Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: Impact on amphotericin biosynthesis and implications for glycosylation engineering

Metabolic Engineering

Volumn 11, Issue 1, 2009, Pages 40-47

  Nic Lochlainn, Laura ^a   Caffrey, Patrick ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

GDP mannose biosynthesis; Natural products; Polyenes

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSTS; ENZYMES; GENES; GENETIC ENGINEERING; ORGANIC COMPOUNDS; PROTEINS; SUGAR (SUCROSE); SUGARS;

AGLYCONES; AMPHOTERICIN; ANTI CANCER AGENTS; ANTIFUNGAL; BLEOMYCIN; DOUBLE MUTANTS; GDP-MANNOSE BIOSYNTHESIS; GENE DISRUPTIONS; GLYCOLYTIC INTERMEDIATES; GLYCOSYLATED; GOOD YIELDS; HEXOKINASE; HYGROMYCIN; IN-VIVO; MANNOPEPTIMYCINS; NATURAL PRODUCTS; PHOSPHOMANNOSE ISOMERASE; PHOSPHOTRANSFERASE; POLYENES; STREPTOMYCETES; SUGAR RESIDUES; SYNTHESIS OF; TRACE LEVELS;

BIOCHEMICAL ENGINEERING;

AGLYCONE; AMPHOTERICIN; AMPHOTERICIN A; AMPHOTERICIN B; GUANOSINE DIPHOSPHATE MANNOSE; HEXOKINASE; MANNOSE PHOSPHATE ISOMERASE; PHOSPHOMANNOMUTASE; PHOSPHOTRANSFERASE; POLYENE;

ARTICLE; BIOSYNTHESIS; ENZYME SYNTHESIS; FUNGAL GENE; GENE DISRUPTION; GENE INACTIVATION; GLYCOSYLATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES NODOSUS;

AMPHOTERICIN B; ANTI-BACTERIAL AGENTS; GLYCOSYLATION; MANNOSE-6-PHOSPHATE ISOMERASE; MUTATION; NUCLEOTIDYLTRANSFERASES; PHOSPHOTRANSFERASES (PHOSPHOMUTASES); STREPTOMYCES;

STREPTOMYCES NODOSUS; STREPTOMYCINEAE;

EID: 55749083541     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2008.08.007     Document Type: Article

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