Plasma malondialdehyde levels and opiate withdrawal signs observed in rats treated with morphine plus naloxone: Effects of α-lipoic acid administration

Fundamental and Clinical Pharmacology

Volumn 22, Issue 4, 2008, Pages 439-445

  Pinelli, Arnaldo ^a   Cighetti, Giuliana ^a   Trivulzio, Silvio ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

lipoic acid; Arachidonate metabolites; Fecal excretion; Jumping; Latency times or pain threshold levels; Malondialdehyde; Morphine and morphine withdrawal; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; MALONALDEHYDE; MORPHINE; NALOXONE; OPIATE; PEROXIDE; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; NARCOTIC AGENT; NARCOTIC ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG WITHDRAWAL; FECES; JUMPING; LATENT PERIOD; MALE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; SYMPTOMATOLOGY; WITHDRAWAL SYNDROME; ANIMAL; ANIMAL BEHAVIOR; BLOOD; DEFECATION; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; MASS FRAGMENTOGRAPHY; OXIDATIVE STRESS; PATHOPHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; DEFECATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MALONDIALDEHYDE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; OXIDATIVE STRESS; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME; THIOCTIC ACID;

EID: 55949133117     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2008.00612.x     Document Type: Article

References (41)

1. Di Francesco P., Tavazzi B., Gaziano R. et al. Differential effects of acute morphine administrations on polymorphonuclear cell metabolism in various mouse strains. Life Sci. (1998) 63 2167-2174.
2. Singhal P.C., Pamarthi M., Shah R., Chandra D., Gibbons N. Morphine stimulates superoxide formation by glomerular mesangial cells. Inflammation (1994) 18 293-299.
3. William S., Sekar N., Subramanian S., Govindasamy S. Toxic effect of morphine and the antagonistic role of naloxone on isolated rat hepatocytes. Biochem. Int. (1991) 23 1071-1077.
4. Goudas L.C., Carr D.B., Maszczynska I. et al. Differential effect of central versus parenteral administration of morphine sulfate on regional concentrations of reduced glutathione in rat brain. Pharmacology (1997) 54 92-97.
5. Goudas L.C., Langlade A., Serrie A. et al. Acute decreases in cerebrospinal fluid glutathione levels after intracerebroventric-ular morphine for cancer pain. Anesth. Analg. (1999) 89 1209-1215.
6. Xu B., Wang Z., Li G. et al. Heroin-administered mice involved in oxidative stress and exogenous antioxidant-alleviated withdrawal syndrome. Basic Clin. Pharmacol. Toxicol. (2006) 99 153-161.
7. Del Rio D., Stewart A.J., Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr. Metab. Cardiovasc. Dis. (2005) 15 316-328.
8. Cighetti G., Debiasi S., Paroni R., Allevi P. Free and total malondialdehyde assessment in biological matrices by gas chromatography-mass spectrometry: what is needed for an accurate detection. Anal. Biochem. (1999) 266 222-229.
9. Biewenga G.P., Haenen G.R., Bast A. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. (1997) 29 315-331.
10. Pinelli A., Trivulzio S. Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine. J. Pharmacol. Toxicol. Methods (1997) 38 117-131.
11. Pinelli A., Trivulzio S., Tomasoni L. Effects of administration of phentonium bromide on opioid withdrawal syndrome in rats. J. Pharm. Pharmacol. (1997) 49 1222-1228.
12. Pinelli A., Trivulzio S., Vignati S. Effects exerted by otilonium bromide administration on precipitated opioid withdrawal syndrome in rats. Toxicology (1997) 122 23-37.
13. Harris L.S., Dewey W.L., Howes J.F., Kennedy J.S., Pars H. Narcotic antagonist analgesics: interactions with cholinergic systems. J. Pharmacol. Exp. Ther. (1969) 169 17-22.
14. Armitage P. Statistica medica, 10th edn Feltrinelli, Milano, 1991.
15. Afanas'ev I.B., Dorozhko A.I., Polozova N.I. et al. Is superoxide an initiator of microsomal lipid peroxidation? Arch. Biochem. Biophys. (1993) 302 200-205.
16. Draper H.H., Csallany A.S., Hadley M. Urinary aldehydes as indicators of lipid peroxidation in vivo. Free Radic. Biol. Med. (2000) 29 1071-1077.
17. Dhanakoti S.N., Draper H.H. Response of urinary malondialdehyde to factors that stimulate lipid peroxidation in vivo. Lipids (1987) 22 643-646.
