-
1
-
-
33846693507
-
Early Rheumatoid Arthritis Study (ERAS) Group: Mortality in rheumatoid arthritis
-
Young A, Koduri G, Batley M, et al.: Early Rheumatoid Arthritis Study (ERAS) Group: Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology (Oxford) 2007, 46: 350-357.
-
(2007)
Rheumatology (Oxford)
, vol.46
, pp. 350-357
-
-
Young, A.1
Koduri, G.2
Batley, M.3
-
2
-
-
0025648429
-
Remodeling the pyramid or remodeling the paradigms concerning rheumatoid arthritis-lessons from Hodgkin's disease and coronary artery disease
-
Pincus T, Callahan LF: Remodeling the pyramid or remodeling the paradigms concerning rheumatoid arthritis-lessons from Hodgkin's disease and coronary artery disease. J Rheumatol 1990, 17: 1582-1585.
-
(1990)
J Rheumatol
, vol.17
, pp. 1582-1585
-
-
Pincus, T.1
Callahan, L.F.2
-
3
-
-
0036169930
-
Guidelines for the management of rheumatoid arthritis: 2002 Update
-
American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines:
-
American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines: Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum 2002, 46: 328-346.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 328-346
-
-
-
4
-
-
0024360388
-
The biology of interleukin-6
-
Kishimoto T: The biology of interleukin-6. Blood 1989, 74: 1-10.
-
(1989)
Blood
, vol.74
, pp. 1-10
-
-
Kishimoto, T.1
-
5
-
-
18644385612
-
IL-6 transsignaling: The in vivo consequences
-
Jones S, Richards PJ, Scheller J, Rose-John S: IL-6 transsignaling: The in vivo consequences. J Interferon Cytokine Res 2005, 25: 241-253.
-
(2005)
J Interferon Cytokine Res
, vol.25
, pp. 241-253
-
-
Jones, S.1
Richards, P.J.2
Scheller, J.3
Rose-John, S.4
-
6
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington L, Hatton RD, Mangan PR, et al.: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunol 2005, 6: 1123-1132.
-
(2005)
Nature Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.1
Hatton, R.D.2
Mangan, P.R.3
-
7
-
-
33846456970
-
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
-
Hirota K, Hashimoto M, Yoshitomi H, et al.: T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 2007, 204: 41-47.
-
(2007)
J Exp Med
, vol.204
, pp. 41-47
-
-
Hirota, K.1
Hashimoto, M.2
Yoshitomi, H.3
-
8
-
-
33646577466
-
Reciprocal development pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, et al.: Reciprocal development pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441: 235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
9
-
-
0027518860
-
Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
-
Madhok R, Crilly A, Watson J, Capell HA: Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity. Ann Rheum Dis 1993, 52: 232-234.
-
(1993)
Ann Rheum Dis
, vol.52
, pp. 232-234
-
-
Madhok, R.1
Crilly, A.2
Watson, J.3
Capell, H.A.4
-
10
-
-
0344534939
-
Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies
-
Uson J, Balsa A, Pascual-Salcedo D, et al.: Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies. J Rheumatol 1997, 24: 2069-2075.
-
(1997)
J Rheumatol
, vol.24
, pp. 2069-2075
-
-
Uson, J.1
Balsa, A.2
Pascual-Salcedo, D.3
-
11
-
-
13344250490
-
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
-
Kotake S, Sato K, Kim KJ, et al.: Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 1996, 11: 88-95.
-
(1996)
J Bone Miner Res
, vol.11
, pp. 88-95
-
-
Kotake, S.1
Sato, K.2
Kim, K.J.3
-
12
-
-
0026527781
-
Interleukin 6 levels in synovial fluids of patients with different arthritides: Correlation with local IgM rheumatoid factor and systemic acute phase protein production
-
Brozik M, Rosztoczy I, Meretey K, et al.: Interleukin 6 levels in synovial fluids of patients with different arthritides: Correlation with local IgM rheumatoid factor and systemic acute phase protein production. J Rheumatol 1992, 19: 63-68.
-
(1992)
J Rheumatol
, vol.19
, pp. 63-68
-
-
Brozik, M.1
Rosztoczy, I.2
Meretey, K.3
-
13
-
-
0030891228
-
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
-
Romano M, Sironi M, Toniatti C, et al.: Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997, 6: 315-325.
