Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: Synthesis and evaluation for antimalarial, β-haematin inhibition, and cytotoxic activity

ChemMedChem

Volumn 3, Issue 11, 2008, Pages 1649-1653

  October, Natasha ^a   Watermeyer, Nicholas D ^a   Yardley, Vanessa ^b   Egan, Timothy J ^a   Ncokazi, Kanyile ^a   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Dihydropyrimidinones; Drug design; Quinoline containing antimalarials; Reversing agents; Sensitizers

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; HEMOPROTEIN; HEMOZOIN; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; IC 50; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIMALARIALS; CHEMISTRY, PHARMACEUTICAL; CHLOROQUINE; DRUG DESIGN; HEMEPROTEINS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55949121913     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800172     Document Type: Article

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