Smad signaling dynamics: Insights from a parsimonious model

Science Signaling

Volumn 1, Issue 36, 2008, Pages

  Shankaran, Harish ^a   Wiley, H Steven ^a,b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL NUCLEUS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL NUCLEUS; MODELS, BIOLOGICAL; PHOSPHORYLATION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD4 PROTEIN;

EID: 55649123317     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.136pe41     Document Type: Review

References (23)

1. R. Cheong, A. Levchenko, Wires in the soup: Quantitative models of cell signaling. Trends Cell Biol. 18, 112-118 (2008).
2. B. Di Ventura, C. Lemerle, K. Michalodimitrakis, L. Serrano, From in vivo to in silico biology and back. Nature 443, 527-533 (2006).
3. H. Kitano, Computational systems biology. Nature 420, 206-210 (2002).
4. H. S. Wiley, S. Y. Shvartsman, D. A. Lauffenburger, Computational modeling of the EGF-receptor system: A paradigm for systems biology. Trends Cell Biol. 13, 43-50 (2003).
5. B. Schmierer, A. L. Tournier, P. A. Bates, C. S. Hill, Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system. Proc. Natl. Acad. Sci. U.S.A. 105, 6608-6613 (2008).
6. H. Conzelmann, J. Saez-Rodriguez, T. Sauter, E. Bullinger, F. Allgower, E. D. Gilles, Reduction of mathematical models of signal transduction networks: Simulation-based approach applied to EGF receptor signalling. Syst. Biol. (Stevenage) 1, 159-169 (2004).
7. L. H. Hartwell, J. J. Hopfield, S. Leibler, A. W. Murray, From molecular to modular cell biology. Nature 402, C47-C52 (1999).
8. D. A. Lauffenburger, Cell signaling pathways as control modules: Complexity for simplicity? Proc. Natl. Acad. Sci. U.S.A. 97, 5031-5033 (2000).
9. J. Saez-Rodriguez, A. Kremling, E. D. Gilles, Dissecting the puzzle of life: Modularization of signal transduction networks. Comput. Chem. Eng. 29, 619-629 (2005).
10. 125I-labeled human epidermal growth factor: Binding, internalization, and degradation in human fibroblasts. J. Cell Biol. 71, 159-171 (1976).
11. C. H. Heldin, B. Westermark, A. Wasteson, Desensitisation of cultured glial cells to epidermal growth factor by receptor down-regulation. Nature 282, 419-420 (1979).
12. L. K. Opresko, H. S. Wiley, Functional reconstitutional of the human epidermal growth factor receptor system in Xenopus oocytes. J. Cell Biol. 111, 1661-1671 (1990).
13. H. Shankaran, H. Resat, H. S. Wiley, Cell surface receptors for signal transduction and ligand transport: A design principles study. PLoS Comput. Biol. 3, e101 (2007).
14. H. Shankaran, H. S. Wiley, H. Resat, Receptor downregulation and desensitization enhance the information processing ability of signalling receptors. BMC Syst. Biol. 1, 48 (2007).
15. J. A. Barnard, R. Graves-Deal, M. R. Pittelkow, R. DuBois, P. Cook, G. W. Ramsey, P. R. Bishop, L. Damstrup, R. J. Coffey, Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. J. Biol. Chem. 269, 22817-22822 (1994).
16. M. Samoilov, A. Arkin, J. Ross, Signal processing by simple chemical systems. J. Phys. Chem. A 106, 10205-10221 (2002).
17. H. El-Samad, H. Kurata, J. C. Doyle, C. A. Gross, M. Khammash, Surviving heat shock: Control strategies for robustness and performance. Proc. Natl. Acad. Sci. U.S.A. 102, 2736-2741 (2005).
18. D. M. Wolf, A. P. Arkin, Motifs, modules and games in bacteria. Curr. Opin. Microbiol. 6, 125-134 (2003).
19. T. M. Yi, Y. Huang, M. I. Simon, J. Doyle, Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc. Natl. Acad. Sci. U.S.A. 97, 4649-4653 (2000).
20. T. Ebisawa, M. Fukuchi, G. Murakami, T. Chiba, K. Tanaka, T. Imamura, K. Miyazono, Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276, 12477-12480 (2001).
21. K. Miyazono, Positive and negative regulation of TGF-beta signaling. J. Cell Sci. 113, 1101-1109 (2000).
22. J. M. Vilar, R. Jansen, C. Sander, Signal processing in the TGF-beta superfamily ligand-receptor network. PLoS Comput. Biol. 2, e3 (2006).
23. Z. Zi, E. Klipp, Constraint-based modeling and kinetic analysis of the Smad dependent TGF-beta signaling pathway. PLoS One 2, e936 (2007).