Use of high throughput qPCR screening to rapidly clone low frequency tumour specific T-cells from peripheral blood for adoptive immunotherapy

Journal of Translational Medicine

Volumn 6, Issue , 2008, Pages

  Kammula, Udai S ^a   Serrano, Oscar K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 100; MELANOMA SPECIFIC ANTIGENS; MELANOMA-SPECIFIC ANTIGENS; TUMOR ANTIGEN; TUMOR PROTEIN;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ARTICLE; ASSAY; CANCER CELL CULTURE; CANCER PATIENT; CD8+ T LYMPHOCYTE; CELL CLONING; CELL EXPANSION; CELL ISOLATION; CELL SPECIFICITY; CONTROLLED STUDY; EFFECTOR CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; BIOASSAY; CELL CLONE; CELL LINE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; METHODOLOGY; NEOPLASM; PATHOLOGY; POLYMERASE CHAIN REACTION;

ANTIGENS, NEOPLASM; BIOLOGICAL ASSAY; CELL LINE; CLONE CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOTHERAPY, ADOPTIVE; NEOPLASM PROTEINS; NEOPLASMS; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 56049084193     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-6-60     Document Type: Article

References (22)

1. Dudley ME Wunderlich JR Robbins PF Yang JC Hwu P Schwartzentruber DJ Topalian SL Sherry R Restifo NP Hubicki AM Robinson MR Raffeld M Duray P Seipp CA Rogers-Freezer L Morton KE Mavroukakis SA White DE Rosenberg SA Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes Science 2002, 298(5594):850-4. 1764179 12242449 10.1126/science.1076514
2. Dudley ME Wunderlich JR Yang JC Sherry RM Topalian SL Restifo NP Royal RE Kammula U White DE Mavroukakis SA Rogers LJ Gracia GJ Jones SA Mangiameli DP Pelletier MM Gea-Banacloche J Robinson MR Berman DM Filie AC Abati A Rosenberg SA Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma J Clin Oncol 2005, 23(10):2346-57. 1475951 15800326 10.1200/JCO.2005.00.240
3. Oelke M Moehrle U Chen JL Behringer D Cerundolo V Lindemann A Mackensen A Generation and purification of CD8+ melan-A-specific cytotoxic T lymphocytes for adoptive transfer in tumor immunotherapy Clin Cancer Res 2000, 6(5):1997-2005. 10815925
4. Mackensen A Meidenbauer N Vogl S Laumer M Berger J Andreesen R Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma J Clin Oncol 2006, 24(31):5060-9. 10.1200/JCO.2006.07.1100 17075125
5. Vignard V Lemercier B Lim A Pandolfino MC Guilloux Y Khammari A Rabu C Echasserieau K Lang F Gougeon ML Dreno B Jotereau F Labarriere N Adoptive transfer of tumor-reactive Melan-A-specific CTL clones in melanoma patients is followed by increased frequencies of additional Melan-A-specific T cells J Immunol 2005, 175(7):4797-805. 16177129
6. Yee C Thompson JA Byrd D Riddell SR Roche P Celis E Greenberg PD Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells Proc Natl Acad Sci USA 2002, 99(25):16168-73. 138583 12427970 10.1073/pnas.242600099
7. Yee C Savage PA Lee PP Davis MM Greenberg PD Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers J Immunol 1999, 162(4):2227-34. 9973498
8. Pittet MJ Valmori D Dunbar PR Speiser DE Liénard D Lejeune F Fleischhauer K Cerundolo V Cerottini JC Romero P High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals J Exp Med 1999, 190(5):705-15. 2195613 10477554 10.1084/jem.190.5.705
9. Powell DJ Jr Dudley ME Hogan KA Wunderlich JR Rosenberg SA Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion J Immunol 2006, 177(9):6527-39. 2174602 17056585
10. Dudley ME Wunderlich J Nishimura MI Yu D Yang JC Topalian SL Schwartzentruber DJ Hwu P Marincola FM Sherry R Leitman SF Rosenberg SA Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma J Immunother (1997) 2001, 24(4):363-73. 10.1097/00002371-200107000-00012
11. Dudley ME Wunderlich JR Yang JC Hwu P Schwartzentruber DJ Topalian SL Sherry RM Marincola FM Leitman SF Seipp CA Rogers-Freezer L Morton KE Nahvi A Mavroukakis SA White DE Rosenberg SA A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma J Immunother (1997) 2002, 25(3):243-51. 10.1097/00002371-200205000-00007
12. Kammula US Lee KH Riker AI Wang E Ohnmacht GA Rosenberg SA Marincola FM Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens J Immunol 1999, 163(12):6867-75. 10586088
13. Kammula US Marincola FM Rosenberg SA Real-time quantitative polymerase chain reaction assessment of immune reactivity in melanoma patients after tumor peptide vaccination J Natl Cancer Inst 2000, 92(16):1336-44. 10.1093/jnci/92.16.1336 10944556
14. Alexander-Miller MA Leggatt GR Berzofsky JA Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy Proc Natl Acad Sci USA 1996, 93(9):4102-7. 39494 8633023 10.1073/pnas.93.9.4102
15. Zeh HJ 3rd Perry-Lalley D Dudley ME Rosenberg SA Yang JC High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy J Immunol 1999, 162(2):989-94. 9916724
16. Gattinoni L Klebanoff CA Palmer DC Wrzesinski C Kerstann K Yu Z Finkelstein SE Theoret MR Rosenberg SA Restifo NP Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells J Clin Invest 2005, 115(6):1616-26. 1137001 15931392 10.1172/JCI24480
17. Zhou J Shen X Huang J Hodes RJ Rosenberg SA Robbins PF Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy J Immunol 2005, 175(10):7046-52. 1351312 16272366
18. Huang J Kerstann KW Ahmadzadeh M Li YF El-Gamil M Rosenberg SA Robbins PF Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy J Immunol 2006, 176(12):7726-35. 1532931 16751420
19. Yee C Greenberg P Modulating T-cell immunity to tumours: New strategies for monitoring T-cell responses Nat Rev Cancer 2002, 2(6):409-19. 10.1038/nrc820 12189383
20. Dunbar PR Chen JL Chao D Rust N Teisserenc H Ogg GS Romero P Weynants P Cerundolo V Cutting edge: Rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma J Immunol 1999, 162(12):6959-62. 10358133
21. Salgaller ML Afshar A Marincola FM Rivoltini L Kawakami Y Rosenberg SA Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides Cancer Res 1995, 55(21):4972-9. 7585538
22. Parkhurst MR Salgaller ML Southwood S Robbins PF Sette A Rosenberg SA Kawakami Y Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues J Immunol 1996, 157(6):2539-48. 8805655