메뉴 건너뛰기




Volumn 4, Issue 1, 2007, Pages 7-14

thrombolytics a field in development

Author keywords

[No Author keywords available]

Indexed keywords

ALFIMEPRASE; ALTEPLASE; ANCROD; DESMOTEPLASE; HEPARIN; LANOTEPLASE; MICROPLASMIN; PAMITEPLASE; PLACEBO; PROUROKINASE; RETEPLASE; SARUPLASE; STAPHYLOKINASE; STREPTOKINASE; TENECTEPLASE; UNCLASSIFIED DRUG; UROKINASE;

EID: 55549106465     PISSN: 00356336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (50)
  • 1
    • 0036369437 scopus 로고    scopus 로고
    • Vascular-platelet and plasma hemostasis regulators from bloodsucking animals
    • Basanova AV, Baskova IP, Zavalova LL. Vascular-platelet and plasma hemostasis regulators from bloodsucking animals. Biochemistry (Moscow), 67:143-150 (2002)
    • (2002) Biochemistry (Moscow) , vol.67 , pp. 143-150
    • Basanova, A.V.1    Baskova, I.P.2    Zavalova, L.L.3
  • 2
    • 85007755756 scopus 로고    scopus 로고
    • ABC of antithrombotic therapy. An overview of antithrombotic therapy
    • Blann AD, Landray MJ, Lip GYH. ABC of antithrombotic therapy. An overview of antithrombotic therapy. BMJ 325: 762-765 (2002)
    • (2002) BMJ , vol.325 , pp. 762-765
    • Blann, A.D.1    Landray, M.J.2    Lip, G.Y.H.3
  • 3
    • 55549120986 scopus 로고
    • Vampires: The real story
    • Beiwood J, Morton PA. Vampires: The real story. Bats 9: 11-16 (1991)
    • (1991) Bats , vol.9 , pp. 11-16
    • Beiwood, J.1    Morton, P.A.2
  • 5
    • 0003443998 scopus 로고    scopus 로고
    • accessed October 31, 2006
    • Boehringer Ingelheim. Metalyse. Summary of product characteristics. (2004) http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid= 5532 (accessed October 31, 2006).
    • (2004) Summary of product characteristics
    • Ingelheim, B.1    Metalyse2
  • 6
    • 33750014056 scopus 로고    scopus 로고
    • accessed November 16, 2006
    • Boehringer Ingelheim. Metalyse. Scientific Discussion. (2005) http://www.emea.eu.int/humandocs/Humans/EPAR/metalyse/metalyse.htm (accessed November 16, 2006)
    • (2005) Scientific Discussion
    • Ingelheim, B.1    Metalyse2
  • 9
    • 0029915080 scopus 로고    scopus 로고
    • Fibrin-selective thrombolytic therapy for acute myocardial infarction
    • Collen D. Fibrin-selective thrombolytic therapy for acute myocardial infarction. Circulation 93: 857-865 (1996)
    • (1996) Circulation , vol.93 , pp. 857-865
    • Collen, D.1
  • 10
    • 33646765794 scopus 로고    scopus 로고
    • Non-clinical and clinical characterization of a novel acting thrombolytic: Alfimeprase
    • Deitcher SR, Toombs CF. Non-clinical and clinical characterization of a novel acting thrombolytic: alfimeprase. Pathophysiol Haemost Thromb 34:215-220 (2005)
    • (2005) Pathophysiol Haemost Thromb , vol.34 , pp. 215-220
    • Deitcher, S.R.1    Toombs, C.F.2
  • 11
    • 0031813131 scopus 로고    scopus 로고
    • Ischaemic damage of brain microvessels: Inherent risks for thrombolytic treatment in stroke
    • del Zoppo, GD, von Kummer, R, Hamann, G. Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J. Neurol. Neurosurg. Psychiatry 65:1-9 (1998)
    • (1998) J. Neurol. Neurosurg. Psychiatry , vol.65 , pp. 1-9
    • del Zoppo, G.D.1    von Kummer, R.2    Hamann, G.3
  • 12
    • 13244278111 scopus 로고    scopus 로고
    • Stimulation of Plasminogen Activation by Recombinant Prion Protein is Specific for Tissue-type Plasminogen Activator
