BK virus nephritis after renal transplantation

Clinical Journal of the American Society of Nephrology

Volumn 3, Issue SUPPL. 2, 2008, Pages

  Dall, Aaron ^a   Hariharan, Sundaram ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BK VIRUS; HUMAN; KIDNEY TRANSPLANTATION; NEPHRITIS; POSTOPERATIVE COMPLICATION; REVIEW; RISK FACTOR; VIROLOGY; VIRUS INFECTION;

BK VIRUS; HUMANS; KIDNEY TRANSPLANTATION; NEPHRITIS; POLYOMAVIRUS INFECTIONS; POSTOPERATIVE COMPLICATIONS; RISK FACTORS; TUMOR VIRUS INFECTIONS;

EID: 41749121023     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.02770707     Document Type: Article

References (70)

1. Gardner SD, Field AM, Coleman DV, Hulme B: New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1: 1253-1257, 1971
2. Purighalla R, Shapiro R, McCauley J, Randhawa P: BK virus infection in a kidney allograft diagnosed by needle biopsy. Am J Kidney Dis 26: 671-673, 1995
3. Binet I, Nickeleit V, Hirsch HH, Prince O, Dalquen P, Gudat F, Mihatsch MJ, Thiel G: Polyomavirus disease under new immunosuppressive drugs: A cause of renal graft dysfunction and graft loss. Transplantation 67: 918-922, 1999
4. Ahuja M, Cohen EP, Dayer AM, Kampalath B, Chang CC, Bresnahan BA, Hariharan S: Polyoma virus infection after renal transplantation: Use of immunostaining as a guide to diagnosis. Transplantation 71: 896-899, 2001
5. Hirsch HH: Polyomavirus BK nephropathy: A (re-)emerging complication in renal transplantation. Am J Transplant 2: 25-30, 2002
6. Hussain S, Bresnahan BA, Cohen EP, Hariharan S: Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agents. Clin Transplant 16: 43-47, 2002
7. Mathur VS, Olson JL, Darragh TM, Yen TS: Polyomavirus-induced interstitial nephritis in two renal transplant recipients: Case reports and review of the literature. Am J Kidney Dis 29: 754-758, 1997
8. Randhawa PS, Finkelstein S, Scantlebury V, Shapiro R, Vivas C, Jordan M, Picken MM, Demetris AJ: Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 67: 103-109, 1999
9. Hariharan S: BK virus nephritis after renal transplantation. Kidney Int 69: 655-662, 2006
10. Prosser S, Hariharan S: Pathogenesis of BK virus infection after renal transplantation. Exp Rev Clin Immunol 2: 833-837, 2006
11. Rahamimov R, Lustig S, Tovar A, Yussim A, Bar-Nathan N, Shaharabani E, Boner J, Shapira Z, Mor E: BK polyoma virus nephropathy in kidney transplant recipient: The role of new immunosuppressive agents. Transplant Proc 35: 604-605, 2003
12. Shi Y, Moriyama T, Namba Y, Yamanaka M, Hanafuse T, Imamura R, Ichimaru N, Oka K, Kyo M, Tian Y, Takahara S, Ichikawa S, Okuyama A: Association of treatment with 15-deoxyspergualin and BK virus nephropathy in kidney allograft recipients. Clin Transplant 21: 502-509, 2007
13. Lipshutz GS, Flechner SM, Govani MV, Vincenti F: BK nephropathy in kidney transplant recipients treated with a calcineurin inhibitor-free immunosuppression regimen. Am J Transplant 4: 2132-2134, 2004
14. Brennan DC, Agha I, Bohl DL, Schnitzler MA, Hardinger KL, Lockwood M, Torrence S, Schuessler R, Roby T, Gaudreault-Keener M, Storch GA: Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 5: 582-594, 2005
15. Meier-Kriesche HU, Li S, Gruessner RW, Fung JJ, Bustami RT, Barr ML, Leichtman AB: Immunosuppression: Evolution in practice and trends, 1994-2004. Am J Transplant 6: 1111-1131, 2006
16. Comoli P, Azzi A, Maccario R, Basso S, Botti G, Basile G, Fontana I, Labirio M, Cometa A, Poli F, Perfumo F, Locatelli F, Ginevri F: Polyomavirus BK-specific immunity after kidney transplantation. Transplantation 78: 1229-1232, 2004
17. Prosser SE, Orentas RJ, Jurgens L, Cohen EP, Hariharan S: Recovery of BKV large T antigen-specific cellular immune response correlates with resolution of BKV nephritis. Transplantation 2008, in press
18. Binggeli S, Egli A, Schaub S, Binet I, Mayr M, Steiger J, Hirsch HH: Polyomavirus BK-specific cellular immune response to VP1 and large T-antigen in kidney transplant recipients. Am J Transplant 7: 1131-1139, 2007
