Ozone production by amino acids contributes to killing of bacteria

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 44, 2008, Pages 16912-16917

  Yamashita, Kouhei ^a   Miyoshi, Takashi ^a   Arai, Toshiyuki ^a   Endo, Nobuyuki ^b   Itoh, Hiroshi ^c   Makino, Keisuke ^c   Mizugishi, Kiyomi ^d   Uchiyama, Takashi ^a   Sasad, Masataka ^c  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b WAKASA WAN ENERGY RESEARCH CENTER   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

Chronic granulomatous disease; Host defense; Neutrophil; Singlet oxygen

Indexed keywords

AMINO ACID; ISATIN; OZONE; REACTIVE OXYGEN METABOLITE; SINGLET OXYGEN; SULFONIC ACID DERIVATIVE; SUPEROXIDE;

ARTICLE; BACTERICIDAL ACTIVITY; CATALYSIS; CELL FREE SYSTEM; CHEMICAL ANALYSIS; CHEMOLUMINESCENCE; ESCHERICHIA COLI; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOST RESISTANCE; HUMAN; HUMAN CELL; MICROORGANISM; NEUTROPHIL; NONHUMAN; OXIDATION; PHAGOCYTOSIS; PRIORITY JOURNAL;

ADULT; AMINO ACIDS; ANTI-BACTERIAL AGENTS; CATALYSIS; ESCHERICHIA COLI; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; HYDROGEN PEROXIDE; MALE; NEUTROPHILS; OXIDANTS; OXIDATION-REDUCTION; OZONE; REACTIVE OXYGEN SPECIES; SINGLET OXYGEN;

EID: 55949089201     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807952105     Document Type: Article

References (29)

1. Williams R (2006) Killing controversy. J Exp Med 203:2404.
2. Wentworth P, Jr, et al. (2002) Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science 298:2195-2199.
3. Babior BM, Takeuchi C, Ruedi J, Gutierrez A, Wentworth P, Jr (2003) Investigating antibody-catalyzed ozone generation by human neutrophils. Proc Natl Acad Sci USA 100:3031-3034.
4. Nieva J, Wentworth P, Jr (2004) The antibody-catalyzed water oxidation pathway: A new chemical arm to immune defense? Trends Biochem Sci 29:274-278.
5. Kettle AJ, Clark BM, Winterbourn CC (2004) Superoxide converts indigo carmine to isatin sulfonic acid: Implications for the hypothesis that neutrophils produce ozone. J Biol Chem 279:18521-18525.
6. Kettle AJ, Winterbourn CC (2005) Do neutrophils produce ozone? An appraisal of current evidence. Biofactors 24:41-45.
7. Malech HL (1993) Phagocyte oxidative mechanisms. Curr Opin Hematol 1:123-132.
8. Weening RS, Adriaansz LH, Weemaes CM, Lutter R, Roos D (1985) Clinical differences in chronic granulomatous disease in patients with cytochrome b-negative or cytochrome b-positive neutrophils. J Pediatr 107:102-104.
9. Yamada H, et al. (2005) Photodynamic effects of a novel pterin derivative on a pancreatic cancer cell line. Biochem Biophys Res Commun 333:763-767.
10. Sommani P, et al. (2007) Effects of edaravone on singlet oxygen released from activated human neutrophils. J Pharmacol Sci 103:117-120.
11. Vowells SJ, et al. (1996) Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease. J Pediatr 128:104-107.
12. -. Anal Biochem 159:363-369.
13. Posner GH, et al. (1984) A chemiluminescent probe specific for singlet oxygen. Biochem Biophys Res Commun 123:869-873.
14. Teixeira MM, Cunha FQ, Noronha-Dutra A, Hothersall J (1999) Production of singlet oxygen by eosinophils activated in vitro by C5a and leukotriene B4. FEBS Lett 453:265-268.
15. Yamashita K, et al. (2001) 6-Formylpterin intracellularly generates hydrogen peroxide and restores the impaired bactericidal activity of human neutrophils. Biochem Biophys Res Commun 289:85-90.
16. Klebanoff SJ (2005) Myeloperoxidase: Friend and foe. J Leukocyte Biol 77:598-625.
17. Parry MF, et al. (1981) Myeloperoxidase deficiency: Prevalence and clinical significance. Ann Intern Med 95:293-301.
18. Suzuki K, Muso E, Nauseef WM (2004) Contribution of peroxidases in host-defense, diseases, and cellular functions. Jpn J Infect Dis 57:S1-S2.
19. Lehrer RI, Cline MJ (1969) Leukocyte myeloperoxidase deficiency and disseminated candidiasis: The role of myeloperoxidase in resistance to Candida infection. J Clin Invest 48:1478-1488.
20. Nguyen C, Katner HP (1997) Myeloperoxidase deficiency manifesting as pustular candida dermatitis. Clin Infect Dis 24:258-260.
21. Aratani Y, et al. (1999) Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun 67:1828-1836.
22. Aratani Y, et al. (2000) Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase. J Infect Dis 182:1276-1279.
23. Dolmans DE, Fukumura D, Jain RK (2003) Photodynamic therapy for cancer. Nat Rev Cancer 3:380-387.
24. Maisch T (2007) Antimicrobial photodynamic therapy: Useful in the future? Lasers Med Sci 22:83-91.
25. Roos D, et al. (1996) Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease. Blood 87:1663-1681.
26. Moriguchi T, et al. (1990) Studies of the functions of polymorphonuclear leukocytes obtained from human bone marrow. Acta Hematol Jpn 53:668-677.
27. Zhou M, Panchuk-Voloshina N (1997) A 1-step fluorometric method for the continuous measurement of monoamine oxidase activity. Anal Biochem 253:169-174.
28. Asagoe K, et al. (1998) Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-α. J Immunol 160:4518-4525.
29. Johnston RB, Jr, et al. (1975) The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. J Clin Invest 55:1357-1372.