Pathogenetic mechanisms of coronary ectasia

International Journal of Cardiology

Volumn 130, Issue 3, 2008, Pages 335-343

  Antoniadis, Antonios P ^a   Chatzizisis, Yiannis S ^b   Giannoglou, George D ^a  

^a AHEPA UNIVERSITY HOSPITAL   (Greece)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Coronary atherosclerosis; Ectasia; Molecular biology; Vascular remodeling

Indexed keywords

C REACTIVE PROTEIN; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; LEUKOTRIENE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ANGIOCARDIOGRAPHY; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY ANEURYSM; CORONARY ECTASIA; CORONARY HEMODYNAMICS; DISEASE CLASSIFICATION; ENZYMATIC DEGRADATION; EXTRACELLULAR MATRIX; FALSE ANEURYSM; GENETIC PREDISPOSITION; HISTOPATHOLOGY; HUMAN; INFLAMMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; TRANSTHORACIC ECHOCARDIOGRAPHY;

CORONARY ARTERY DISEASE; CORONARY VESSELS; DILATATION, PATHOLOGIC; HUMANS; VENTRICULAR REMODELING;

EID: 55549125871     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2008.05.071     Document Type: Review

References (79)

1. Swaye P.S., Fisher L.D., Litwin P., et al. Aneurysmal coronary artery disease. Circulation 67 (1983) 134-138
2. Swanton R.H., Thomas M.L., Coltart D.J., Jenkins B.S., Webb-Peploe M.M., and Williams B.T. Coronary artery ectasia-a variant of occlusive coronary arteriosclerosis. Br Heart J 40 (1978) 393-400
3. Kruger D., Stierle U., Herrmann G., Simon R., and Sheikhzadeh A. Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms ("dilated coronopathy"). J Am Coll Cardiol 34 (1999) 1461-1470
4. Sayin T., Doven O., Berkalp B., Akyurek O., Gulec S., and Oral D. Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int J Cardiol 78 (2001) 143-149
5. Rath S., Har-Zahav Y., Battler A., et al. Fate of nonobstructive aneurysmatic coronary artery disease: angiographic and clinical follow-up report. Am Heart J 109 (1985) 785-791
6. Markis J.E., Joffe C.D., Cohn P.F., Feen D.J., Herman M.V., and Gorlin R. Clinical significance of coronary arterial ectasia. Am J Cardiol 37 (1976) 217-222
7. Dajani A.S., Taubert K.A., Takahashi M., et al. Guidelines for long-term management of patients with Kawasaki disease. Report from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 89 (1994) 916-922
8. Aqel R.A., Zoghbi G.J., and Iskandrian A. Spontaneous coronary artery dissection, aneurysms, and pseudoaneurysms: a review. Echocardiography 21 (2004) 175-182
9. Giannoglou G.D., Antoniadis A.P., Chatzizisis Y.S., Damvopoulou E., Parcharidis G.E., and Louridas G.E. Prevalence of ectasia in human coronary arteries in patients in northern Greece referred for coronary angiography. Am J Cardiol 98 (2006) 314-318
10. Syed M., and Lesch M. Coronary artery aneurysm: a review. Prog Cardiovasc Dis 40 (1997) 77-84
11. Sharma S.N., Kaul U., Sharma S., et al. Coronary arteriographic profile in young and old Indian patients with ischaemic heart disease: a comparative study. Indian Heart J 42 (1990) 365-369
12. Daoud A.S., Pankin D., Tulgan H., and Florentin R.A. Aneurysms of the coronary artery. Report of ten cases and review of literature. Am J Cardiol 11 (1963) 228-237
13. Manginas A., and Cokkinos D.V. Coronary artery ectasias: imaging, functional assessment and clinical implications. Eur Heart J 27 (2006) 1026-1031
14. Ge J., Liu F., Kearney P., et al. Intravascular ultrasound approach to the diagnosis of coronary artery aneurysms. Am Heart J 130 (1995) 765-771
15. Maehara A., Mintz G.S., Ahmed J.M., et al. An intravascular ultrasound classification of angiographic coronary artery aneurysms. Am J Cardiol 88 (2001) 365-370