18. Moser J., Bagchi D., Akubue P.I., Stohs S.J. Excretion of malondialdehyde, formaldehyde, acetaldehyde and acetone in the urine of rats following acute and chronic administration of ethanol. Alcohol Alcohol. (1993) 28 287-295.
19. Baumann J., Wurm G. Studies on the possible involvement of singlet oxygen and superoxide anion radicals in the cyclo-oxygenase reaction. Prostaglandins Leukot. Med. (1984) 14 139-152.
20. Dotan Y., Lichtenberg D., Pinchuk I. Lipid peroxidation cannot be used as a universal criterion of oxidative stress. Prog. Lipid Res. (2004)43 200-227.
21. Trang T., Sutak M., Quirion R., Jhamandas K. The role of spinal neuropeptides and prostaglandins in opioid physical dependence. Br. J. Pharmacol. (2002) 136 37-48.
22. Dunbar S.A., Karamov I.G., Buerkle H. The effect of spinal ibuprofen on opioid withdrawal in the rat. Anesth. Analg. (2000) 91 417-422.
23. Trang T., McNaull B., Quirion R., Jhamandas K. Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance. Eur. J. Pharmacol. (2004) 491 21-30.
24. Redmond D.E. Jr, Krystal J.H. Multiple mechanisms of withdrawal from opioid drugs. Annu. Rev. Neurosci. (1984) 7 443-478.
25. Beubler E., Bukhave K., Rask-Madsen J. Colonic secretion mediated by prostaglandin E2, and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat. Gastroenterology (1984) 87 1042-1048.
26. Coupar I.M., Hardcastle J., Hardcastle P.T. The response of the intestinal mucosa to prostaglandin E2, during withdrawal from morphine. J. Pharm. Pharmacol. (1988) 40 262-266.
27. Capasso A. Further studies on the involvement of the arachi-donic acid cascade in the acute dependence produced by mu, kappa and delta opioid agonists in isolated tissues. Neurophar-macology (1999) 38 871-877.
28. Capasso A., Sorrentino L. Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. Eur. J. Pharmacol. (1997) 330 199-204.
29. Lal H. Narcotic dependence, narcotic action and dopamine receptors. Life Sci. (1975) 17 483-495.
30. Blasig J., Gramsch C., Laschka E., Herz A. The role of dopamine in withdrawal jumping in morphine dependent rats. Arznei-mittelforschung (1976) 26 1104-1106.
31. Enrico P., Esposito G., Mura M.A. et al. Effects of allopurinol on striatal dopamine, ascorbate and uric acid during an acute morphine challenge: ex vivo and in vivo studies. Pharmacol. Res. (1997) 35 577-585.
32. Jameel N.M., Shekhar M.A., Vishwanath B.S. Alpha-lipoic acid: an inhibitor of secretory phospholipase A2, with anti-inflammatory activity. Life Sci. (2006) 80 146-153.
33. Smyth E.M., Burke A., Fitzgerald G.A. Lipid-derived autacoids: eicosanoids and platelet-activating factor, in: Brunton L.L. (Ed.), Lazo J.S., Parker K.L. (Ass. Eds), Goodman and Gilman's the pharmacological basis of therapeutics, 11th edn, McGraw-Hill Companies, New York, USA, 2006, pp. 653-670.
34. Ha H., Lee J.H., Kim H.N. et al. Alpha-lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J. Immunol. (2006) 176 111-117.
35. Lapenna D., Ciofani G., Pierdomenico S.D., Giamberardino M.A., Cuccurullo F. Dihydrolipoic acid inhibits 15-lipoxygen-ase-dependent lipid peroxidation. Free Radic. Biol. Med. (2003) 35 1203-1209.
36. Bilska A., Dubiel M., Sokolowska-Jezewicz M., Lorenc-Koci E., Wlodek L. Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience (2007) 146 1758-1771.
37. Johnston P.A., Chahl L.A. Chronic treatment with ascorbic acid inhibits the morphine withdrawal response in guinea-pigs. Neurosci. Lett. (1992) 135 23-27.
38. Khanna N.C., Sharma S.K. Megadoses of vitamin C prevent the development of tolerance and physical dependence on morphine in mice. Life Sci. (1983) 33(Suppl 1) 401-404.
39. Evangelou A., Kalfakakou V., Georgakas P. et al. Ascorbic acid (vitamin C) effects on withdrawal syndrome of heroin abusers. In Vivo (2000) 14 363-366.
40. Panchenko L.F., Pirozhkov S.V., Nadezhdin A.V., Baronets Vlu., Usmanova N.N. Lipid peroxidation, peroxyl radical-scavenging system of plasma and liver and heart pathology in adolescence heroin users. Vopr. Med. Khim. (1999) 45 501-506.
41. Diaz-Flores Estevez J.F., Diaz-Flores Estevez F., Hernandez Calzadilla C., Rodriguez Rodriguez E.M., Diaz Romero C., Serra-Majem L. Application of linear discriminant analysis to the biochemical and haematological differentiation of opiate addicts from healthy subjects: a case-control study. Eur. J. Clin. Nutr. (2004) 58 449-455.