19. Chen Y, Trofe J, Gordon J, Du Pasquier RA, Roy-Chaudhury P, Kuroda MJ, Woodle ES, Khalili K, Koralnik IJ: Interplay of cellular and humoral immune responses against BK virus in kidney transplant recipients with polyomavirus nephropathy. J Virol 80: 3495-3505, 2006
20. Krymskaya L, Sharma MC, Martinez J, Haq W, Huang EC, Limaye AP, Diamond DJ, Lacey SF: Cross-reactivity of T lymphocytes recognizing a human cytotoxic T-lymphocyte epitope within BK and JC virus VP1 polypeptides. J Virol 79: 11170-11178, 2005
21. Leuenberger D, Andresen PA, Gosert R, Binggeli S, Strom EH, Bodaghi S, Rinaldo CH, Hirsch HH: Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored. Clin Vaccine Immunol 14: 959-968, 2007
22. Lukacher AE, Wilson CS: Resistance to polyoma virus-induced tumors correlates with CTL recognition of an immunodominant H-2Dk-restricted epitope in the middle T protein. J Immunol 160: 1724-1734, 1998
23. Li J, Melenhorst J, Hensel N, Rezvani K, Sconocchia G, Kilical Y, Hou J, Curfman B, Major E, Barrett AJ: T-cell responses to peptide fragments of the BK virus T antigen: Implications for cross-reactivity of immune response to JC virus. J Gen Virol 87: 2951-2960, 2006
24. Randhawa PS, Popescu I, Macedo C, Zeevi A, Shapiro R, Vats AN, Metes D: Detection of CD8+ T cells sensitized to BK virus large T antigen in healthy volunteers and kidney transplant recipients. Hum Immunol 67: 298-302, 2006
25. Provenzano M, Bracci L, Wyler S, Hudolin T, Sais G, Gosert R, Zajac P, Palu' G, Heberer M, Hirsch HH, Spagnoli GC: Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A 0201 + BKV-seropositive donors. J Transl Med 4: 47, 2006
26. Bohl DL, Storch GA, Ryschkewitsch C, Gaudreault-Keener M, Schnitzler MA, Major EO, Brennan DC: Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. Am J Transplant 5: 2213-2221, 2005
27. Smith JM, McDonald RA, Finn LS, Healey PJ, Davis CL, Limaye AP: Polyomavirus nephropathy in pediatric kidney transplant recipients. Am J Transplant 4: 2109-2117, 2004
28. Ginevri F, De Santis R, Comoli P, Pastorino N, Rossi C, Botti G, Fontana I, Nocera A, Cardillo M, Ciardi MR, Locatelli F, Maccario R, Perfumo F, Azzi A: Polyomavirus BK infection in pediatric kidney-allograft recipients: A single-center analysis of incidence, risk factors, and novel therapeutic approaches. Transplantation 75: 1266-1270, 2003
29. Awadalla Y, Randhawa P, Ruppert K, Zeevi A, Duquesnoy RJ: HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients. Am J Transplant 4: 1691-1696, 2004
30. Lee EDH, Wang J, Dong Y, Lukacher AE, Newell KA, Pearson TC, Larsen CP: Inability to clear polyoma virus in MHC disparate murine kidney transplant model results in accelerated graft rejection [Abstract]. Am J Kidney Dis 4[Suppl 8]: 599, 2004
31. Drachenberg CB, Papadimitriou JC, Mann D, Hirsch HH, Wali R, Ramos E: Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy. Transplantation 80: 276-278, 2005
32. Eash S, Querbes W, Atwood WJ: Infection of vero cells by BK virus is dependent on caveolae. J Virol 78: 11583-11590, 2004
33. Moriyama T, Marquez JP, Wakatsuki T, Sorokin A: Caveolar endocytosis is critical for BK virus infection of human renal proximal tubular epithelial cells. J Virol 81: 8552-8562, 2007
34. Nickeleit V, Klimkait T, Binet IF, Dalquen P, Del Zenero V, Thiel G, Mihatsch MJ, Hirsch HH: Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. N Engl J Med 342: 1309-1315, 2000
35. Drachenberg CB, Beskow CO, Cangro CB, Bourquin PM, Simsir A, Fink J, Weir MR, Klassen DK, Bartlett ST, Papadimitriou JC: Human polyoma virus in renal allograft biopsies: Morphological findings and correlation with urine cytology. Hum Pathol 30: 970-977, 1999
36. Gupta M, Miller F, Nord EP, Wadhwa NK: Delayed renal allograft dysfunction and cystitis associated with human polyomavirus (BK) infection in a renal transplant recipient: A case report and review of literature. Clin Nephrol 60: 405-414, 2003