    • Epple G, Kettelgerdes G, Köttgen E, Geßner R, Schleuning W-D, Praus M. Stimulation of Plasminogen Activation by Recombinant Prion Protein is Specific for Tissue-type Plasminogen Activator. J Thromb Haemost 2: 962-968 (2004)
    • (2004) J Thromb Haemost , vol.2 , pp. 962-968
    • Epple, G.1    Kettelgerdes, G.2    Köttgen, E.3    Geßner, R.4    Schleuning, W.-D.5    Praus, M.6
  • 14
    • 33646705400 scopus 로고    scopus 로고
    • DEDAS Investigators. Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): Evidence of safety and efficacy 3 to 9 hours after stroke onset
    • Furlan AJ, Eyding D, Albers GW, Al-Rawi Y, Lees KR, Rowley HA, Sachara C, Soehngen M, Warach S, Hacke W, DEDAS Investigators. Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): Evidence of safety and efficacy 3 to 9 hours after stroke onset Stroke 37: 1227-1231 (2006)
    • (2006) Stroke , vol.37 , pp. 1227-1231
    • Furlan, A.J.1    Eyding, D.2    Albers, G.W.3    Al-Rawi, Y.4    Lees, K.R.5    Rowley, H.A.6    Sachara, C.7    Soehngen, M.8    Warach, S.9    Hacke, W.10
  • 16
    • 0034916528 scopus 로고    scopus 로고
    • Thrombolysis in pulmonary embolism: A debatable indication
    • Goldhaber SZ. Thrombolysis in pulmonary embolism: A debatable indication. Thromb Haemost 86: 444-451 (2001)
    • (2001) Thromb Haemost , vol.86 , pp. 444-451
    • Goldhaber, S.Z.1
  • 17
    • 0030879325 scopus 로고    scopus 로고
    • A comparison of reteplase with alteplase for acute myocardial infarction. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO III) Investigators
    • GUSTO III Investigators
    • GUSTO III Investigators. A comparison of reteplase with alteplase for acute myocardial infarction. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO III) Investigators. N Engl J Med 337:1118-1123 (1997)
    • (1997) N Engl J Med , vol.337 , pp. 1118-1123
  • 18
    • 19944426190 scopus 로고    scopus 로고
    • The desmoteplase in acute ischemic stroke trial (DIAS). A phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    • for The DIAS Study Group
    • Hacke W, Albers G, Al-Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, Fischer M, Furlan, A, Kaste M, Lees KR, Soehngen M, Warach S for The DIAS Study Group. The desmoteplase in acute ischemic stroke trial (DIAS). A phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 36: 66-73 (2005)
    • (2005) Stroke , vol.36 , pp. 66-73
    • Hacke, W.1    Albers, G.2    Al-Rawi, Y.3    Bogousslavsky, J.4    Davalos, A.5    Eliasziw, M.6    Fischer, M.7    Furlan, A.8    Kaste, M.9    Lees, K.R.10    Soehngen, M.11    Warach, S.12
  • 19
    • 14844300868 scopus 로고    scopus 로고
    • A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke
    • and the TNK in Stroke Investigators
    • Haley EC Jr, Lyden PD, Johnston KC, Hemmen TM, and the TNK in Stroke Investigators. A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke. Stroke 36: 607-612 (2005)
    • (2005) Stroke , vol.36 , pp. 607-612
    • Haley Jr, E.C.1    Lyden, P.D.2    Johnston, K.C.3    Hemmen, T.M.4
  • 20
    • 33751266740 scopus 로고    scopus 로고
    • ESTAT investigators. Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: A randomised controlled trial
