Soy extract is more potent than genistein on tumor growth inhibition

Anticancer Research

Volumn 28, Issue 5 A, 2008, Pages 2837-2842

  Kim, Hyeon A ^a   Jeong, Kyu Shik ^b   Kim, Yoo Kyeong ^b  

^a Mokpo National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

Genistein; MDA MB 231 cell; Nude mice; Soy extract; Tumor growth

Indexed keywords

CYCLINE; DIMETHYL SULFOXIDE; GENISTEIN; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BREAST CANCER; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; DRUG POTENCY; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOYBEAN; TUMOR GROWTH;

ANIMALS; BODY WEIGHT; BREAST NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; FEMALE; GENISTEIN; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; PLANT EXTRACTS; SOYBEANS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 55749085657     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ferlay J, Bray F, Pisani P and Parkin DM: GLOBOCAN 2000: Cancer incidence, mortality and prevalence worldwide. In: IARC CancerBase No. 5. Version 1.0. Lyon, IARC Press. 2001.
2. Lee HP, Gourley L, Duffy SW, Esteve J, Lee J and Day NE: Dietary effects on breast-cancer risk in Singapore. Lancet 337(8751): 1197-1200, 1991.
3. Banerjee S, Li Y, Wang Z and Sarkar FH: Multi-targeted therapy of cancer by genistein. Cancer Lett, Epub ahead of print, 2008.
4. Duffy C, Perez K and Partridge A: Implications of phytoestrogen intake for breast cancer. CA Cancer J Clin 57(5): 260-277, 2007.
5. Dixon RA and Ferreira D: Genistein. Phytochemistry 60(3): 205-211, 2002.
6. Sarkar FH and Li Y: The role of isoflavones in cancer chemoprevention. Front Biosci 9: 2714-2724, 2004.
7. Sarkar FH and Li Y: Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev 21(3-4): 265-280, 2002.
8. Dip R, Lenz S, Antignac JP, Le Bizec B, Grauender H and Naegeli H: Global gene expression profiles induced by phytoestrogens in human breast cancer cells. Endocr Relat Cancer 15(1): 161-173, 2008.
9. Lavigne JA, Takahashi Y, Chandramouli GV, Liu H, Perkins SN, Bursting SD, Wang TT: Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. Breast Cancer Res Treat, Epub ahead of print, 2007.
10. Farina HG, Pomies M, Alonso DF and Gomez DE: Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer. Oncol Rep 16: 885-891, 2006.
11. Kousidou OC, Mitropoulou TN, Roussidis AE, Kletsas D, Theocharis AD and Karamanos NK: Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors. Int J Oncol 26(4): 1101-1109, 2005.
12. Zava DT and Duwe G: Estrogenic and antiproliferative properties of genistein and other flavanoids in human breast cancer cells in vitro. Nutr Cancer 27: 31-40, 1997.
13. Bail JC, Varnat F, Nicolas JC and Habrioux G: Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavanoids. Cancer Lett 130: 209-216, 1998.
14. Hsieh C, Santell RC, Haslam SZ and Helferich WG: Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 58: 3833-3838, 1998.
15. Chen WF, Huang MH, Tzang CH, Yang M and Wong MS: Inhibitory actions of genistein in human breast cancer (MCF-7) cells. Biochim Biophys Acta 1638(2): 187-196, 2003.
16. Li Y, Bhuiyan M and Sarkar FH: Induction of apoptosis and inhibition of C-ERBB-2 in MDA-MB-435 cells by genistein. Int J Oncol 15: 525-533, 1999.
17. Lamartiniere CA, Cotroneo MS, Fritz WA, Wang J, Mentor-Marcel R and Elgavish A: Genistein chemoprevention timing and mechanisms of action in mutine mammary and prostate. J Nutr 132(3):552S-558S, 2002.
18. Fritz WA, Coward L, Wang J and Lamartiniere CA: Dietary genistein perinatal mammary cancer prevention bioavailability and toxicity testing in the rat. Carcinogenesis 19(12): 2151-2158, 1998.
19. Cotroneo MS, Wang J, Fritz WA, Eltoum IE and Lamartiniere CA: Genistein action in the prepubertal mammary gland in a chemoprevention model. Carcinogenesis 23(9): 1467-1474, 2002.
20. Murrill WB, Brown NM, Manzolillo PA, Zhang JX, Barnes S and Lamartiniere CA: Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis 17: 1451-1457, 1996.
21. Hilakivi-Clarke L, Cho E, Onojafe I, Raygada M and Clarke R: Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol Rep 6: 1089-1095, 1999.
22. Hilakivi-Clarke L: Nutritional modulation of terminal end buds: its relevance to breast cancer prevention. Curr Cancer Drug Target 7(5): 465-474, 2007.
23. Allred CD, Allred KF, Ju YH, Goeppinger TS, Doerge DR and Helferich WG: Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis 25(9): 1649-1657, 2004.
24. Allred CD, Twaddle NC, Allred KF, Goeppinger TS, Churchwell MI, Ju YH, Helferich WG and Doerge DR: Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice. J Agric Food Chem 53(22): 8542-8550, 2005.
25. Allred CD, Ju YH, Allred KF, Chang J and Helferich WG: Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22: 1667-1673, 2001.
26. Allred CD, Allred KF, Ju YH, Virant SM and Helferich WG: Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res 61: 5045-5050, 2001.
27. Zhou JR, Yu L, Mai Z and Blackburn G: Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int J Cancer 108: 8-14, 2004.
28. Shao ZM, Wu J, Shen ZZ and Barsky SH: Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 58(21): 4851-4857, 1998.
29. Hewitt A and Singletary K: Soy extract inhibits mammary adenocarcinoma growth in syngeneic mouse model. Cancer Letters 192: 133-143, 2003.
30. Santell R, Kieu N and Helferich W: Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice. J Nutr 130: 1665-1669, 2000.
31. Yuan L, Wagatsuma C, Sun B, Kim JH and Surh YJ: The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells. Ann NY Acad Sci 1010: 347-359, 2003.
32. Gallo D, Ferlini C, Fabrizi M, Prislei S and Scambia G: Lack of stimulatory activity of a phytoestrogen-containing soy extract on the growth of breast cancer tumors in mice. Carcinogenesis 27(7): 1404-1409, 2006.