The effect of pH on the polymer degradation and drug release from PLGA-mPEG microparticles

Journal of Applied Polymer Science

Volumn 109, Issue 1, 2008, Pages 475-482

  Li, Jin ^a   Jiang, Guoqiang ^a   Ding, Fuxin ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Degradation; Drug release kinetics; Hydrolysis; PLGA mPEG microparticles; Polymer composition; Release condition

Indexed keywords

ABS RESINS; ACIDS; AGGLOMERATION; CONTROLLED DRUG DELIVERY; DEGRADATION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FOURIER TRANSFORMS; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYMERS; THEOREM PROVING;

ACIDIC ENVIRONMENTS; BULK DEGRADATIONS; CARBOXYLIC GROUPS; CHAIN SCISSIONS; CRYSTALLINITY; DEGRADATION BEHAVIORS; DEGRADATION MECHANISMS; DEGRADATION PATTERNS; DIFFERENT MECHANISMS; DRUG RELEASE KINETICS; DRUG RELEASES; DRUG SOLUBILITIES; FOURIER TRANSFORM INFRARED SPECTRUMS; IN VITRO DRUG RELEASES; LACTIDE; MICRO PARTICLES; MICROPARTICLE SYSTEMS; MODEL DRUGS; PARTICLE AGGLOMERATIONS; PARTICLE SURFACES; PH CONDITIONS; PLGA-MPEG MICROPARTICLES; POLYMER COMPOSITION; POLYMER COMPOSITIONS; POLYMER DEGRADATIONS; RELEASE CONDITION; SURFACE DEGRADATIONS; TRANSPORT PATHS; WATER UPTAKES; WEIGHT LOSSES;

PH EFFECTS;

DEGRADATION; DRUG DELIVERY; MOLECULAR WEIGHT; PH; POLYETHYLENE GLYCOL; POLYMER; SOLUBILITY;

EID: 55849124765     PISSN: 00218995     EISSN: 10974628     Source Type: Journal    
DOI: 10.1002/app.28122     Document Type: Article

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