    • Hennerici MG, Kay R, Bogousslavsky J, Lenzi GL, Verstraete M, Orgogozo JM, ESTAT investigators. Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial. Lancet 25 368:1871-1878 (2006)
    • (2006) Lancet , vol.25 , Issue.368 , pp. 1871-1878
    • Hennerici, M.G.1    Kay, R.2    Bogousslavsky, J.3    Lenzi, G.L.4    Verstraete, M.5    Orgogozo, J.M.6
  • 22
    • 0023805341 scopus 로고    scopus 로고
    • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 332: 349-360 (1988)
    • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 332: 349-360 (1988)
  • 24
    • 4544219792 scopus 로고    scopus 로고
    • A comparative study of amyloid-beta (1-42) as a cofactor for plasminogen activation by vampire bat plasminogen activator and recombinant human tissue-type plasminogen activator
    • Kruithoff EK, Schleuning W-D. A comparative study of amyloid-beta (1-42) as a cofactor for plasminogen activation by vampire bat plasminogen activator and recombinant human tissue-type plasminogen activator. Thromb Haemost 92: 559-567 (2004)
    • (2004) Thromb Haemost , vol.92 , pp. 559-567
    • Kruithoff, E.K.1    Schleuning, W.-D.2
  • 25
    • 0036054502 scopus 로고    scopus 로고
    • Local intraarterial urokinase thrombolysis of acute ischemic stroke with or without intravenous abciximab: A pilot study
    • Lee DH, Jo KD, Kim HG, Choi S-J, Jung SM, Ryu DS, Park MS. Local intraarterial urokinase thrombolysis of acute ischemic stroke with or without intravenous abciximab: a pilot study. J Vasc Interv Radiol 13: 769-773 (2002)
    • (2002) J Vasc Interv Radiol , vol.13 , pp. 769-773
    • Lee, D.H.1    Jo, K.D.2    Kim, H.G.3    Choi, S.-J.4    Jung, S.M.5    Ryu, D.S.6    Park, M.S.7
  • 26
    • 0037321482 scopus 로고    scopus 로고
    • Vampire bat salivary plasminogen activator (Desmoteplase), a unique fibrinolytic enzyme that does not promote neurodegeneration
    • Liberatore GT, Samson A, Bladin C, Schleuning W-D, Medcalf RL. Vampire bat salivary plasminogen activator (Desmoteplase), a unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke 34: 537-543 (2003)
    • (2003) Stroke , vol.34 , pp. 537-543
    • Liberatore, G.T.1    Samson, A.2    Bladin, C.3    Schleuning, W.-D.4    Medcalf, R.L.5
  • 28
    • 20444407317 scopus 로고    scopus 로고
    • Understanding the enzymology of fibrinolysis and improving thrombolytic therapy
    • Longstaff C, Thelwell C. Understanding the enzymology of fibrinolysis and improving thrombolytic therapy. FEBS Lett 579:3303-3309 (2005)
    • (2005) FEBS Lett , vol.579 , pp. 3303-3309
    • Longstaff, C.1    Thelwell, C.2
  • 29
    • 55549138150 scopus 로고    scopus 로고
    • López-Atalaya JP, Roussel BD, Levrat D, Nicole O, Benchenane K, Castel H, Leprince J, Hommet Y, To Van D, Sopkova-de Oliveira Santos J, Bureau R1 Rault S, Vaudry H, Petersen K-U, Ali C, Vivien D. Molecular requirements for modulation of NMDA receptor signaling by tissue-type plasminogen activator. Proceedings of the 18th International Congress on Fibrinolysis and Proteolysis (ICFP): Proteolysis in the Postgenomic Era held in San Diego, California, USA, August 27-31 (2006)
    • López-Atalaya JP, Roussel BD, Levrat D, Nicole O, Benchenane K, Castel H, Leprince J, Hommet Y, To Van D, Sopkova-de Oliveira Santos J, Bureau R1 Rault S, Vaudry H, Petersen K-U, Ali C, Vivien D. Molecular requirements for modulation of NMDA receptor signaling by tissue-type plasminogen activator. Proceedings of the 18th International Congress on Fibrinolysis and Proteolysis (ICFP): Proteolysis in the Postgenomic Era held in San Diego, California, USA, August 27-31 (2006)
