메뉴 건너뛰기




Volumn 10, Issue 5, 2008, Pages 413-417

Inhibiting interleukin-6 in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ATLIZUMAB; INTERLEUKIN 6; METHOTREXATE; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; ANTIRHEUMATIC AGENT; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY;

EID: 55949136066     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-008-0066-x     Document Type: Review
Times cited : (11)

References (36)
  • 1
    • 33846693507 scopus 로고    scopus 로고
    • Early Rheumatoid Arthritis Study (ERAS) Group: Mortality in rheumatoid arthritis
    • Young A, Koduri G, Batley M, et al.: Early Rheumatoid Arthritis Study (ERAS) Group: Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology (Oxford) 2007, 46: 350-357.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 350-357
    • Young, A.1    Koduri, G.2    Batley, M.3
  • 2
    • 0025648429 scopus 로고
    • Remodeling the pyramid or remodeling the paradigms concerning rheumatoid arthritis-lessons from Hodgkin's disease and coronary artery disease
    • Pincus T, Callahan LF: Remodeling the pyramid or remodeling the paradigms concerning rheumatoid arthritis-lessons from Hodgkin's disease and coronary artery disease. J Rheumatol 1990, 17: 1582-1585.
    • (1990) J Rheumatol , vol.17 , pp. 1582-1585
    • Pincus, T.1    Callahan, L.F.2
  • 3
    • 0036169930 scopus 로고    scopus 로고
    • Guidelines for the management of rheumatoid arthritis: 2002 Update
    • American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines:
    • American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines: Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum 2002, 46: 328-346.
    • (2002) Arthritis Rheum , vol.46 , pp. 328-346
  • 4
    • 0024360388 scopus 로고
    • The biology of interleukin-6
    • Kishimoto T: The biology of interleukin-6. Blood 1989, 74: 1-10.
    • (1989) Blood , vol.74 , pp. 1-10
    • Kishimoto, T.1
  • 6
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L, Hatton RD, Mangan PR, et al.: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunol 2005, 6: 1123-1132.
    • (2005) Nature Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.1    Hatton, R.D.2    Mangan, P.R.3
  • 7
    • 33846456970 scopus 로고    scopus 로고
    • T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    • Hirota K, Hashimoto M, Yoshitomi H, et al.: T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 2007, 204: 41-47.
    • (2007) J Exp Med , vol.204 , pp. 41-47
    • Hirota, K.1    Hashimoto, M.2    Yoshitomi, H.3
  • 8
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal development pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al.: Reciprocal development pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 9
    • 0027518860 scopus 로고
    • Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
    • Madhok R, Crilly A, Watson J, Capell HA: Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity. Ann Rheum Dis 1993, 52: 232-234.
    • (1993) Ann Rheum Dis , vol.52 , pp. 232-234
    • Madhok, R.1    Crilly, A.2    Watson, J.3    Capell, H.A.4
  • 10
    • 0344534939 scopus 로고    scopus 로고
    • Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies
    • Uson J, Balsa A, Pascual-Salcedo D, et al.: Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies. J Rheumatol 1997, 24: 2069-2075.
    • (1997) J Rheumatol , vol.24 , pp. 2069-2075
    • Uson, J.1    Balsa, A.2    Pascual-Salcedo, D.3
  • 11
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S, Sato K, Kim KJ, et al.: Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 1996, 11: 88-95.
    • (1996) J Bone Miner Res , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3
  • 12
    • 0026527781 scopus 로고
    • Interleukin 6 levels in synovial fluids of patients with different arthritides: Correlation with local IgM rheumatoid factor and systemic acute phase protein production
    • Brozik M, Rosztoczy I, Meretey K, et al.: Interleukin 6 levels in synovial fluids of patients with different arthritides: Correlation with local IgM rheumatoid factor and systemic acute phase protein production. J Rheumatol 1992, 19: 63-68.
    • (1992) J Rheumatol , vol.19 , pp. 63-68
    • Brozik, M.1    Rosztoczy, I.2    Meretey, K.3
  • 13
    • 0030891228 scopus 로고    scopus 로고
    • Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    • Romano M, Sironi M, Toniatti C, et al.: Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997, 6: 315-325.
    • (1997) Immunity , vol.6 , pp. 315-325
    • Romano, M.1    Sironi, M.2    Toniatti, C.3
  • 14
    • 27744470765 scopus 로고    scopus 로고
    • A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium
    • Lally F, Smith E, Filer A, et al.: A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum 2005, 52: 3460-3469.
