Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 285, Issue 5 54-5, 2003, Pages

  Nicklous, Danielle M ^a   Simansky, Kenny J ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Feeding; FMRFamide; Hyperphagia; Rats; opioid receptors

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; NALOXONE; NEUROPEPTIDE FF; OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ANTAGONISM; FOOD DEPRIVATION; FOOD INTAKE; HYPERPHAGIA; MALE; NONHUMAN; PARABRACHIAL NUCLEUS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

EID: 0142031649     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00107.2003     Document Type: Article

References (72)

1. Aarnisalo AA and Panula P. Neuropeptide FF-containing efferent projections from the medial hypothalamus of rat: a Phaseolus vulgaris leucoagglutinin study. Neuroscience 65: 175-192, 1995.
2. Allard M, Zajac JM, and Simonnet G. Autoradiographic distribution of receptors to FLFQPQRFamide, a morphine-modulating peptide, in rat central nervous system. Neuroscience 49: 101-116, 1992.
3. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
4. Arvidsson U, Dado RJ, Riedl M, Lee JH, Law PY, Loh HH, Elde R, and Wessendorf W. δ-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J Neurosci 15: 1215-1235, 1995.
5. Baird JP, Travers JB, and Travers SP. Parametric analysis of gastric distention responses in the parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol 281: R1568-R1580, 2001.
6. Baird JP, Travers SP, and Travers JB. Integration of gastric distension and gustatory responses in the parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol 281: R1581-R1593, 2001.
7. Bakshi VP and Kelley AE. Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes. J Pharmacol Exp Ther 265: 1253-1260, 1993.
8. Ballet S, Mauborgne A, Gouarderes C, Bourgoinn AS, Zajac JM, Hamon M, and Cesselin F. The neuropeptide FF analogue, 1DME, enhances in vivo met-enkephalin release from the rat spinal cord. Neuropharmacology 38: 1317-1324, 1999.
9. Bonini JA, Jones KA, Adham N, Forray C, Artmyshyn R, Durkin MM, Smith KE, Tamm JA, Boteju LW, Lakhlani PP, Raddatz R, Yao WJ, Ogozalek KL, Boyle N, Kouranova EV, Quan Y, Vaysse PJ, Weetzel JM, Branchek TA, Gerald C, and Borowsky B. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J Biol Chem 275: 39324-39331, 2000.
10. Cador M, Marco N, Stinus L, and Simonnet G. Interaction between neuropeptide FF and opioids in the ventral tegmental area in the behavioral response to novelty. Neuroscience 110: 309-318, 2002.
11. Calingasan NY and Ritter S. Lateral parabrachial subnucleus lesions abolish feeding induced by mercaptoacetate but not by 2-deoxy-D-glucose. Am J Physiol Regul Integr Comp Physiol 265: R1168-R1178, 1993.
12. Chamberlin NL, Mansour A, Watson SJ, and Saper CB. Localization of mu-opioid receptors on amygdaloid projection neurons in parabrachial nucleus of the rat. Brain Res 827: 198-204, 1999.
13. Chen X, Zidichouski JA, Harris KH, and Jhamandas JH. Synaptic actions of neuropeptide FF in the rat parabrachial nucleus: interactions with opioid receptors. J Neurophysiol 84: 744-751, 2000.
14. 3]NPFF. Synapse 24: 282-296, 1996.
15. Echo JA, Lamonte N, Ackerman TF, and Bodnar RJ. Alterations in food intake elicited by GABA and opioid agonists and antagonists administered into the ventral tegmental area regions of rats. Physiol Behav 76: 107-116, 2002.
16. Echo JA, Lamonte N, Christian G, Znamensky V, Ackerman TF, and Bodnar RJ. Excitatory amino acid receptor subtype agonists induce feeding in the nucleus accumbens shell in rats: opioid antagonist actions and interactions with μ-opioid agonists. Brain Res 921: 86-97, 2001.
17. Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, and Sarau HM. Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J Biol Chem 275: 25965-25971, 2000.
18. Giraudo S, Kotz CM, Billington CJ, and Levine AS. Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat. Brain Res 802: 184-188, 1998.
19. Goldstein A and Naidu A. Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Mol Pharmacol 36: 265-272, 1989.