-
(1997)
Immunity
, vol.6
, pp. 315-325
-
-
Romano, M.1
Sironi, M.2
Toniatti, C.3
-
14
-
-
27744470765
-
A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium
-
Lally F, Smith E, Filer A, et al.: A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum 2005, 52: 3460-3469.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 3460-3469
-
-
Lally, F.1
Smith, E.2
Filer, A.3
-
15
-
-
0038798085
-
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
-
Nakahara H, Song J, Sugimoto M, et al.: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum 2003, 48: 1521-1529.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1521-1529
-
-
Nakahara, H.1
Song, J.2
Sugimoto, M.3
-
16
-
-
3242781731
-
Clinical implications of the osteoprotegrin/RANKL/RANK system for bone and vascular diseases
-
Hofbauer LC, Schoppet M: Clinical implications of the osteoprotegrin/ RANKL/RANK system for bone and vascular diseases. JAMA 2004, 292: 490-495.
-
(2004)
JAMA
, vol.292
, pp. 490-495
-
-
Hofbauer, L.C.1
Schoppet, M.2
-
17
-
-
0031895576
-
IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures
-
Devlin RD, Reddy SV, Savino R, et al.: IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures. J Bone Miner Res 1998, 13: 393-399.
-
(1998)
J Bone Miner Res
, vol.13
, pp. 393-399
-
-
Devlin, R.D.1
Reddy, S.V.2
Savino, R.3
-
18
-
-
1242339610
-
IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro
-
Gorny G, Shaw A, Oursler MJ: IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro. Exp Cell Res 2004, 294: 149-158.
-
(2004)
Exp Cell Res
, vol.294
, pp. 149-158
-
-
Gorny, G.1
Shaw, A.2
Oursler, M.J.3
-
19
-
-
0024592982
-
Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis
-
Guerne PA, Zuraw BL, Vaughan JH, et al.: Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 1989, 83: 585-592.
-
(1989)
J Clin Invest
, vol.83
, pp. 585-592
-
-
Guerne, P.A.1
Zuraw, B.L.2
Vaughan, J.H.3
-
20
-
-
0026537579
-
Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis
-
Dasgupta B, Corkill M, Kirkham B, et al.: Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol 1992, 19: 22-25.
-
(1992)
J Rheumatol
, vol.19
, pp. 22-25
-
-
Dasgupta, B.1
Corkill, M.2
Kirkham, B.3
-
21
-
-
0033545342
-
Acute-phase proteins and other systemic responses to inflammation
-
Gabay C, Kushner I: Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340: 448-454.
-
(1999)
N Engl J Med
, vol.340
, pp. 448-454
-
-
Gabay, C.1
Kushner, I.2
-
22
-
-
35948976581
-
Association of anemia and physical disability among patients with rheumatoid arthritis
-
Han C, Rahman MU, Doyle MK, et al.: Association of anemia and physical disability among patients with rheumatoid arthritis. J Rheumatol 2007, 34: 2177-2182.
-
(2007)
J Rheumatol
, vol.34
, pp. 2177-2182
-
-
Han, C.1
Rahman, M.U.2
Doyle, M.K.3
-
23
-
-
9044236905
-
IL-6-induced anaemia in rats: Possible pathogenetic implications for anemia observed in chronic inflammations
-
Jongen-Lavrencic M, Peeters HR, Rozemuller H, et al.: IL-6-induced anaemia in rats: Possible pathogenetic implications for anemia observed in chronic inflammations. Clin Exp Immunol 1996, 103: 328-334.
-
(1996)
Clin Exp Immunol
, vol.103
, pp. 328-334
-
-
Jongen-Lavrencic, M.1
Peeters, H.R.2
Rozemuller, H.3
-
24
-
-
0032805582
-
Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis
-
Voulgari PV, Kolios G, Papadopoulos GK, et al.: Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis. Clin Immunol 1999, 92: 153-160.
-
(1999)
Clin Immunol
, vol.92
, pp. 153-160
-
-
Voulgari, P.V.1
Kolios, G.2
Papadopoulos, G.K.3
-
25
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, Tuttle MS, Powelson J, et al.: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306: 2090-2093.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
-
26
-
-
33748092926
-
Interleukin-6 and rheumatic diseases
-
Lipsky PE: Interleukin-6 and rheumatic diseases. Arthritis Res Ther 2006, 8(Suppl 2): S4.
