Hedgehog signaling in biliary fibrosis

Journal of Clinical Investigation

Volumn 118, Issue 10, 2008, Pages 3263-3265

  Greenbaum, Linda E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN;

BILIARY TRACT DISEASE; CELL PROLIFERATION; CELL TYPE; COCULTURE; FIBROGENESIS; LIVER INJURY; MYOFIBROBLAST; NONHUMAN; NOTE; PARACRINE SIGNALING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CHOLESTASIS, INTRAHEPATIC; EPITHELIUM; FIBROSIS; HEDGEHOG PROTEINS; HUMANS; LIVER CIRRHOSIS, BILIARY; MESODERM; MICE; PARACRINE COMMUNICATION; SIGNAL TRANSDUCTION;

EID: 55849113755     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI37189     Document Type: Note

References (13)

1. Xia, X., et al. 2007. Cholangiocyte injury and ductopenic syndromes. Semin. Liver Dis. 27:401-412.
2. Lazaridis, K.N., Strazzabosco, M., and Larusso, N.F. 2004. The cholangiopathies: disorders of biliary epithelia. Gastroenterology. 127:1565-1577.
3. Lee, J.M., Dedhar, S., Kalluri, R., and Thompson, E.W. 2006. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J. Cell Biol. 172:973-981.
4. Baum, B., Settleman, J., and Quinlan, M.P. 2008. Transitions between epithelial and mesenchymal states in development and disease. Semin. Cell Dev. Biol. 19:294-308.
5. Robertson, H., Kirby, J.A., Yip, W.W., Jones, D.E., and Burt, A.D. 2007. Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis. Hepatology. 45:977-981.
6. Rygiel, K.A., et al. 2008. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Lab. Invest. 88:112-123.
7. Diaz, R., et al. 2008. Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis. Hum. Pathol. 39:102-115.
8. Omenetti, A., et al. 2007. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab. Invest. 87:499-514.
9. Omenetti, A., et al. 2008. The hedgehog pathway regulates remodeling responses to biliary obstruction in rats. Gut. 57:1275-1282.
10. Huber, M.A., Kraut, N., and Beug, H. 2005. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17:548-558.
11. Li, X., Deng, W., Lobo-Ruppert, S.M., and Ruppert, J.M. 2007. Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin. Oncogene. 26:4489-4498.
12. Omenetti, A., et al. 2008. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J. Clin. Invest. 118:3331-3342.
13. Yovchev, M.I., et al. 2008. Identification of adult hepatic progenitor cells capable of repopulating injured rat liver. Hepatology. 47:636-647.