37. Petrogiannis-Haliotis T, Sakoulas G, Kirby J, Koralnik I, Dvorak A, Monahan-Earley R, DeGirolami P, DeGirolami U, Upton M, Major E, Pfister L, Joseph J: BK-related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med 345: 1250-1255, 2001
38. Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, Mihatsch MJ, Steiger J: Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 347: 488-496, 2002
39. Hirsch HH, Brennan DC, Drachenberg CB, Ginevri F, Gordon J, Limaye AP, Mihatsch MJ, Nickeleit V, Ramos E, Randhawa P, Shapiro R, Steiger J, Suthanthiran M, Trofe J: Polyomavirus-associated nephropathy in renal transplantation: Interdisciplinary analyses and recommendations. Transplantation 79: 1277-1286, 2005
40. Ding R, Medeiros M, Dadhania D, Muthukumar T, Kracker D, Kong JM, Epstein SR, Sharma VK, Seshan SV, Li B, Suthanthiran M: Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine. Transplantation 74: 987-994, 2002
41. Limaye AP, Smith KD, Cook L, Groom DA, Hunt NC, Jerome KR, Boeckh M. Polyoma virus nephropathy in native kidneys of non renal transplant recipients. Am J Transplant 5: 614-620, 2005
42. Drachenberg CB, Papadimitriou JC, Hirsch HH, Wali R, Crowder C, Nogueira J, Cangro CB, Mendley S, Mian A, Ramos E: Histologic patterns of polyomavirus nephropathy: Correlation with graft outcome and viral load. Am J Transplant 4: 2082-2092, 2004
43. Bracamonte E, Leca N, Smith KD, Nicosia RF, Nickeleit V, Kendrick E, Furmanczyk PS, Davis CL, Alpers CE, Kowalewska J: Tubular basement membrane immune deposits in association with BK polyomavirus nephropathy. Am J Transplant 7: 1552-1560, 2007
44. Ang DC, Rodriguez Urrego PA, Pai D, Malik A, Swannick C, Mann R, Lim J, Fyfe B: Incidence and pattern of C4d staining in renal allograft biopsies with polyoma virus nephropathy [Abstract]. Am J Transplant 7[Suppl 2]: 541, 2007
45. Boratynska M, Dubinski B, Rybka K, Jezior D, Szyber P, Klinger M: Immunocytological urinalysis and monocyte chemotactic peptide-1 in renal transplant recipients with polyomavirus replication. Transplant Proc 38: 151-154, 2006
46. Ozdemir BH, Aksoy PK, Haberal AN, Demirhan B, Haberal M: Relationship of HLA-DR expression to rejection and mononuclear cell infiltration in renal allograft biopsies. Ren Fail 26: 247-251, 2004
47. Gonzalez-Posacla JM, Garcia-Castro MC, Tamajon LP, Torres A, Hernandez D, Losada M, Maceira B, Salido E: HLA-DR class II and ICAM-1 expression on tubular cells taken by fine-needle aspiration biopsy in renal allograft dysfunction. Nephrol Dial Transplant 11: 148-152, 1996
48. Celik B, Shapiro R, Vats A, Randhawa PS: Polyomavirus allograft nephropathy: Sequential assessment of histologic viral load, tubulitis, and graft function following changes in immunosuppression. Am J Transplant 3: 1378-1382, 2003
49. Koch MJ, Bohl DL, Miller BW, Mwintshi K, Lambert M, Brennan DC: Long term (median 5-year) follow-up of preemptive immunosuppression reduction for BK viremia [Abstract]. Am J Transplant 7[Suppl 2]: 151, 2007
50. Saad E, Bresnahan BA, Cohen EP, Hussain SA, Vasudev B, Orentas R, Hariharan S: Reduction in immunosuppression without use of anti-viral therapy in the treatment of BK virus infection after renal transplant [Abstract]. Transplantation 82[Suppl 2]: 938, 2006
51. Arunachalan C, Saundh B, Hale A, Campbell H, Tibble S, Lewington A, Newstead C, Baker R: Incidence of polyoma viruria after renal transplantation in a steroid avoidance regime [Abstract]. Am J Transplant 7[Suppl 2]: 537, 2007
52. Waldman WJ, Knight DA, Blinder L, Shen J, Lurain NS, Miller DM, Sedmak DD, Williams JW, Chong AS: Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Intervirology 42: 412-418, 1999
53. Williams JW, Javaid B, Kadambi PV, Gillen D, Harland R, Thistlewaite JR, Garfinkel M, Foster P, Atwood W, Millis JM, Meehan SM, Josephson MA: Leflunomide for polyomavirus type BK nephropathy. N Engl J Med 352: 1157-1158, 2005