  • 30
    • 26444510219 scopus 로고    scopus 로고
    • Extending reperfusion therapy for acute ischemic stroke: Emerging pharmacological, mechanical, and imaging strategies
    • Molina CA, Saver JL. Extending reperfusion therapy for acute ischemic stroke: emerging pharmacological, mechanical, and imaging strategies. Stroke 36: 2311-2320 (2005)
    • (2005) Stroke , vol.36 , pp. 2311-2320
    • Molina, C.A.1    Saver, J.L.2
  • 31
    • 0000945065 scopus 로고    scopus 로고
    • Thrombolytic therapy with streptokinase in acute ischemic stroke
    • Multicenter Acute Stroke Trial-Europe Study Group
    • Multicenter Acute Stroke Trial-Europe Study Group. Thrombolytic therapy with streptokinase in acute ischemic stroke. N Engl J Med 335:145-150 (1996)
    • (1996) N Engl J Med , vol.335 , pp. 145-150
  • 34
    • 0142209155 scopus 로고    scopus 로고
    • Thrombolysis: Newer thrombolytic agents and their role in clinical medicine
    • Nordt TK, Bode C. Thrombolysis: Newer thrombolytic agents and their role in clinical medicine. Heart 89:1358-1362 (2003)
    • (2003) Heart , vol.89 , pp. 1358-1362
    • Nordt, T.K.1    Bode, C.2
  • 35
    • 0036995282 scopus 로고    scopus 로고
    • Safety and efficacy of the various thrombolytic agents
    • Ouriel K. Safety and efficacy of the various thrombolytic agents. Rev Cardiovasc Med 3 (suppl 2): S17-S24 (2002)
    • (2002) Rev Cardiovasc Med , vol.3 , Issue.SUPPL. 2
    • Ouriel, K.1
  • 36
    • 1542313878 scopus 로고    scopus 로고
    • Reteplase monotherapy and reteplase/abciximab combination therapy in peripheral arterial occlusive disease: Results from the RELAX trial
    • Ouriel K, Castaneda F, McNamara T, Swischuk J, Tepe G, Smith JJ, Clark J, Duda S. Reteplase monotherapy and reteplase/abciximab combination therapy in peripheral arterial occlusive disease: results from the RELAX trial. J Vasc Interv Radiol 15: 229-238 (2004)
    • (2004) J Vasc Interv Radiol , vol.15 , pp. 229-238
    • Ouriel, K.1    Castaneda, F.2    McNamara, T.3    Swischuk, J.4    Tepe, G.5    Smith, J.J.6    Clark, J.7    Duda, S.8
  • 37
    • 18744391049 scopus 로고    scopus 로고
    • MRI predicts area of increased plasminogen activation in permanent focal cerebral ischemia
    • Pfefferkorn T, Wiessner C, Allegrini PR, Kloss CUA, Hamann GF. MRI predicts area of increased plasminogen activation in permanent focal cerebral ischemia. Neurol Res 24: 822-824 (2002)
    • (2002) Neurol Res , vol.24 , pp. 822-824
    • Pfefferkorn, T.1    Wiessner, C.2    Allegrini, P.R.3    Kloss, C.U.A.4    Hamann, G.F.5
  • 38
    • 55549083629 scopus 로고    scopus 로고
    • A new hope for stroke? Evidence for the use of rDSPAá1 (desmoteplase) in acute ischemic stroke
    • in press
    • Pugsley MK, Lipka L, Petersen K-U, Soehngen M. A new hope for stroke? Evidence for the use of rDSPAá1 (desmoteplase) in acute ischemic stroke. Proc West Pharmacol Soc (in press)
    • Proc West Pharmacol Soc
    • Pugsley, M.K.1    Lipka, L.2    Petersen, K.-U.3    Soehngen, M.4
  • 40
    • 0036093484 scopus 로고    scopus 로고
    • Thrombolytic therapy within 3 to 6 hours after onset of ischemic stroke: Useful or harmful?
