Taurocholate-induced nitric oxide signaling and the ensuing production of reactive oxygen species lead to an increase in epithelial permeability in cultivated mouse gastric epithelium

Digestive Diseases and Sciences

Volumn 53, Issue 12, 2008, Pages 3119-3127

  Mustonen, Harri ^a   Kiviluoto, Tuula ^a   Puolakkainen, Pauli ^a,b   Paimela, Hannu ^a   Mentula, Panu ^a   Kemppainen, Esko ^a   Kivilaakso, Eero ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Gastric mucosa; Nitric monoxide; Reactive oxygen species; Ulcerogenic agents

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; ANTIOXIDANT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TAUROCHOLIC ACID;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIUM CELL; MEMBRANE PERMEABILITY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; STOMACH MUCOSA; STOMACH ULCER; ULCEROGENESIS;

ANIMALS; ANTIOXIDANTS; ASPIRIN; CALCIUM SIGNALING; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CHOLAGOGUES AND CHOLERETICS; CYCLOOXYGENASE INHIBITORS; EPITHELIUM; ETHANOL; GASTRIC MUCOSA; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SOLVENTS; TAUROCHOLIC ACID;

EID: 55949088468     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0300-4     Document Type: Article

References (30)

1. T Kiviluoto S Watanabe M Hirose N Sato H Mustonen P Puolakkainen M Ronty T Ranta-Knuuttila E Kivilaakso 2001 Nitric oxide donors retard wound healing in cultured rabbit gastric epithelial cell monolayers Am J Physiol Gastrointest Liver Physiol 281 G1151 G1157
2. HH Bjorne J Petersson M Phillipson E Weitzberg L Holm JO Lundberg 2004 Nitrite in saliva increases gastric mucosal blood flow and mucus thickness J Clin Invest 113 106 114
3. J Petersson M Phillipson EA Jansson A Patzak JO Lundberg L Holm 2007 Dietary nitrate increases gastric mucosal blood flow and mucosal defense Am J Physiol Gastrointest Liver Physiol 292 G718 G724 10.1152/ajpgi.00435.2006
4. P Holzer C Wachter A Heinemann M Jocic IT Lippe MK Herbert 1995 Sensory nerves, nitric oxide and NANC vasodilatation Arch Int Pharmacodyn Ther 329 67 79
5. Tepperman BL, Jacobson ED (1994) Circulatory factors in gastric mucosal defence and repair. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 1331-1351
6. ME Stark JH Szurszewski 1992 Role of nitric oxide in gastrointestinal and hepatic function and disease Gastroenterology 103 1928 1949
7. VJ Thannickal BL Fanburg VJ Thannickal BL Fanburg 2000 Reactive oxygen species in cell signaling Am J Physiol Lung Cell Mol Physiol 279 L1005 L1028
8. N Sugiyama Y Tabuchi T Horiuchi M Obinata M Furusawa 1993 Establishment of gastric surface mucous cell lines from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene Exp Cell Res 209 382 387 10.1006/excr.1993.1324
9. EP Garvey JA Oplinger ES Furfine RJ Kiff F Laszlo BJ Whittle RG Knowles EP Garvey JA Oplinger ES Furfine RJ Kiff F Laszlo BJ Whittle RG Knowles 1997 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo J Biol Chem 272 4959 4963 10.1074/jbc.272.8.4959
10. A Yanaka H Muto H Fukutomi S Ito W Silen 1995 Role of nitric oxide in restitution of injured guinea pig gastric mucosa in vitro Am J Physiol 268 G933 G942
11. K Takeuchi S Kato T Yasuhiro K Yagi 1997 Mechanism of acid secretory changes in rat stomach after damage by taurocholate: role of nitric oxide, histamine, and sensory neurons Dig Dis Sci 42 645 653 10.1023/A:1018875932503
12. K Takeuchi S Kato K Takehara Y Asada T Yasuiro 1997 Role of nitric oxide in mucosal blood flow response and the healing of HCl-induced lesions in the rat stomach Digestion 58 19 27
13. K Takeuchi S Okabe 1995 Mechanism of gastric alkaline response in the stomach after damage. Roles of nitric oxide and prostaglandins Dig Dis Sci 40 865 871 10.1007/BF02064993
