Reteplase Monotherapy and Reteplase/Abciximab Combination Therapy in Peripheral Arterial Occlusive Disease: Results from the RELAX Trial

Journal of Vascular and Interventional Radiology

Volumn 15, Issue 3, 2004, Pages 229-238

  Ouriel, Kenneth ^a   Castaneda, Flavio ^b   McNamara, Thomas ^c   Swischuk, James ^b   Tepe, Gunnar ^e   Smith, John J ^d   Clark, Jason ^d   Duda, Stephan ^e  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CENTOCOR INC   (United States)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; CLOPIDOGREL; HEPARIN; RETEPLASE; TICLOPIDINE;

ADULT; AGED; ANGIOGRAPHY; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CATHETER; CATHETER DIRECTED THROMBOLYSIS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INTERVENTIONAL RADIOLOGY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; OPEN STUDY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; THROMBOCYTOPENIA; THROMBUS; VASCULAR PATENCY;

EID: 1542313878     PISSN: 10510443     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.RVI.0000116193.44877.0F     Document Type: Article

References (13)

1. TransAtlantic Inter-society Consensus (TASC). Management of peripheral artery disease (PAD). J Vasc Surg 2000; 31(suppl 2):S1-S283.
2. Ouriel K, Veith F, Susahara A, for the TOPAS Investigators. A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. N Engl J Med 1998; 338:1105-1111.
3. STILE Investigators. Results of a prospective, randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity - the STILE Trial. Ann Surg 1994; 220:251-268.
4. Antman E, Gibson C, de Lemos J, et al, for the Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators. Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. Eur Heart J 2000; 21:1944-1953.
5. Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. Circulation 2000; 1010:2788-2794.
6. Rao A, Pratt C, Berke A, et al. Thrombolysis in Myocardial Infarction (TIMI) trial - phase 1: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol 1988; 11:1-11.
7. Tepe G, Schott U, Erley C, Albes J, Claussen C, Duda S. Platelet glycoprotein IIb/IIIa receptor antagonist used in conjunction with thrombolysis for peripheral arterial thrombosis. AJR Am J Roentgenol 1999; 172:1343-1346.
8. Duda S, Tepe G, Luz O, et al. Peripheral artery occlusion: treatment with abciximab plus urokinase versus with urokinase alone - a randomized pilot trial (the PROMPT study). Radiology 2001; 221:689-696.
9. Schweizer J, Kirch W, Koch R, Muller A, Hellner G, Forkmann L. Short and long-term results of abciximab versus aspirin in conjunction with thrombolysis for patients with peripheral occlusive arterial disease and arterial thrombosis. Angiology 2000; 51:913-923.
10. Haumer M, Atteneder M, Ahmadi R, Schillinger M, Minar E. Coadministration of low-dose urokinase and abciximab in thrombolysis for lower limb ischemia: a safety study. Thromb Res 2001; 103(suppl):S143-S149.
11. Ouriel K, Gray B, Clair D, Olin J. Complications associated with the use of urokinase and recombinant tissue plasminogen activator for catheter-directed peripheral arterial and venous thrombolysis. J Vasc Interv Radiol 2000; 11:295-298.
12. Korn P, Khilnani N, Fellers J, et al. Thrombolysis for native arterial occlusions of the lower extremities: clinical outcome and cost. J Vasc Surg 2001; 33:1148-1157.
13. Swischuk J, Fox P, Young K, et al. Transcatheter intraarterial infusion of rt-PA for acute lower limb ischemia: results and complications. J Vasc Interv Radiol 2001; 12:423-430.