20. Gouarderes C, Jhamandas K, Sutak M, and Zajac JM. Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues. Br J Pharmacol 117: 493-501, 1996.
21. 125I]EYF as selective radioligands. Neuroscience 115: 349-361, 2002.
22. Gouarderes C, Sutak M, Zajac JM, and Jhamandas K. Antinociceptive effects of intrathecally administered F8Famide and FMRFamide in the rat. Eur J Pharmacol 237: 73-81, 1993.
23. Gouarderes C, Tafani JAM, and Zajac JM. Affinity of neuropeptide FF analogs to opioid receptors in the rat spinal cord. Peptides 19: 727-730, 1998.
24. Guzman A, Legendre P, Allard M, Geoffe S, Vincent JD, and Simonnet G. Electrophysiological effects of FLFQPQRFamide, an endogenous brain morphine modulating peptide, on cultured mouse spinal-cord neurons. Neuropeptides 14: 253-261, 1989.
25. Hermann GE and Rogers RC. Convergence of vagal and gustatory afferent input within the parabrachial nucleus of the rat. J Auton Nerv Syst 13: 1-17, 1985.
26. Higgs A and Cooper SJ. Hyperphagia induced by direct administration of midazolam into the parabrachial nucleus of the rat. Eur J Pharmacol 313: 1-9, 1996.
27. Horn CC and Friedman MI. Methyl palmoxirate increases eating behavior and brain Fos-like immunoreactivity in rats. Brain Res 781: 8-14, 1998.
28. Huang EYK, Li JY, Wong CH, Tan PPC, and Chen JC. Dansyl-PQRamide, a possible neuropeptide FF receptor antagonist, induces place preference. Peptides 23: 489-496, 2002.
29. Jhamandas JH, Harris KH, Petrov T, Yang HYT, and Jhamandas KH. Activation of neuropeptide FF neurons in the brainstem nucleus tractus solitarius following cardiovascular challenge and opiate withdrawal. J Comp Neurol 402: 210-221, 1998.
30. Jhamandas JH, Jhamandas A, and Harris KH. New central projections of neuropeptide FF: colateral branching pathways in the brainstem and hypothalamus in the rat. J Chem Neuroanat 21: 171-179, 2001.
31. Karimnamazi H, Travers SP, and Travers JB. Oral and gastric input to the parabrachial nucleus of the rat. Brain Res 957: 193-206, 2002.
32. Kavaliers M and Hirst M. FMRFamide, a putative endogenous opiate antagonist: evidence from suppression of defeat-induced analgesia and feeding in mice. Neuropeptides 6: 485-494, 1985.
33. Kavaliers M and Hirst M. FMRFamide suppresses κ opiate induced feeding in the mouse. Peptides 6: 847-849, 1985.
34. Kavaliers M and Hirst M. FMRFamide: an endogenous peptide with marked inhibitory effects on opioid-induced feeding behavior. Brain Res Bull 17: 403-408, 1986.
35. Kavaliers M, Hirst M, and Mathers A. Inhibitory influences of FMRFamide on morphine- and deprivation-induced feeding. Neuroendocrinology 40: 533-535, 1985.
36. 2-related peptides augments morphine- and stress-induced analgesia in mice. Peptides 10: 741-745, 1989.
37. Kivipelto L, Majane EA, Yang HYT, and Panula P. Immunohistochemical distribution and partial characterization of FLFQPQRFamide-like peptides in the central nervous system of rats. J Comp Neurol 286: 269-287, 1989.
38. Kivipelto L and Panula P. Central neuronal pathways containing FLFQPQRFamide-like (morphine-modulating) peptides in the rat brain. Neuroscience 41: 137-148, 1991.
39. Kotz CM, Billington CJ, and Levine AS. Opioids in the nucleus of the solitary tract are involved in feeding in the rat. Am J Physiol Regul Integr Comp Physiol 272: R1028-R1032, 1997.
40. Lake JR, Hammond MV, Shaddox RC, Hunsicker LM, Yang HYT, and Malin DH. IgG from neuropeptide FF antiserum reverses morphine tolerance in the rat. Neurosci Lett 132: 29-32, 1991.
41. 1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136: 304-301, 1998.
42. Liu Q, Guan XM, Martin WJ, McDonald TP, Clements MK, Jiang Q, Zeng Z, Jacobson M, Williams DL Jr., Yu H, Bomford D, Figueroa D, Mallee J, Wang R, Evans J, Gould R, and Austin CP. Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. J Biol Chem 276: 36961-36969, 2001.
43. Mansour A, Fox CA, Thompson RC, Akil H, and Watson SJ. μ-Opioid receptor mRNA expression in the rat CNS: comparison to μ-receptor binding. Brain Res 643: 245-265, 1994.