14. O Furukawa M Kitamura S Sugamoto K Takeuchi 1999 Stimulatory effect of nitric oxide on bicarbonate secretion in bullfrog duodenums in vitro Digestion 60 324 331 10.1159/000007678
15. N Benjamin F O'Driscoll H Dougall C Duncan L Smith M Golden H McKenzie 1994 Stomach NO synthesis Nature 368 502 10.1038/368502a0
16. Mustonen H, Puolakkainen P, Kemppainen E, Kiviluoto T, Kivilaakso E (2008) Taurocholate potentiates ethanol induced NF-κB activation and inhibits Caspase-3 activity in cultured rat gastric mucosal cells. Dig Dis Sci Submitted
17. H Yamamoto A Tanaka T Kunikata T Hirata S Kato K Takeuchi 1999 Inducible types of cyclooxygenase and nitric oxide synthase in adaptive cytoprotection in rat stomachs J Physiol Paris 93 405 412 10.1016/S0928-4257(99)00128-X
18. S Bidel H Mustonen G Khalighi-Sikaroudi E Lehtonen P Puolakkainen T Kiviluoto E Kivilaakso 2005 Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells World J Gastroenterol 11 4032 4039
19. B Brune 2005 The intimate relation between nitric oxide and superoxide in apoptosis and cell survival Antioxid Redox Signal 7 497 507 10.1089/ars.2005.7.497
20. S Kwiecien T Brzozowski SJ Konturek 2002 Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury J Physiol Pharmacol 53 39 50
21. H Sugata T Ueno T Shimosegawa T Yoshimura 2003 Direct detection of nitric oxide and its roles in maintaining gastric mucosal integrity following ethanol-induced injury in rats Free Radic Res 37 159 169 10.1080/ 1071576021000036461
22. E Masuda S Kawano K Nagano S Tsuji Y Takei M Tsujii M Oshita T Michida I Kobayashi A Nakama E Masuda S Kawano K Nagano S Tsuji Y Takei M Tsujii M Oshita T Michida I Kobayashi A Nakama 1995 Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats Gastroenterology 108 58 64 10.1016/0016-5085(95)90008-X
23. PC Konturek J Kania EG Hahn JW Konturek PC Konturek J Kania EG Hahn JW Konturek 2006 Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase J Physiol Pharmacol 57 Suppl 5 125 136
24. Y Mashita M Taniguchi A Yokota A Tanaka K Takeuchi Y Mashita M Taniguchi A Yokota A Tanaka K Takeuchi 2006 Oral but not parenteral aspirin upregulates COX-2 expression in rat stomachs. a relationship between COX-2 expression and PG deficiency Digestion 73 124 132 10.1159/000094098
25. H Mustonen A Hietaranta P Puolakkainen E Kemppainen H Paimela T Kiviluoto E Kivilaakso 2007 Ethanol induced NF-κB activation protects against cell injury in cultured rat gastric mucosal epithelium Am J Physiol Gastrointest Liver Physiol 292 G1614 G1621 10.1152/ajpgi.00273.2006
26. A Roveri M Coassin M Maiorino A Zamburlini FT van Amsterdam E Ratti F Ursini A Roveri M Coassin M Maiorino A Zamburlini FT van Amsterdam E Ratti F Ursini 1992 Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells Arch Biochem Biophys 297 265 270 10.1016/0003-9861(92)90671-I
27. 2+, closes gap junctions and decreases cell volume in rabbit gastric mucosa. In: Poujeol P, Petersen O (eds) Proceedings of the 3rd FEPS congress-federation of European physiological societies. Monduzzi, Bologna, pp 103-108
28. 2+ signalling pathway in cultured rabbit gastric epithelial cells Scand J Gastroenterol 39 104 110 10.1080/00365520310007855
29. H Mustonen T Kiviluoto H Paimela P Puolakkainen E Kivilaakso 2005 Calcium signaling is involved in ethanol induced volume decrease and gap junction closure in cultured rat gastric mucosal cells Dig Dis Sci 50 103 110 10.1007/s10620-005-1286-9
30. TA Miller ER Kokoska GS Smith A Banan 2001 Role of calcium homeostasis in gastric mucosal injury and protection Life Sci 69 3091 3102 10.1016/S0024-3205(01)01415-1