Haemostatic effects of phytoestrogen genistein in postmenopausal women

Thrombosis Research

Volumn 123, Issue 2, 2008, Pages 231-235

  Trifiletti, A ^a   Gaudio, A ^a   Lasco, A ^a   Atteritano, M ^a   Scamardi, R ^a   Pizzoleo, M A ^a   Morabito, N ^a   Frisina, N ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Genistein; Haemostatic system; Phytoestrogens; postmenopausal women

Indexed keywords

CALCIUM; COLECALCIFEROL; D DIMER; GENISTEIN; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ABDOMINAL PAIN; ADULT; ARTICLE; BODY MASS; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEART PROTECTION; HEMOSTASIS; HUMAN; MAJOR CLINICAL STUDY; OSTEOPENIA; POSTMENOPAUSE; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION;

BONE DISEASES, METABOLIC; DOUBLE-BLIND METHOD; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; GENISTEIN; HEMOSTASIS; HUMANS; MIDDLE AGED; OUTPATIENTS; PEPTIDE FRAGMENTS; PHYTOESTROGENS; PLASMINOGEN ACTIVATOR INHIBITOR 1; POSTMENOPAUSE; PROTHROMBIN; TREATMENT OUTCOME;

EID: 55549095658     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.02.009     Document Type: Article

References (21)

1. Marrugat J., Sala J., and Aboal J. Epidemiology of cardiovascular disease in women. Rev Esp Cardiol 59 (2006) 264-274
2. Stampfer M.J., and Colditz G.A. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 20 (1991) 47-63
3. Manson J.E., Hsia J., Johnson K.C., Rossouw J.E., Assaf A.R., Lasser N.L., et al. Women's Health Initiative Investigators. Women's Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349 (2003) 523-534
4. Hulley S., Grady D., Bush T., Furberg C., Herrington D., Riggs B., et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 280 (1998) 605-613
5. Peverill R.E. Hormone therapy and venous thromboembolism. Best Pract Res Clin Endocrinol Metab 17 (2003) 149-164
6. Park D., Huang T., and Frishman W.H. Phytoestrogens as cardioprotective agents. Cardiol Rev 13 (2005) 13-17
7. Atteritano M., Marini H., Minutoli L., Polito F., Bitto A., Altavilla D., et al. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 92 (2007) 3068-3075
8. Kuiper G.G., Lemmen J.G., Carlsson B., Corton J.C., Safe S.H., van der Saag P.T., et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139 (1998) 4252-4263
9. Finking G., Hess B., and Hanke H. The value of phytoestrogens as a possible therapeutic option in postmenopausal women with coronary heart disease. J Obstet Gynaecol 19 (1999) 455-459
10. Anderson J.J.B., Anthony M.S., Messina M., and Garner S.C. Effects of phytoestrogens on tissues. Nutr Res Rev 12 (1999) 75-116
11. Lee M.Y., and Man R.Y. The phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary artery. Eur J Pharmacol 481 (2003) 227-232
12. Kondo K., Suzuki Y., Ikeda Y., and Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 455 (2002) 53-57
13. Lee C.S., Kwon S.J., Na S.Y., Lim S.P., and Lee J.H. Genistein supplementation inhibits atherosclerosis with stabilization of the lesions in hypercholesterolemic rabbits. J Korean Med Sc 19 (2004) 656-661
14. Nestel P.J., Yamashita T., Sasahara T., Pomeroy S., Dart A., Komesaroff P., et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol 17 (1997) 3392-3398
15. Nestel P.J., Pomeroy S., Kay S., Komesaroff P., Behrsing J., Cameron J.D., et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 84 (1999) 895-898
16. Teede H.J., Dalais F.S., Kotsopoulos D., McGrath B.P., Malan E., Eng Gan T., et al. Dietary soy containing phytoestrogens does not activate the hemostatic system in postmenopausal women. J Clin Endocrinol Metab 90 (2005) 1936-1941
17. Kroon U.B., Silfverstolpe G., and Tengborn L. The effects of transdermal estradiol and oral conjugated estrogens on haemostasis variables. Thromb Haemost 71 (1994) 420-423
18. Vehkavaara S., Silveira A., Hakala-Ala-Pietila T., Virkamaki A., Hovatta O., Hamsten A., et al. Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb Haemost 85 (2001) 619-625
19. Pradhan A.D., LaCroix A.Z., Langer R.D., Trevisan M., Lewis C.E., Hsia J.A., et al. Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal women. Circulation 110 (2004) 292-300
20. Koh K.K., Mincemoyer R., Bui M.N., Csako G., Pucino F., Guetta V., et al. Effects of hormone-replacement therapy on fibrinolysis in postmenopausal women. N Engl J Med 336 (1997) 683-690
21. Colacurci N., Chiàntera A., Fornaro F., de Novellis V., Manzella D., Arciello A., et al. Effects of soy isoflavones on endothelial function in healthy postmenopausal women. Menopause 12 (2005) 299-307