    • (2005) Arthritis Rheum , vol.52 , pp. 3460-3469
    • Lally, F.1    Smith, E.2    Filer, A.3
  • 15
    • 0038798085 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
    • Nakahara H, Song J, Sugimoto M, et al.: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum 2003, 48: 1521-1529.
    • (2003) Arthritis Rheum , vol.48 , pp. 1521-1529
    • Nakahara, H.1    Song, J.2    Sugimoto, M.3
  • 16
    • 3242781731 scopus 로고    scopus 로고
    • Clinical implications of the osteoprotegrin/RANKL/RANK system for bone and vascular diseases
    • Hofbauer LC, Schoppet M: Clinical implications of the osteoprotegrin/ RANKL/RANK system for bone and vascular diseases. JAMA 2004, 292: 490-495.
    • (2004) JAMA , vol.292 , pp. 490-495
    • Hofbauer, L.C.1    Schoppet, M.2
  • 17
    • 0031895576 scopus 로고    scopus 로고
    • IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures
    • Devlin RD, Reddy SV, Savino R, et al.: IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures. J Bone Miner Res 1998, 13: 393-399.
    • (1998) J Bone Miner Res , vol.13 , pp. 393-399
    • Devlin, R.D.1    Reddy, S.V.2    Savino, R.3
  • 18
    • 1242339610 scopus 로고    scopus 로고
    • IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro
    • Gorny G, Shaw A, Oursler MJ: IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro. Exp Cell Res 2004, 294: 149-158.
    • (2004) Exp Cell Res , vol.294 , pp. 149-158
    • Gorny, G.1    Shaw, A.2    Oursler, M.J.3
  • 19
    • 0024592982 scopus 로고
    • Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis
    • Guerne PA, Zuraw BL, Vaughan JH, et al.: Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 1989, 83: 585-592.
    • (1989) J Clin Invest , vol.83 , pp. 585-592
    • Guerne, P.A.1    Zuraw, B.L.2    Vaughan, J.H.3
  • 20
    • 0026537579 scopus 로고
    • Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis
    • Dasgupta B, Corkill M, Kirkham B, et al.: Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol 1992, 19: 22-25.
    • (1992) J Rheumatol , vol.19 , pp. 22-25
    • Dasgupta, B.1    Corkill, M.2    Kirkham, B.3
  • 21
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to inflammation
    • Gabay C, Kushner I: Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340: 448-454.
    • (1999) N Engl J Med , vol.340 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 22
    • 35948976581 scopus 로고    scopus 로고
    • Association of anemia and physical disability among patients with rheumatoid arthritis
    • Han C, Rahman MU, Doyle MK, et al.: Association of anemia and physical disability among patients with rheumatoid arthritis. J Rheumatol 2007, 34: 2177-2182.
    • (2007) J Rheumatol , vol.34 , pp. 2177-2182
    • Han, C.1    Rahman, M.U.2    Doyle, M.K.3
  • 23
    • 9044236905 scopus 로고    scopus 로고
    • IL-6-induced anaemia in rats: Possible pathogenetic implications for anemia observed in chronic inflammations
    • Jongen-Lavrencic M, Peeters HR, Rozemuller H, et al.: IL-6-induced anaemia in rats: Possible pathogenetic implications for anemia observed in chronic inflammations. Clin Exp Immunol 1996, 103: 328-334.
    • (1996) Clin Exp Immunol , vol.103 , pp. 328-334
    • Jongen-Lavrencic, M.1    Peeters, H.R.2    Rozemuller, H.3
  • 24
    • 0032805582 scopus 로고    scopus 로고
    • Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis
    • Voulgari PV, Kolios G, Papadopoulos GK, et al.: Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis. Clin Immunol 1999, 92: 153-160.
    • (1999) Clin Immunol , vol.92 , pp. 153-160
    • Voulgari, P.V.1    Kolios, G.2    Papadopoulos, G.K.3
  • 25
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al.: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306: 2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 26
    • 33748092926 scopus 로고    scopus 로고
    • Interleukin-6 and rheumatic diseases
    • Lipsky PE: Interleukin-6 and rheumatic diseases. Arthritis Res Ther 2006, 8(Suppl 2): S4.
