A potential thrombus diagnosis reagent based on P-selectin monoclonal antibody SZ-51 light chain

Thrombosis Research

Volumn 123, Issue 2, 2008, Pages 306-315

  Xu, Yuanping ^a   Li, Jie ^a   Fang, Wei ^b   Yu, Meimin ^a   Ru, Binggen ^a  

^a PEKING UNIVERSITY   (China)

^b FUWAI HOSPITAL   (China)

Author keywords

Antibody; Diagnosis; Dog venous thrombus model; P selectin; SZ 51; Yeast

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY SZ 51; NUCLEOTIDE; PADGEM PROTEIN; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COLUMN CHROMATOGRAPHY; DOG; DRUG CLEARANCE; DRUG DISTRIBUTION; IN VITRO STUDY; LIGHT CHAIN; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THROMBUS;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOPHYSICAL PROCESSES; BLOOD PLATELETS; DOGS; GENETIC VECTORS; HUMANS; INDICATORS AND REAGENTS; MALE; P-SELECTIN; PICHIA; RABBITS; RADIOPHARMACEUTICALS; RECOMBINANT PROTEINS; TECHNETIUM TC 99M MERTIATIDE; THROMBOSIS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 55549111581     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.06.002     Document Type: Article

References (21)

1. Gawaz M., Langer H., and May A.E. Platelets in inflammation and atherogenesis. J Clin Invest 115 12 (2005) 3378-3384
2. Ruggeri Z.M. Platelets in atherothrombosis. Nat Med 8 11 (2002) 1227-1234
3. Schafer A., and Bauersachs J. Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis. Curr Vasc Pharmacol 6 1 (2008) 52-60
4. Baruch D. Platelet-vessel wall interactions. Therapie 61 5 (2006) 371-378
5. Chignier E., Parise M., McGregor L., Delabre C., Faucompret S., and McGregor J. A P-selectin/CD62P monoclonal antibody (LYP-20), in tandem with flow cytometry, detects in vivo activated circulating rat platelets in severe vascular trauma. Thromb Haemost 72 5 (1994) 745-749
6. Blann A.D., Nadar S.K., and Lip G.Y. The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J 24 24 (2003) 2166-2179
7. Keating F.K., Dauerman H.L., Whitaker D.A., Sobel B.E., and Schneider D.J. Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin. Thromb Res 118 3 (2006) 361-369
8. Theoret J.F., Chahrour W., Yacoub D., and Merhi Y. Recombinant P-selectin glycoprotein-ligand-1 delays thrombin-induced platelet aggregation: a new role for P-selectin in early aggregation. Br J Pharmacol 148 3 (2006) 299-305
9. Liu Z.H., Wan H.Y., Wang B., Li P.X., Ru B.G., Hu M.H., et al. Construction and Expression of a Recombinant Antibody-targeted Plasminogen Activator Composed of a Humanized Monoclonal Antibody against Activated Human Platelets and a Single-chain Urokinase. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 30 6 (1998) 601-606
10. Gu J., Liu Y., Xia L., Wan H., Li P., Zhang X., et al. Construction and expression of mouse-human chimeric antibody SZ-51 specific for activated platelet P-selectin. Thromb Haemost 77 4 (1997) 755-759
11. Wan H., Liu Z., Xia X., Gu J., Wang B., Liu X., et al. A recombinant antibody-targeted plasminogen activator with high affinity for activated platelets increases thrombolytic potency in vitro and in vivo. Thromb Res 97 3 (2000) 133-141
12. Jiang P., Changgeng R., and Ru B. Construction and expression of antibody targeted plasminogen activator*. Enzyme Microb Technol 27 10 (2000) 755-760
13. Yu M., Yu M., and Ru B. Enhanced expression of an antibody-targeted plasminogen activator in Escherichia coli by fusion to decorsin. Biotechnol Lett 26 9 (2004) 717-721
14. Kumar S., Nagl S., Kalsi J.K., Ravirajan C.T., Athwal D., Latchman D.S., et al. Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody. Mol Immunol 42 1 (2005) 39-48
15. Ledbetter J.A., Fell H.P., Grosmaire L.S., Norris N.A., and Tsu T.T. An immunoglobulin light chain dimer with CD4 antigen specificity. Mol Immunol 24 12 (1987) 1255-1261
16. Kim Y.R., Kim J.S., Lee S.H., Lee W.R., Sohn J.N., Chung Y.C., et al. Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity. J Biol Chem 281 22 (2006) 15287-15295
17. Sambrook J., Fritsch E.F., and Maniatis T.A. Molecular cloning: a laboratory manual (1989)
18. Kushimoto S., Okajima K., Uchiba M., Murakami K., Okabe H., and Takatsuki K. Pulmonary vascular injury induced by hemorrhagic shock is mediated by P-selectin in rats. Thromb Res 82 1 (1996) 97-106
19. Murphy J.F., and McGregor J.L. A peptide (P2) derived from the variable heavy chain of an anti-P-selectin monoclonal antibody (LYP20) inhibits leucocyte adhesion to thrombin-activated platelets and endothelial cells. Br J Haematol 120 4 (2003) 605-610
20. Gamble J.R., Skinner M.P., Berndt M.C., and Vadas M.A. Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140. Science (New York, NY) 249 4967 (1990) 414-417
21. Merten M., and Thiagarajan P. P-selectin expression on platelets determines size and stability of platelet aggregates. Circulation 102 16 (2000) 1931-1936