New cyclic somatostatin analogues containing a pyrazinone ring: Importance of Tyr for antiproliferative activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6199-6201

  Miyazaki, Anna ^a   Tsuda, Yuko ^a   Fukushima, Shoji ^a   Yokoi, Toshio ^a   Vántus, Tibor ^b   Bökönyi, Gyöngyi ^b   Szabó, Edit ^b   Horváth, Anikó ^b   Kéri, György ^b   Okada, Yoshio ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Antiproliferative activity; Pyrazinone ring; Somatostatin analogue

Indexed keywords

3 (4' AMINOBUTYL) 6 (2' CARBOXYETHYL) 5 METHYL 2(1H) PYRAZINONE; 6 (4' AMINOBUTYL) 3 (2' CARBOXYETHYL) 5 METHYL 2(1H) PYRAZINONE; CYCLOHEXIMIDE; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLLYSYLCYSTEINYLTHREONINAMIDE 2,6 DISULFIDE; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN A431; CELL STRAIN SW480; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PYRAZINES; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 55549091368     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.001     Document Type: Article

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