    • (2006) Arthritis Res Ther , vol.8 , Issue.SUPPL. 2
    • Lipsky, P.E.1
  • 27
    • 33750953842 scopus 로고    scopus 로고
    • Impaired skeletal development in interleukin-6-transgenic mice: A model for the impact of chronic inflammation on the growing skeletal system
    • De Benedetti F, Rucci N, Del Fattore A, et al.: Impaired skeletal development in interleukin-6-transgenic mice: A model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum 2006, 54: 3551-3563.
    • (2006) Arthritis Rheum , vol.54 , pp. 3551-3563
    • De Benedetti, F.1    Rucci, N.2    Del Fattore, A.3
  • 28
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an antiinterleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
    • Choy EH, Isenberg DA, Garrood T, et al.: Therapeutic benefit of blocking interleukin-6 activity with an antiinterleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 2002, 46: 3143-3150.
    • (2002) Arthritis Rheum , vol.46 , pp. 3143-3150
    • Choy, E.H.1    Isenberg, D.A.2    Garrood, T.3
  • 29
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial
    • Nishimoto N, Yoshizaki K, Miyasaka N, et al.: Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial. Arthritis Rheum 2004, 50: 1761-1769.
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3
  • 30
    • 33749363027 scopus 로고    scopus 로고
    • CHARISMA Study Group: Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini RN, Taylor PC, Szechinski J, et al.: CHARISMA Study Group: Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 2006, 54: 2817-2829.
    • (2006) Arthritis Rheum , vol.54 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3
  • 31
    • 34447300492 scopus 로고    scopus 로고
    • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
    • Nishimoto N, Hashimoto J, Miyasaka N, et al.: Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis 2007, 66: 1162-1167.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3
  • 32
    • 40749114497 scopus 로고    scopus 로고
    • OPTION Investigators: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A, et al.: OPTION Investigators: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 2008, 371: 987-997.
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 33
    • 59249098125 scopus 로고    scopus 로고
    • Targeting the IL-6 receptor with the monoclonal antibody tocilizumab significantly improves quality of life with rheumatoid arthritis [presentation 292]
    • Presented at the Boston, MA; November 6-11
    • Smolen J, Rovensky J, Ramos-Remus C, et al.: Targeting the IL-6 receptor with the monoclonal antibody tocilizumab significantly improves quality of life with rheumatoid arthritis [presentation 292]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
    • (2008) American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
    • Smolen, J.1    Rovensky, J.2    Ramos-Remus, C.3
  • 34
    • 59249108916 scopus 로고    scopus 로고
    • Relationship between serum concentrations of the interleukin-6 receptor inhibitor tocilizumab and C-reactive protein reduction in RA patients: 6 months' data from a phase 3 study [presentation 259]
    • Presented at the Boston, MA; November 6-11
    • Frey N, Grange S, Woodworth T, et al.: Relationship between serum concentrations of the interleukin-6 receptor inhibitor tocilizumab and C-reactive protein reduction in RA patients: 6 months' data from a phase 3 study [presentation 259]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
    • (2008) American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
    • Frey, N.1    Grange, S.2    Woodworth, T.3
  • 35
    • 59249083279 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab reduces disease activity in patients with rheumatoid arthritis with inadequate response to a range of DMARDs: The TOWARD study [presentation L15]
    • Presented at the Boston, MA; November 6-11
    • Genovese M, McKay J, Nasonov E, et al.: IL-6 receptor inhibition with tocilizumab reduces disease activity in patients with rheumatoid arthritis with inadequate response to a range of DMARDs: The TOWARD study [presentation L15]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
    • (2008) American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
    • Genovese, M.1    McKay, J.2    Nasonov, E.3
  • 36
    • 59249091348 scopus 로고    scopus 로고
    • Targeted inhibition of IL-6 signaling with tocilizumab improves quality of life and function in patients with rheumatoid arthritis with inadequate response to a range of DMARDs [presentation L6]
    • Presented at the Boston, MA; November 6-11
    • Gomez-Reino JJ, Fairfax MJ, Pavelka K, et al.: Targeted inhibition of IL-6 signaling with tocilizumab improves quality of life and function in patients with rheumatoid arthritis with inadequate response to a range of DMARDs [presentation L6]. Presented at the American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting. Boston, MA; November 6-11, 2008.
    • (2008) American College of Rheumatology/Association of Rheumatology Professionals 2007 Scientific Meeting
    • Gomez-Reino, J.J.1    Fairfax, M.J.2    Pavelka, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.