Methionine-adequate cysteine-free diet does not limit erythrocyte glutathione synthesis in young healthy adult men

Journal of Nutrition

Volumn 138, Issue 11, 2008, Pages 2172-2178

  Courtney Martin, Glenda ^a,b   Rafii, Mahroukh ^a   Wykes, Linda J ^c   Ball, Ronald O ^b,d   Pencharz, Paul B ^a,b,d  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CYSTEINE; GLYCINE; METHIONINE; MULTIVITAMIN; SULFATE;

ADULT; ARTICLE; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; DIETARY INTAKE; GLUTATHIONE METABOLISM; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; URINALYSIS;

ADULT; CROSS-OVER STUDIES; CYSTEINE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; GLUTATHIONE; HUMANS; MALE; METHIONINE;

EID: 55949128027     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.093302     Document Type: Article

References (32)

1. Stipanuk MH. Metabolism of sulfur-containing amino acids. Annu Rev Nutr. 1986;6:179-209.
2. Griffith OW. Mammalian sulfur amino acid metabolism: an overview. Methods Enzymol. 1987;143:366-76.
3. Meister A, Anderson ME. Glutathione. Annu Rev Biochem. 1983;52:711-60.
4. Stipanuk MH, Coloso RM, Garcia RA, Banks MF. Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes. J Nutr. 1992;122:420-7.
5. Kwon YH, Stipanuk MH. Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes. Am J Physiol Endocrinol Metab. 2001;280:E804-15.
6. Lyons J, Rauh-Pfeiffer A, Yu YM, Lu XM, Zurakowski D, Tompkins RG, Ajami AM, Young VR, Castillo L. Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet. Proc Natl Acad Sci USA. 2000;97:5071-6.
7. Jackson AA, Gibson NR, Lu Y, Jahoor F. Synthesis of erythrocyte glutathione in healthy adults consuming the safe amount of dietary protein. Am J Clin Nutr. 2004;80:101-7.
8. Badaloo A, Reid M, Forrester T, Heird WC, Jahoor F. Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition. Am J Clin Nutr. 2002;76:646-52.
9. Reid M, Badaloo A, Forrester T, Morlese JF, Frazer M, Heird WC, Jahoor F. In vivo rates of erythrocyte glutathione synthesis in children with severe protein-energy malnutrition. Am J Physiol Endocrinol Metab. 2000;278:E405-12.
10. Jahoor F, Jackson A, Gazzard B, Philips G, Sharpstone D, Frazer ME, Heird W. Erythrocyte glutathione deficiency in symptom-free HIV infection is associated with decreased synthesis rate. Am J Physiol. 1999;276:E205-11.
11. Reid M, Badaloo A, Forrester T, Jahoor F. In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease. Am J Physiol Endocrinol Metab. 2006;291:E73-9.
12. Hunter EA, Grimble RF. Cysteine and methionine supplementation modulate the effect of tumor necrosis factor alpha on protein synthesis, glutathione and zinc concentration of liver and lung in rats fed a low protein diet. J Nutr. 1994;124:2319-28.
13. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr. 2006;136:S1652-9.
14. Kurpad AV, Regan MM, Varalakshmi S, Gnanou J, Young VR. Daily requirement for total sulfur amino acids of chronically undernourished Indian men. Am J Clin Nutr. 2004;80:95-100.
15. Lee JI, Londono M, Hirschberger LL, Stipanuk MH. Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level. J Nutr Biochem. 2004;15:112-22.
16. Zello GA, Ball RO. The design and validation of a diet for studies of amino acid metabolism in adult humans. Nutr Res. 1990;10:1353-65.
17. Geigy C. Scientific tables. 7th ed. Basle (Switzerland): Ciba-Geigy Limited; 1970.
18. Food and Nutrition Board IoM. Dietary reference intakes: thiamin, riboflavin, niacin, vitamin B-6, vitamin B-12, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press; 1998.
19. Kurpad AV, Regan MM, Varalakshmi S, Vasudevan J, Gnanou J, Raj T, Young VR. Daily methionine requirements of healthy Indian men, measured by a 24-h indicator amino acid oxidation and balance technique. Am J Clin Nutr. 2003;77:1198-205.
20. Storch KJ, Wagner DA, Burke JF, Young VR. Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]- and [1-13C]methionine. Am J Physiol. 1988;255:E322-31.
21. Di Buono M, Wykes LJ, Ball RO, Pencharz PB. Total sulfur amino acid requirement in young men as determined by indicator amino acid oxidation with L-[1-13C]phenylalanine. Am J Clin Nutr. 2001;74:756-60.
22. Rose WC, Coon MJ, Lockhart HB, Lambert GF. The amino acid requirements of man. XI. The threonine and methionine requirements. J Biol Chem. 1955;215:101-10.
23. Zello GA, Smith JM, Pencharz PB, Ball RO. Development of a heating device for sampling arterialized venous blood from a hand vein. Ann Clin Biochem. 1990;27:366-72.
24. Swaroop A. A micromethod for the determination of urinary inorganic sulfates. Clin Chim Acta. 1973;46:333-6.
25. Jahoor F, Wykes LJ, Reeds PJ, Henry JF, del Rosario MP, Frazer ME. Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. J Nutr. 1995;125:1462-72.
26. FAO/WHO/UNU. Energy and protein requirements. Report of a joint FAO/WHO/UNU expert consultation. World Health Organ Tech Rep Ser. 1985;724:1-206.
27. Humayun MA, Elango R, Ball RO, Pencharz PB. Reevaluation of the protein requirement in young men with the indicator amino acid oxidation technique. Am J Clin Nutr. 2007;86:995-1002.
28. Bella DL, Hahn C, Stipanuk MH. Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism. Am J Physiol. 1999;277:E144-53.
29. Bella DL, Hirschberger LL, Hosokawa Y, Stipanuk MH. Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. Am J Physiol. 1999;276:E326-35.
30. Stipanuk MH, Londono M, Lee JI, Hu M, Yu AF. Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. J Nutr. 2002;132:3369-78.
31. Malmezat T, Breuille D, Pouyet C, Buffiere C, Denis P, Mirand PP, Obled C. Methionine transsulfuration is increased during sepsis in rats. Am J Physiol Endocrinol Metab. 2000;279:E1391-7.
32. Malmezat T, Breuille D, Capitan P, Mirand PP, Obled C. Glutathione turnover is increased during the acute phase of sepsis in rats. J Nutr. 2000;130:1239-46.