16. Maehara A., Mintz G.S., Castagna M.T., et al. Intravascular ultrasound assessment of spontaneous coronary artery dissection. Am J Cardiol 89 (2002) 466-468
17. Weininger M., Meesmann M., Hahn D., and Beissert M. Assessment of a left coronary artery aneurysm with 64-channel multi-slice cardiac computed tomography. Eur J Cardiothorac Surg 30 (2006) 381-382
18. Chen J.K., Johnson P.T., and Fishman E.K. Detection of a fusiform coronary artery aneurysm using CT angiography. Emerg Radiol 13 (2006) 99-101
19. Mavrogeni S.I., Manginas A., Papadakis E., et al. Correlation between magnetic resonance angiography (MRA) and quantitative coronary angiography (QCA) in ectatic coronary vessels. J Cardiovasc Magn Reson 6 (2004) 17-23
20. Befeler B., Aranda M.J., Embi A., Mullin F.L., El-Sherif N., and Lazzara R. Coronary artery aneurysms: study of the etiology, clinical course and effect on left ventricular function and prognosis. Am J Med 62 (1977) 597-607
21. Valente S., Lazzeri C., Giglioli C., et al. Clinical expression of coronary artery ectasia. J Cardiovasc Med (Hagerstown) 8 (2007) 815-820
22. Endoh S., Andoh H., Sonoyama K., Furuse Y., Ohtahara A., and Kasahara T. Clinical features of coronary artery ectasia. J Cardiol 43 (2004) 45-52
23. Chatzizisis Y.S., Jonas M., Coskun A.U., et al. Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation 117 (2008) 993-1002
24. Kajinami K., Kasashima S., Oda Y., Koizumi J., Katsuda S., and Mabuchi H. Coronary ectasia in familial hypercholesterolemia: histopathologic study regarding matrix metalloproteinases. Mod Pathol 12 (1999) 1174-1180
25. Collins M.J., Borges A.J., Singh G., et al. A giant coronary artery aneurysm in the right coronary artery. Cardiovasc Pathol 15 (2006) 150-152
26. Glagov S., Weisenberg E., Zarins C.K., Stankunavicius R., and Kolettis G.J. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316 (1987) 1371-1375
27. Bentzon J.F., Pasterkamp G., and Falk E. Expansive remodeling is a response of the plaque-related vessel wall in aortic roots of apoE-deficient mice: an experiment of nature. Arterioscler Thromb Vasc Biol 23 (2003) 257-262
28. Chatzizisis Y.S., Coskun A.U., Jonas M., Edelman E.R., Feldman C.L., and Stone P.H. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 49 (2007) 2379-2393
29. Chatzizisis Y.S., Coskun A.U., Jonas M., Edelman E.R., Stone P.H., and Feldman C.L. Risk stratification of individual coronary lesions using local endothelial shear stress: a new paradigm for managing coronary artery disease. Curr Opin Cardiol 22 (2007) 552-564
30. Mason D.P., Kenagy R.D., Hasenstab D., et al. Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery. Circ Res 85 (1999) 1179-1185
31. Prescott M.F., Sawyer W.K., Von Linden-Reed J., et al. Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury. Ann N Y Acad Sci 878 (1999) 179-190
32. Carrell T.W., Burnand K.G., Wells G.M., Clements J.M., and Smith A. Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms. Circulation 105 (2002) 477-782
33. Pasterkamp G., Schoneveld A.H., Hijnen D.J., et al. Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteases 1, 2 and 9 in the human coronary artery. Atherosclerosis 150 (2000) 245-253
34. Lamblin N., Bauters C., Hermant X., Lablanche J.M., Helbecque N., and Amouyel P. Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease. J Am Coll Cardiol 40 (2002) 43-48
35. Liu J., Sukhova G.K., Yang J.T., et al. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis 184 (2006) 302-311
36. Schneiderman J., Bordin G.M., Engelberg I., et al. Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion. J Clin Invest 96 (1995) 639-645
37. Cheng X.W., Kuzuya M., Sasaki T., et al. Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointima of balloon-injured rat carotid arteries. Am J Pathol 164 (2004) 243-251