54. Teschner S, Geyer M, Wilpert J, Schwertfeger E, Schenk T, Walz G, Donauer J: Remission of polyomavirus-induced graft nephropathy treated with low-dose leflunomide. Nephrol Dial Transplant 21: 2039-2040, 2006
55. Josephson MA, Gillen D, Javaid B, Kadambi P, Meehan S, Foster P, Harland R, Thistlethwaite RJ, Garfinkel M, Atwood W, Jordan J, Sadhu M, Millis MJ, Williams J: Treatment of renal allograft polyoma BK virus infection with leflunomide. Transplantation 81: 704-710, 2006
56. Kadambi PV, Josephson MA, Williams J, Corey L, Jerome KR, Meehan SM, Limaye AP: Treatment of refractory BK virus-associated nephropathy with cidofovir. Am J Transplant 3: 186-191, 2003
57. Vats A, Shapiro R, Singh Randhawa P, Scantlebury V, Tuzuner A, Saxena M, Moritz ML, Beattie TJ, Gonwa T, Green MD, Ellis D: Quantitative viral load monitoring and cidofovir therapy for the management of BK virus-associated nephropathy in children and adults. Transplantation 75: 105-112, 2003
58. Kuypers DR, Vandooren AK, Lerut E, Evenepoel P, Claes K, Snoeck R, Naesens L, Vanrenterghem Y: Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients. Am J Transplant 5: 1997-2004, 2005
59. Babel N, Hammer MH, Stele L, Bold G, Sefrin A, Volk HD, Reinke P: Anti CD 20-mAb (rituximab) may prevent the progression of BKV-associated nephropathy in renal transplant recipients [Abstract]. Am J Transplant 7[Suppl 2]: 541, 2007
60. Sener A, House AA, Jevnikar AM, Boudville N, McAlister VC, Muirhead N, Rehman F, Luke PP: Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: One-year follow-up of renal allograft recipients. Transplantation 81: 117-120, 2006
61. Wadei HM, Rule AD, Lewin M, Mahale AS, Khamash HA, Schwab TR, Gloor JM, Textor SC, Fidler ME, Lager DJ, Larson TS, Stegall MD, Cosio FG, Griffin MD: Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). Am J Transplant 6: 10251-1032, 2006
62. Medipalli R, Vasudev B, Zhu Y, Saad E, Cohen EP, Orentas R, Jurgens L, Hariharan S: Improved outcomes of BKVN: Impact on BK virus surveillance protocol [Abstract]. Am J Transplant 7[Suppl 2]: 150, 2007
63. Buehrig CK, Lager DJ, Stegall MD, Kreps MA, Kremers WK, Gloor JM, Schwab TR, Velosa JA, Fidler ME, Larson TS, Griffin MD: Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy. Kidney Int 64: 665-673, 2003
64. Khamash HA, Wadei HM, Mahale AS, Larson TS, Stegall MD, Cosio FG, Griffin MD: Polyomavirus-associated nephropathy risk in kidney transplants: The influence of recipient age and donor gender. Kidney Int 71: 1302-1309, 2007
65. Basse G, Mengelle C, Kamar N, Guitard J, Ribes D, Esposito L, Rostaing L: Prospective evaluation of BK virus DNAemia in renal transplant patients and their transplant outcome. Transplant Proc 39: 84-87, 2007
66. Drachenberg C, Hirsch HH, Papadimitriou JC, Mozafari P, Wali R, McKinney JD, Nogueira J, Cangro CB, Mendley S, Klassen DK, Ramos E: Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. Transplant Proc 36: 3028-3031, 2004
67. Vasudev B, Hariharan S, Hussain SA, Zhu YR, Bresnahan BA, Cohen EP: BK virus nephritis: Risk factors, timing, and outcome in renal transplant recipients. Kidney Int 68: 1834-1839, 2005
68. Womer KL, Meier-Kriesche HU, Patton PR, Dibadj K, Bucci CM, Foley D, Fujita S, Croker BP, Howard RJ, Srinivas TR, Kaplan B: Preemptive retransplantation for BK virus nephropathy: Successful outcome despite active viremia. Am J Transplant 6: 209-213, 2006
69. Ramos E, Vincenti F, Lu WX, Shapiro R, Trofe J, Stratta RJ, Jonsson J, Randhawa PS, Drachenberg CB, Papadimitriou JC, Weir MR, Wali RK: Retransplantation in patients with graft loss caused by polyoma virus nephropathy. Transplantation 77: 131-133, 2004
70. Rocha PN, Plumb TJ, Miller SE, Howell DN, Smith SR: Risk factors for BK polyomavirus nephritis in renal allograft recipients. Clin Transplant 18: 456-462, 2004