Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization

Journal of Allergy and Clinical Immunology

Volumn 122, Issue 5, 2008, Pages

  Leggat, Jamie A ^a   Gibbons, Deena L ^b   Haque, Syeda F Y ^b   Smith, Adrian L ^c   Wells, James W ^a   Choy, Katherine ^d   Lloyd, Clare M ^d   Hayday, Adrian C ^b   Noble, Alistair ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

allergy; CD8 T cell; dendritic cell; IL 12; immunologic memory; innate immunity; TH1 TH2

Indexed keywords

ANTIGEN; CD8 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN E; INTERLEUKIN 12; TOLL LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN FUNCTION; ARTICLE; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; DENDRITIC CELL; IN VIVO STUDY; INFECTION; INNATE IMMUNITY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; TH1 CELL;

EID: 55549125530     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.08.011     Document Type: Article

References (28)

1. + T cells. Nat Immunol 3 (2002) 549-557
2. van der Pouw Kraan T.C., Boeije L.C., de Groot E.R., Stapel S.O., Snijders A., Kapsenberg M.L., et al. Reduced production of IL-12 and IL-12-dependent IFN-γ release in patients with allergic asthma. J Immunol 158 (1997) 5560-5565
3. Constant S.L., Lee K.S., and Bottomly K. Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation. Eur J Immunol 30 (2000) 840-847
4. Strachan D.P. Hay fever, hygiene, and household size. BMJ 299 (1989) 1259-1260
5. Upham J.W., and Holt P.G. Environment and development of atopy. Curr Opin Allergy Clin Immunol 5 (2005) 167-172
6. + T cells in the development of T helper type 1 responses. J Exp Med 195 (2002) 473-483
7. + T cells contributes to the rapid production of IFN-γ in response to bacterial pathogens. J Immunol 166 (2001) 1097-1105
8. + long-lived memory T cells in an allergy model. J Allergy Clin Immunol 121 (2008) 992-999
9. Smitt J.J., Boon L., and Lukacs N.W. Respiratory virus-induced regulation of asthma-like responses in mice depends upon CD8 T cells and interferon-γ production. Am J Pathol 171 (2007) 1944-1951
10. + immunoregulatory cells in the graft-versus-host reaction: CD8 T cells activate dendritic cells to secrete interleukin-12/interleukin-18 and induce T helper 1 autoantibody. Immunology 109 (2003) 476-486
11. + regulatory T cells is interleukin 10 dependent. J Exp Med 202 (2005) 1539-1547
12. van Rijt L.S., Kuipers H., Vos N., Hijdra D., Hoogsteden H.C., and Lambrecht B.N. A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma. J Immunol Methods 288 (2004) 111-121
13. + T cell turnover in vivo by IL-12, IL-18, and IFN-γ. J Immunol 166 (2001) 6007-6011
14. Murali-Krishna K., Lau L.L., Sambhara S., Lemonnier F., Altman J., and Ahmed R. Persistence of memory CD8 T cells in MHC class I-deficient mice. Science 286 (1999) 1377-1381
15. Kieper W.C., Prlic M., Schmidt C.S., Mescher M.F., and Jameson S.C. IL-12 enhances CD8 T cell homeostatic expansion. J Immunol 166 (2001) 5515-5521
16. +NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction. Clin Exp Med 7 (2007) 30-38
17. + T cells provide an early source of IFN-γ. J Immunol 170 (2003) 2399-2408
18. + T cell survival. J Immunol 172 (2004) 6065-6073
19. + T cells: evidence for two distinct pathways for promoter activation. Eur J Immunol 29 (1999) 548-555
20. + T-cell memory. Nat Med 7 (2001) 913-919
21. + T cells. Immunology 78 (1993) 226-236
22. Thorpe S.C., Kemeny D.M., Panzani R., and Lessof M.H. Allergy to castor bean, I: its relationship to sensitization to common inhalant allergens (atopy). J Allergy Clin Immunol 82 (1988) 62-66
23. Suntharalingam G., Perry M.R., Ward S., Brett S.J., Castello-Cortes A., Brunner M.D., et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 355 (2006) 1018-1028
24. + T cells. Proc Natl Acad Sci U S A 101 (2004) 6116-6121
25. Ishimitsu R., Nishimura H., Yajima T., Watase T., Kawauchi H., and Yoshikai Y. Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma. J Immunol 166 (2001) 1991-2001
26. + T cells in the lung airways depends on proliferation. J Immunol 169 (2002) 4976-4981
27. Wells J.W., Cowled C.J., Giorgini A., Kemeny D.M., and Noble A. Regulation of allergic airway inflammation by class I-restricted allergen presentation and CD8 T-cell infiltration. J Allergy Clin Immunol 119 (2007) 226-234
28. Wilson M.S., Taylor M.D., Balic A., Finney C.A., Lamb J.R., and Maizels R.M. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med 202 (2005) 1199-1212