38. Dollery C.M., Owen C.A., Sukhova G.K., Krettek A., Shapiro S.D., and Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation 107 (2003) 2829-2836
39. Sukhova G.K., Wang B., Libby P., et al. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res 96 (2005) 368-375
40. Mabuchi H., Michishita I., Sakai Y., et al. Coronary ectasia in a homozygous patient with familial hypercholesterolemia. Atherosclerosis 59 (1986) 43-46
41. Genda A., Nakayama A., Shimizu M., et al. Coronary angiographic characteristics in Japanese patients with heterozygous familial hypercholesterolemia. Atherosclerosis 66 (1987) 29-36
42. Sudhir K., Ports T.A., Amidon T.M., et al. Increased prevalence of coronary ectasia in heterozygous familial hypercholesterolemia. Circulation 91 (1995) 1375-1380
43. Thompson G.R., Myant N.B., Kilpatrick D., Oakley C.M., Raphael M.J., and Steiner R.E. Assessment of long-term plasma exchange for familial hypercholesterolaemia. Br Heart J 43 (1980) 680-688
44. Camejo G. The interaction of lipids and lipoproteins with the intercellular matrix of arterial tissue: its possible role in atherogenesis. Adv Lipid Res 19 (1982) 1-53
45. Galis Z.S., Sukhova G.K., Kranzhofer R., Clark S., and Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A 92 (1995) 402-406
46. Huang Y., Mironova M., and Lopes-Virella M.F. Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells. Arterioscler Thromb Vasc Biol 19 (1999) 2640-2647
47. Turhan H., Erbay A.R., Yasar A.S., et al. Plasma soluble adhesion molecules; intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin levels in patients with isolated coronary artery ectasia. Coron Artery Dis 16 (2005) 45-50
48. Yilmaz H., Tayyareci G., Sayar N., et al. Plasma soluble adhesion molecule levels in coronary artery ectasia. Cardiology 105 (2006) 176-181
49. Turhan H., Erbay A.R., Yasar A.S., Balci M., Bicer A., and Yetkin E. Comparison of C-reactive protein levels in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Am J Cardiol 94 (2004) 1303-1306
50. Savino M., Parisi Q., Biondi-Zoccai G.G., Pristipino C., Cianflone D., and Crea F. New insights into molecular mechanisms of diffuse coronary ectasiae: a possible role for VEGF. Int J Cardiol 106 (2006) 307-312
51. Unemori E.N., Ferrara N., Bauer E.A., and Amento E.P. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153 (1992) 557-562
52. Dwyer J.H., Allayee H., Dwyer K.M., et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 350 (2004) 29-37
53. Zhao L., Moos M.P., Grabner R., et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 10 (2004) 966-973
54. Cipollone F., Mezzetti A., Fazia M.L., et al. Association between 5-lipoxygenase expression and plaque instability in humans. Arterioscler Thromb Vasc Biol 25 (2005) 1665-1670
55. Adiloglu A.K., Can R., Nazli C., et al. Ectasia and severe atherosclerosis: relationships with Chlamydia pneumoniae, helicobacterpylori, and inflammatory markers. Tex Heart Inst J 32 (2005) 21-27
56. Arno G., Kaski J.C., Smith D.A., Akiyu J.P., Hughes S.E., and Baboonian C. Matrix metalloproteinase-9 expression is associated with the presence of Chlamydia pneumoniae in human coronary atherosclerotic plaques. Heart 91 (2005) 521-525
57. Kol A., Sukhova G.K., Lichtman A.H., and Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98 (1998) 300-307
58. Singh B.M., and Mehta J.L. Interactions between the renin-angiotensin system and dyslipidemia: relevance in the therapy of hypertension and coronary heart disease. Arch Intern Med 163 (2003) 1296-1304
59. Uyarel H., Okmen E., Tartan Z., et al. The role of angiotensin converting enzyme genotype in coronary artery ectasia. Int Heart J 46 (2005) 89-96