-
(2006)
Arthritis Res Ther
, vol.8
, Issue.SUPPL. 2
-
-
Lipsky, P.E.1
-
27
-
-
33750953842
-
Impaired skeletal development in interleukin-6-transgenic mice: A model for the impact of chronic inflammation on the growing skeletal system
-
De Benedetti F, Rucci N, Del Fattore A, et al.: Impaired skeletal development in interleukin-6-transgenic mice: A model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum 2006, 54: 3551-3563.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 3551-3563
-
-
De Benedetti, F.1
Rucci, N.2
Del Fattore, A.3
-
28
-
-
0036899812
-
Therapeutic benefit of blocking interleukin-6 activity with an antiinterleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
-
Choy EH, Isenberg DA, Garrood T, et al.: Therapeutic benefit of blocking interleukin-6 activity with an antiinterleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 2002, 46: 3143-3150.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 3143-3150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
-
29
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial
-
Nishimoto N, Yoshizaki K, Miyasaka N, et al.: Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial. Arthritis Rheum 2004, 50: 1761-1769.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
Yoshizaki, K.2
Miyasaka, N.3
-
30
-
-
33749363027
-
CHARISMA Study Group: Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
-
Maini RN, Taylor PC, Szechinski J, et al.: CHARISMA Study Group: Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 2006, 54: 2817-2829.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2817-2829
-
-
Maini, R.N.1
Taylor, P.C.2
Szechinski, J.3
-
31
-
-
34447300492
-
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
-
Nishimoto N, Hashimoto J, Miyasaka N, et al.: Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis 2007, 66: 1162-1167.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 1162-1167
-
-
Nishimoto, N.1
Hashimoto, J.2
Miyasaka, N.3
-
32
-
-
40749114497
-
OPTION Investigators: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
-
Smolen JS, Beaulieu A, Rubbert-Roth A, et al.: OPTION Investigators: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 2008, 371: 987-997.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
-
33
-
-
59249098125
-
Targeting the IL-6 receptor with the monoclonal antibody tocilizumab significantly improves quality of life with rheumatoid arthritis [presentation 292]
-
Presented at the Boston, MA; November 6-11
-
Smolen J, Rovensky J, Ramos-Remus C, et al.: Targeting the IL-6 receptor with the monoclonal antibody tocilizumab significantly improves quality of life with rheumatoid arthritis [presentation 292]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
-
(2008)
American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
-
-
Smolen, J.1
Rovensky, J.2
Ramos-Remus, C.3
-
34
-
-
59249108916
-
Relationship between serum concentrations of the interleukin-6 receptor inhibitor tocilizumab and C-reactive protein reduction in RA patients: 6 months' data from a phase 3 study [presentation 259]
-
Presented at the Boston, MA; November 6-11
-
Frey N, Grange S, Woodworth T, et al.: Relationship between serum concentrations of the interleukin-6 receptor inhibitor tocilizumab and C-reactive protein reduction in RA patients: 6 months' data from a phase 3 study [presentation 259]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
-
(2008)
American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
-
-
Frey, N.1
Grange, S.2
Woodworth, T.3
-
35
-
-
59249083279
-
IL-6 receptor inhibition with tocilizumab reduces disease activity in patients with rheumatoid arthritis with inadequate response to a range of DMARDs: The TOWARD study [presentation L15]
-
Presented at the Boston, MA; November 6-11
-
Genovese M, McKay J, Nasonov E, et al.: IL-6 receptor inhibition with tocilizumab reduces disease activity in patients with rheumatoid arthritis with inadequate response to a range of DMARDs: The TOWARD study [presentation L15]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
-
(2008)
American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
-
-
Genovese, M.1
McKay, J.2
Nasonov, E.3
-
36
-
-
59249091348
-
Targeted inhibition of IL-6 signaling with tocilizumab improves quality of life and function in patients with rheumatoid arthritis with inadequate response to a range of DMARDs [presentation L6]
-
Presented at the Boston, MA; November 6-11
-
Gomez-Reino JJ, Fairfax MJ, Pavelka K, et al.: Targeted inhibition of IL-6 signaling with tocilizumab improves quality of life and function in patients with rheumatoid arthritis with inadequate response to a range of DMARDs [presentation L6]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
-
(2008)
American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
-
-
Gomez-Reino, J.J.1
Fairfax, M.J.2
Pavelka, K.3
|