Synthesis and antiviral evaluation of novel 2,3-dihydroxypropyl nucleosides from 2- and 4-thiouracils

Nucleosides, Nucleotides and Nucleic Acids

Volumn 27, Issue 12, 2008, Pages 1257-1271

  Abdel Rahman, Adel A H ^a   El Etrawy, Abd Allah Sh ^a   Abdel Megied, Ahmed E S ^a   Zeid, Ibrahim F ^a   El Ashry, El Sayed H ^b  

^a Menoufia University   (Egypt)

^b Alexandria University Faculty Of Science   (Egypt)

Author keywords

2,3 dihydroxypropyl nucleosides; 2 (methylthio) pyrimidin 4(1H) ones; 4 (methylthio)pyrimidin 2(1H) ones; Acyclic nucleosides; Antiviral agents; Hepatitis B

Indexed keywords

1 (2,3 DIHYDROXYPROPYL) 2 (METHYLTHIO) 5 METHYLPYRIMIDIN 4(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 2 (METHYLTHIO) 6 METHYLPYRIMIDIN 4(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 2 (METHYLTHIO)PYRIMIDIN 4(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 2 [(2,3 DIHYDROXYPROPYL)THIO] 5 METHYLPYRIMIDIN 4(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 2 [(2,3 DIHYDROXYPROPYL)THIO] 6 METHYLPYRIMIDIN4(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 2 [(2,3 DIHYDROXYPROPYL)THIO]PYRIMIDIN 4(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 4 (METHYLTHIO) 5 METHYLPYRIMIDIN 2(1H) ONES; 1 (2,3 DIHYDROXYPROPYL) 4 (METHYLTHIO)PYRIMIDIN 2(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 4 [(2,3 DIHYDROXYPROPYL)THIO] 5 METHYLPYRIMIDIN 2(1H) ONE; 1 (2,3 DIHYDROXYPROPYL) 4 [(2,3 DIHYDROXYPROPYL)THIO]PYRIMIDIN 2(1H) ONE; 2,3 DIHYDROXYPROPYL NUCLEOSIDE DERIVATIVE; 2,4 BIS[(2,3 DIHYDROXYPROPYL)THIO] 5 METHYLPYRIMIDINE; 2,4 BIS[(2,3 DIHYDROXYPROPYL)THIO] 6 METHYLPYRIMIDINE; 2,4 BIS[(2,3 DIHYDROXYPROPYL)THIO]PYRIMIDINE; 4 THIOURACIL; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DEPROTECTION REACTION; DRUG SYNTHESIS; ENZYME ACTIVITY; HEPATITIS B VIRUS; IC 50; NONHUMAN; STEREOCHEMISTRY;

ANTIVIRAL AGENTS; HEPATITIS B VIRUS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NUCLEOSIDES; THIOURACIL;

HEPATITIS B VIRUS;

EID: 55949094050     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770802086898     Document Type: Article

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