In vivo rates of erythrocyte glutathione synthesis in children with severe protein-energy malnutrition

American Journal of Physiology - Endocrinology and Metabolism

Volumn 278, Issue 3 41-3, 2000, Pages

  Reid, Marvin ^a,b   Badaloo, Asha ^b   Forrester, Terrence ^b   Morlese, John F ^a,b   Frazer, Margaret ^a   Heird, William C ^a   Jahoor, Farook ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF THE WEST INDIES   (Jamaica)

Author keywords

Cysteine; Kwashiorkor; Lipid hydroperoxides; Marasmus; Stable isotope

Indexed keywords

CYSTEINE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; EDEMA; ERYTHROCYTE; GLUTATHIONE METABOLISM; HOMEOSTASIS; HUMAN; INFECTION; KWASHIORKOR; MARASMUS; OXIDATIVE STRESS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION;

EID: 0034097848     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.278.3.e405     Document Type: Article

References (27)

1. Bauman, P. F., T. K. Smith, and T. M. Bray. Effect of dietary protein deficiency and L-2-oxothiazolidine-4-carboxylate on the diurnal rhythm of hepatic glutathione in the rat. J. Nutr. 118: 1049-1054, 1988.
2. Becker, K., M. Leichsenring, L. Gana, H. J. Bremer, and R. H. Schirmer. Glutathione and association antioxidant systems in protein energy malnutrition: results of a study in Nigeria. Free Radic. Biol. Med. 18: 257-263, 1995.
3. Dramaix, M., P. Hennart, D. Brasseur, P. Bahwere, O. Mudjene, R. Tonglet, P. Donnen, and R. Smets. Serum albumin concentration, arm circumference, and oedema and subsequent risk of dying in children in central Africa. Br. Med. J. 307: 710-713, 1993.
4. Edozien, J. C., E. J. Phillips, and W. R. Collis. The free amino acids of plasma and urine in kwashiorkor. Lancet 1: 615-618, 1960.
5. Ghisolfi, J., P. Charlet, N. Ser, R. Salvayre, J. P. Thouvenot, and C. Duole. Plasma free amino acids in normal children and in patients with proteinocaloric malnutrition: fasting and infection. Pediatr. Res. 12: 912-917, 1978.
6. Golden, M. H., and D. Ramdath. Free radicals in the pathogenesis of kwashiorkor. Proc. Nutr. Soc. 46: 53-68, 1987.
7. Grimble, R. F., A. A. Jackson, C. Persaud, M. J. Wride, F. Delers, and R. Engler. Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet. J. Nutr. 122: 2066-2073, 1992 (published erratum appears in J. Nutr.123: 600, 1993).
8. Gutteridge, J. M. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem. 41: 1819-1828, 1995.
9. Hum, S., K. G. Koski, and L. J. Hoffer. Varied protein intake alters glutathione metabolism in rats. J. Nutr. 122: 2010-2018, 1992.
10. Hum, S., L. Robitaille, and L. J. Hoffer. Plasma glutathione turnover in the rat: effect of fasting and buthionine sulfoximine:. Can. J. Physiol. Pharmacol. 69: 581-587, 1991.
11. Hunter, E. A., and R. F. Grimble. Dietary sulphur amino acid adequacy influences glutathione synthesis and glutathione-dependent enzymes during the inflammatory response to endotoxin and tumour necrosis factor-alpha in rats. Clin. Sci. (Colch.) 92: 297-305, 1997.
12. Jackson, A., and M. Golden. Severe malnutrition. In: Oxford Textbook of Medicine, edited by D. Weatherall, J. Ledingham, and D. Warrel. Oxford: Oxford Univ. Press, 1988, p. 12-23.
13. Jackson, A. A. Blood glutathione in severe malnutrition in childhood. Trans. R. Soc. Trop. Med. Hyg. 80: 911-913, 1986.
14. Jahoor, F., L. J. Wykes, P. J. Reeds, J. F. Henry, M. P. del Rosario, and M. E. Frazer. Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. J. Nutr. 125: 1462-1472, 1995.
15. Lenhartz, H., R. Ndasi, A. Anninos, D. Botticher, E. Mayatepek, E. Tetanye, and M. Leichsenring. The clinical manifestation of the kwashiorkor syndrome is related to increased lipid peroxidation. J. Pediatr. 132: 879-881, 1998.
16. Manary, M. J., R. L. Broadhead, and K. E. Yarasheski. Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. Am. J. Clin. Nutr. 67: 1205-1209, 1998.
17. Meister, A. Metabolism and function of glutathione. Coenzymes and cofactors. In: Glutathione, Chemical, Biochemical, and Medical Aspects, edited by D. Dolphin, O. Avramovic, and R. Poulson. New York: Wiley, 1988, p. 367-474.
18. Milliken, G. A., and D. E. Johnson. Analysis of repeated measures designs for which the usual assumptions hold. In: Analysis of Messy Data: Designed Experiments. New York: Reinhold, 1984, vol. 1, p. 322-350.
19. Niki, E., Y. Yamamoto, E. Komuro, and K. Sato. Membrane damage due to lipid oxidation. Am. J. Clin. Nutr. 53: 201S-205S, 1991.
20. Nourooz-Zadeh, J., J. Tajaddini-Sarmadi, and S. P. Wolff. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal. Biochem. 220: 403-409, 1994.
21. Persaud, C., T. Forrester, and A. A. Jackson. Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine. J. Nutr. 126: 2823-2830, 1996.
22. Prudhon, C., A. Briend, D. Laurier, M. H. Golden, and J. Y. Mary. Comparison of weight-and height-based indices for assessing the risk of death in severely malnourished children. Am. J. Epidemiol. 144: 116-123, 1996.
23. Ramdath, D. D., and M. H. Golden. Elevated glutathione S-transferase activity in erythrocytes from malnourished children. Eur. J. Clin. Nutr. 47: 658-665, 1993.
24. Roediger, W. E. New views on the pathogenesis of kwashiorkor: methionine and other amino acids. J. Pediatr. Gastroenterol. Nutr. 21: 130-136, 1995.
25. Waterlow, J. C. Protein-Energy Malnutrion. London: Edward Arnold, 1992.
26. Wellcome Working Party. Classification of infantile malnutrition. Lancet 2: 302-303, 1970.
27. White, A., V. Thannickal, and B. Fanburg. Glutathione deficiency in human disease. J. Nutr. Biochem. 5: 218-216, 1994.