 (1987) 721-722
26. Goeken N.E. Outcome of renal transplantation following a positive cross-match with historical sera: the ASHI survey. Hum Immunol 14 2 (1985) 77-85
27. Leavey S.F., Walshe J.J., O'Neill D., Atkins N., Donohoe J., Hickey D., et al. Renal transplantation performed across a positive crossmatch: a single centre experience. Ir J Med Sci 166 4 (1997) 245-248
28. Lenaers J.I., Christiaans M.H., Voorter C.E., van Hooff H.P., and van den Berg-Loonen E.M. Relevance of posttransplant flow cytometric T- and B-cell crossmatches in tacrolimus-treated renal transplant patients. Transplantation 82 9 (2006) 1142-1147
29. Bryan C.F., Wakefield M., Reese J.C., Shield III C.F., Warady B.A., Winklhofer F.T., et al. Renal graft survival is not influenced by a positive flow B-cell crossmatch. Clin Transplant 21 1 (2007) 72-79
30. Gupta A., Iveson V., Varagunam M., Bodger S., Sinnott P., and Thuraisingham R.C. Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: are they relevant?. Transplantation 85 8 (2008) 1200-1204
31. van den Berg-Loonen E.M., Billen E.V., Voorter C.E., van Heurn L.W., Claas F.H., van Hooff J.P., et al. Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients. Transplantation 85 8 (2008) 1086-1090
32. Delgado J.C., and Eckels D.D. Positive B-cell only flow cytometric crossmatch: implications for renal transplantation. Exp Mol Pathol 85 1 (2008) 59-63
33. Collaborative Transplant Study Newsletter 2:2007, University of Heidelberg, www.ctstransplant.org, last accessed May 1, 2007.
34. Collaborative Transplant Study Newsletter 3:2008, University of Heidelberg, www.ctstransplant.org, last accessed August 1, 2008.
35. El-Awar N., Lee J., and Terasaki P.I. HLA antibody identification with single antigen beads compared to conventional methods. Hum Immunol 66 9 (2005) 989-997
36. El-Awar N., Lee J.H., Tarsitani C., and Terasaki P.I. HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Hum Immunol 68 3 (2007) 170-180
37. Lungu O., Reed E., Smith C., Rose E., Marboe C., Hardy M., et al. Immunological monitoring of heart allograft recipients. Transplant Proc 19 1 Pt 3 (1987) 2548-2550
38. Suciu-Foca N., McManus P., Ho E., Reed E., Benvenisty A., Hardy M., et al. Anti-HLA antibodies in recipients of renal allografts. Transplant Proc 21 1 Pt 1 (1989) 754-755
39. Cherry R., Nielsen H., Reed E., Reemtsma K., Suciu-Foca N., and Marboe C.C. Vascular (humoral) rejection in human cardiac allograft biopsies: relation to circulating anti-HLA antibodies. J Heart Lung Transplant 11 1 Pt 1 (1992) 24-29 discussion 30
40. Bian H., Harris P.E., Mulder A., and Reed E.F. Anti-HLA antibody ligation to HLA class I molecules expressed by endothelial cells stimulates tyrosine phosphorylation, inositol phosphate generation, and proliferation. Hum Immunol 53 1 (1997) 90-97
41. Harris P.E., Bian H., and Reed E.F. Induction of high affinity fibroblast growth factor receptor expression and proliferation in human endothelial cells by anti-HLA antibodies: a possible mechanism for transplant atherosclerosis. J Immunol 159 11 (1997) 5697-5704
42. Bian H., and Reed E.F. Alloantibody-mediated class I signal transduction in endothelial cells and smooth muscle cells: enhancement by IFN-gamma and TNF-alpha. J Immunol 163 2 (1999) 1010-1018
43. Bian H., and Reed E.F. Anti-HLA class I antibodies transduce signals in endothelial cells resulting in FGF receptor translocation, down-regulation of ICAM-1 and cell proliferation. Transplant Proc 33 1-2 (2001) 311
44. Jindra P.T., Zhang X., Mulder A., Claas F., Veale J., Jin Y.P., et al. Anti-HLA antibodies can induce endothelial cell survival or proliferation depending on their concentration. Transplantation 82 1 Suppl (2006) S33-35
45. Terasaki P.I. Humoral theory of transplantation. Am J Transplant 3 6 (2003) 665-673
46. Einecke G., Reeve J., Mengel M., Sis B., Bunnag S., Mueller T.F., et al. Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts. Am J Transplant 8 7 (2008) 1434-1443
47. Mueller T.F., Einecke G., Reeve J., Sis B., Mengel M., Jhangri G.S., et al. Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant 7 12 (2007) 2712-2722
48. Hidalgo L.G., Einecke G., Allanach K., Mengel M., Sis B., Mueller T.F., et al. The transcriptome of human cytotoxic T cells: measuring the burden of CTL-associated transcripts in human kidney transplants. Am J Transplant 8 3 (2008) 637-646
49. Vlad G., Ho E.K., Vasilescu E.R., Fan J., Liu Z., Cai J.W., et al. Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. Transpl Immunol 18 1 (2007) 13-21
50. Cortesini R., and Suciu-Foca N. The concept of "partial" clinical tolerance. Transpl Immunol 13 2 (2004) 101-104