Hepatic glucose production and insulin resistance

Wiener Medizinische Wochenschrift

Volumn 158, Issue 19-20, 2008, Pages 558-561

  Roden, Michael ^a,b,c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Karl Landsteiner Institute for Endocrinology and Metabolism   (Austria)

^c HANUSCH HOSPITAL   (Austria)

Author keywords

Catecholamines; Diabetes mellitus; Glycogenolysis; Lipotoxicity; Steatosis

Indexed keywords

ADRENALIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LACTIC ACID; LEPTIN; OLEIC ACID; PALMITIC ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SOMATOMEDIN C; TRIACYLGLYCEROL; TROGLITAZONE;

ANIMAL TISSUE; CONFERENCE PAPER; DOWN REGULATION; ENZYME SYNTHESIS; GLUCONEOGENESIS; INSULIN RESISTANCE; LIVER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRITIONAL STATUS; OBESITY; PATHOGENESIS; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ADIPOKINES; ANIMALS; BLOOD GLUCOSE; EPINEPHRINE; FATTY ACIDS, NONESTERIFIED; GLUCAGON; GLUCONEOGENESIS; GLYCOGENOLYSIS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; LIVER; MALE; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 55949130046     PISSN: 00435341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10354-008-0595-y     Document Type: Conference Paper

References (16)

1. M Roden E Bernroider 2003 Hepatic glucose metabolism - its role in health and disease Best Pract Res Cl 17 365 383
2. Krssak M, Roden M. Assessment of metabolic fluxes by in vivo MR spectroscopy. In: Roden M (ed) Clinical diabetes research: methods and techniques. Wiley's, London, Great Britain, chapter 11, pp 193-223, 2007
3. M Roden G Perseghin K Falk Petersen J-H Hwang GW Cline K Gerow DL Rothman GI Shulman 1996 The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans J Clin Invest 97 642 648
4. P Staehr O Hother-Nielsen H Beck-Nielsen M Roden JJ Holst PK Jones V Chandramouli BR Landau 2007 Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis Am J Physiol 292 E1265 E1269
5. M Roden 2006 Mechanisms of disease review: hepatic steatosis in type 2 diabetes: mechanisms and clinical relevance Nature Cl Pract En 2 335 348
6. R Belfort SA Harrison K Brown C Darland J Finch J Hardies B Balas A Gastaldelli F Tio J Pulcini R Berria JZ Ma S Dwivedi R Havranek C Fincke R DeFronzo GA Bannayan S Schenker K Cusi 2006 A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis N Engl J Med 355 2297 2307
7. R Englisch R Wurzinger C Fürnsinn B Schneider H Frisch W Waldhäusl J Graf M Roden 2000 Effects of insulin-like growth factor I on basal and stimulated glucose fluxes in rat liver Biochem J 351 39 45
8. M Nemecz K Preininger R Englisch C Fürnsinn B Schneider W Waldhäusl M Roden 1999 Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver Hepatology 29 166 172
9. M Roden H Stingl V Chandramouli WC Schumann A Hofer BR Landau P Nowotny W Waldhäusl GI Shulman 2000 Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in man Diabetes 49 401 407
10. C Anderwald B Brunmair K Stadlbauer M Krebs C Fürnsinn M Roden 2007 Effects of free fatty acids on fasting glucose production, lactate uptake and insulin signal transduction in the isolated perfused rat liver Eur J Clin Invest 37 774 782
11. M Roden C Anderwald C Fürnsinn W Waldhäusl A Lohninger 2000 Effects of short-term leptin exposure on triglyceride deposition in rat liver Hepatology 32 1045 1049
12. C Anderwald G Müller G Koca C Fürnsinn W Waldhäusl M Roden 2002 Leptin-dependent inhibition of hepatic gluconeogenesis is modulated by insulin receptor substrate-2 Mol Endocrinol 16 1612 1628
13. + balance and bile flow Cell Calcium 30 403 412 doi: 10.1054/ceca.2001.0248
14. G Brabant H Nave R Horn C Anderwald G Müller M Roden 2004 In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats Europ J Clin Invest 34 831 837
15. G Brabant G Müller R Horn M Roden H Nave 2005 Hepatic leptin signalling in obesity FASEB J 19 1048 1050
16. K Preininger H Stingl R Englisch C Fürnsinn J Graf W Waldhäusl M Roden 1999 Acute troglitazone action in isolated perfused rat liver Br J Pharmacol 126 372 378