60. Schieffer B., Schieffer E., Hilfiker-Kleiner D., et al. Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability. Circulation 101 (2000) 1372-1378
61. Turhan H., Erbay A.R., Yasar A.S., et al. Plasma homocysteine levels in patients with isolated coronary artery ectasia. Int J Cardiol 104 (2005) 158-162
62. Kosar F., Sincer I., Aksoy Y., and Ozerol I. Elevated plasma homocysteine levels in patients with isolated coronary artery ectasia. Coron Artery Dis 17 (2006) 23-27
63. Bescond A.B., Augier T., Chareyre C., Charpiot P., and Garçon D. Homocysteine-induced elastolysis in arterial media: activation of MMP2. Neth J Med 58 (1998) S56-S57
64. Murase Y., Yagi K., Kobayashi J., et al. Association of coronary artery ectasia with plasma insulin levels in Japanese men of heterozygous familial hypercholesterolemia with the low-density lipoprotein receptor gene mutation K790X. Clin Chim Acta 355 (2005) 33-39
65. Anderson P.W., Zhang X.Y., Tian J., et al. Insulin and angiotensin II are additive in stimulating TGF-beta 1 and matrix mRNAs in mesangial cells. Kidney Int 50 (1996) 745-753
66. Sorrell V., Davis M., and Bove A. Origins of coronary artery ectasia. The Lancet 347 (1996) 136-137
67. Johanning J.M., Franklin D.P., Han D.C., Carey D.J., and Elmore J.R. Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion. J Vasc Surg 33 (2001) 579-586
68. Johanning J.M., Armstrong P.J., Franklin D.P., Han D.C., Carey D.J., and Elmore J.R. Nitric oxide in experimental aneurysm formation: early events and consequences of nitric oxide inhibition. Ann Vasc Surg 16 (2002) 65-72
69. Paik D.C., Ramey W.G., Dillon J., and Tilson M.D. The nitrite/elastin reaction: implications for in vivo degenerative effects. Connect Tissue Res 36 (1997) 241-251
70. Rajagopalan S., Meng X.P., Ramasamy S., Harrison D.G., and Galis Z.S. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98 (1996) 2572-2579
71. Giannoglou G.D., Soulis J.V., Farmakis T.M., Farmakis D.M., and Louridas G.E. Haemodynamic factors and the important role of local low static pressure in coronary wall thickening. Int J Cardiol 86 (2002) 27-40
72. Saotome M., Satoh H., Uehara A., Katoh H., Terada H., and Hayashi H. Coronary ectasia with slow flow related to apical hypertrophic cardiomyopathy-a case report. Angiology 56 (2005) 103-106
73. Chatzizisis YS, Giannoglou GD. Myocardial bridges spare atherosclerosis: overview of the pathogenetic mechanisms. Can J Cardiol In press.
74. Porcalla A.R., Sable C.A., Patel K.M., Martin G.R., and Singh N. The epidemiology of Kawasaki disease in an urban hospital: does African American race protect against coronary artery aneurysms?. Pediatr Cardiol 26 (2005) 775-781
75. Androulakis A.E., Katsaros A.A., Kartalis A.N., et al. Varicose veins are common in patients with coronary artery ectasia. Just a coincidence or a systemic deficit of the vascular wall?. Eur J Vasc Endovasc Surg 27 (2004) 519-524
76. Yetkin E., Kilic S., Acikgoz N., et al. Increased prevalence of varicocele in patients with coronary artery ectasia. Coron Artery Dis 16 (2005) 261-264
77. Ohno T., Igarashi H., Inoue K., Akazawa K., Joho K., and Hara T. Serum vascular endothelial growth factor: a new predictive indicator for the occurrence of coronary artery lesions in Kawasaki disease. Eur J Pediatr 159 (2000) 424-429
78. Senzaki H., Masutani S., Kobayashi J., et al. Circulating matrix metalloproteinases and their inhibitors in patients with Kawasaki disease. Circulation 104 (2001) 860-863
79. Adewuya O., Irie Y., Bian K., Onigu-Otite E., and Murad F. Mechanism of vasculitis and aneurysms in Kawasaki disease: role of nitric oxide. Nitric Oxide 8 (2003) 15-25