44. Miller KK and Lupica CR. Neuropeptide FF inhibition of morphine effects in the rat hippocampus. Brain Res 750: 81-86, 1991.
45. Murase T, Arima H, Kondo K, and Oiso Y. Neuropeptide FF reduces food intake in rats. Peptides 17: 353-354, 1996.
46. Norgren R. Taste pathways to hypothalamus and amygdala. J Comp Neurol 166: 17-30, 1976.
47. Panula P, Kalso E, Nieminen ML, Kontinen VK, Brandt A, and Pertovaara A. Neuropeptide FF and modulation of pain. Brain Res 848: 191-196, 1999.
48. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates (4th ed.). New York: Academic, 1998.
49. Price DA and Greenberg MJ. Structure of a molluscan cardioexcitatory neuropeptide. Science 197: 670-671, 1977.
50. Quelven I, Roussin A, Burlet-Schiltz O, Gouarderes C, Tafani JAM, Mazarguil H, and Zajac JM. Dissociation of pharmacological pro- and anti-opioid effects by neuropeptide analogs. Eur J Pharmacol 449: 91-98, 2002.
51. 2b receptors. Peptides 15: 401-404, 1994.
52. 2+ channels in rat spinal ganglion neurones. Neuroreport 7: 2979-2981, 1996.
53. Reilly S and Trifunovic R. Lateral parabrachial nucleus lesions in the rat: aversive and appetitive gustatory conditioning. Brain Res Bull 52: 269-278, 2000.
54. Robert JJ, Orosco M, Rouch C, Jacquot C, and Cohen Y. Unexpected responses of the obese "cafeteria" rat to the peptide FMRF-amide. Pharmacol Biochem Behav 34: 341-344, 1989.
55. 2+ in mouse spinal ganglion neurons. Eur J Pharmacol 306: 291-295, 1996.
56. Roumy M and Zajac JM. Neuropeptide FF, pain and analgesia. Eur J Pharmacol 345: 1-11, 1998.
57. Roumy M and Zajac JM. Neuropeptide FF selectively attenuates the effects of nociception on acutely dissociated neurons of the rat dorsal raphe nucleus. Brain Res 845: 208-214, 1999.
58. Saper CB. Central autonomic system. In: The Rat Nervous System (2nd ed.), edited by Paxinos G. New York: Academic, 1995.
59. Simansky KJ and Nicklous DM. Parabrachial infusion of D-fenfluramine reduces food intake: blockade by the 5-HT1B antagonist SB-216641. Pharmacol Biochem Behav 71: 681-690, 2002.
60. Simansky KJ, Nicklous DM, Aloyo VJ, and Wilson JD. Parabrachial infusion of DAMGO selectively stimulates feeding by a naloxone-sensitive mechanism. Appetite 35: 309, 2000.
61. Söderpalm AHV and Berridge KC. The hedonic impact and intake of food are increased by midazolam microinjection in the parabrachial nucleus. Brain Res 877: 288-297, 2000.
62. Sunter D, Hewson AK, Lynam S, and Dickson SL. Intracerebroventricular injection of neuropeptide FF, an opioid modulating neuropeptide, acutely reduces food intake and stimulates water intake in the rat. Neurosci Lett 313: 145-148, 2001.
63. 2-like immunoreactivity. Proc Natl Acad Sci USA 81: 5002-5005, 1984.
64. Trifunovic R and Reilly S. Medial versus lateral parabrachial nucleus lesions in the rat: effects on cholecystokinin- and D-fenfluramine-induced anorexia. Brain Res 894: 288-296, 2001.
65. 2 opioid receptors in rat and guinea pig brain. Brain Res 562: 57-65, 1991.
66. Wilson JD, Nicklous DM, Aloyo VJ, and Simansky KJ. An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol 285: R1055-R1065, 2003.
67. Xia Y and Haddad GG. Ontogeny and distribution of opioid receptors in the rat brainstem. Brain Res 549: 181-193, 1991.
68. Xu M, Kontinen VK, Panula P, and Kalso E. Role of the δ-opioid receptor in (1DME)NPYF mediated antinociception. Peptides 22: 33-38, 2001.
69. Yamamoto T and Sawa K. Comparison of c-Fos-like immunoreactivity in the brainstem following intraoral and intragastric infusions of chemical solutions in rats. Brain Res 866: 144-151, 2000.
70. Yamamoto T, Shimura T, Sakai N, and Ozaki N. Representation of hedonics and quality of taste stimuli in the parabrachial nucleus of the rat. Physiol Behav 56: 1197-1202, 1994.
71. Yang HYT, Fratta W, Majane EA, and Costa E. Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine. Proc Natl Acad Sci USA 82: 7757-7761, 1985.
72. Znamensky V, Echo JA, Lamonte N, Christian G, Ragnauth A, and Bodnar RJ. γ-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats. Brain Res 906: 84-91, 2001.