    • Ringleb PA, Schellinger PD, Schranz C, Hacke W. Thrombolytic therapy within 3 to 6 hours after onset of ischemic stroke: useful or harmful? Stroke 33: 1437-1441 (2002)
    • (2002) Stroke , vol.33 , pp. 1437-1441
    • Ringleb, P.A.1    Schellinger, P.D.2    Schranz, C.3    Hacke, W.4
  • 41
    • 0035742590 scopus 로고    scopus 로고
    • Vampire bat plasminogen activator DSPA-alpha-1 (desmoteplase): A thrombolytic drug optimized by natural selection
    • Schleuning W-D. Vampire bat plasminogen activator DSPA-alpha-1 (desmoteplase): A thrombolytic drug optimized by natural selection. Haemostasis 31: 118-122 (2001)
    • (2001) Haemostasis , vol.31 , pp. 118-122
    • Schleuning, W.-D.1
  • 43
    • 0032540925 scopus 로고    scopus 로고
    • Characterization of the interactions of plasminogen and tissue and vampire bat plasminogen activators with fibrinogen, fibrin, and the complex of D-dimer concovalently linked to fragment E
    • Stewart RJ, Fredenburgh JC, Weitz JI. Characterization of the interactions of plasminogen and tissue and vampire bat plasminogen activators with fibrinogen, fibrin, and the complex of D-dimer concovalently linked to fragment E. J Biol Chem 273: 18292-18299 (1998)
    • (1998) J Biol Chem , vol.273 , pp. 18292-18299
    • Stewart, R.J.1    Fredenburgh, J.C.2    Weitz, J.I.3
  • 44
    • 0036195260 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats
    • Sumii T, Lo EH, Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke 33: 831-836 (2002)
    • (2002) Stroke , vol.33 , pp. 831-836
    • Sumii, T.1    Lo, E.H.2
  • 45
    • 13244271945 scopus 로고    scopus 로고
    • Comparative effects of microplasmin and tissue-type plasminogen activator (tPA) on cerebral hemorrhage in a middle cerebral artery occlusion model in mice. J
    • Suzuki Y, Nagai N, Collen D. Comparative effects of microplasmin and tissue-type plasminogen activator (tPA) on cerebral hemorrhage in a middle cerebral artery occlusion model in mice. J J Thromb Haemost, 2: 1617-1621 (2004)
    • (2004) J Thromb Haemost , vol.2 , pp. 1617-1621
    • Suzuki, Y.1    Nagai, N.2    Collen, D.3
  • 49
    • 3242688902 scopus 로고    scopus 로고
    • Tissue-type plasminogen ayctivator and neuroserpin: A well-balanced act in the nervous system?
    • Yepes M, Lawrence DA. Tissue-type plasminogen ayctivator and neuroserpin: A well-balanced act in the nervous system? Cardiovasc Med 14:173-180 (2004)
    • (2004) Cardiovasc Med , vol.14 , pp. 173-180
    • Yepes, M.1    Lawrence, D.A.2
  • 50
    • 0345824713 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein
    • Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest 112: 1533-1540 (2003).
    • (2003) J Clin Invest , vol.112 , pp. 1533-1540
    • Yepes, M.1    Sandkvist, M.2    Moore, E.G.3    Bugge, T.H.4    Strickland, D.K.5    Lawrence, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.