Differential blocking effects of the acetaldehyde-derived DNA lesion N 2-ethyl-2′-deoxyguanosine on transcription by multisubunit and single subunit RNA polymerases

Journal of Biological Chemistry

Volumn 283, Issue 41, 2008, Pages 27820-27828

  Cheng, Tsu Fan ^a   Hu, Xiaopeng ^b   Gnatt, Averell ^b   Brooks, Philip J ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; DNA; ESCHERICHIA COLI; ETHANOL; GENES; MAMMALS; NANOTECHNOLOGY; ORGANIC ACIDS; POLYMERS; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS; YEAST;

ACTIVE SITES; BLOCKING EFFECTS; DEOXYGUANOSINE; DNA LESIONS; DNA POLYMERASES; IN VITRO; LESION BYPASSES; MULTISUBUNIT; PRIMER EXTENSIONS; RNA POLYMERASES;

NUCLEIC ACIDS;

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; DEOXYGUANOSINE; DNA POLYMERASE; N2 ETHYL 2' DEOXYGUANOSINE; RNA POLYMERASE; TRANSCRIPTION ELONGATION FACTOR; TRANSCRIPTION FACTOR IIS; UNCLASSIFIED DRUG; BACTERIOPHAGE T7 RNA POLYMERASE; DNA; DNA DIRECTED RNA POLYMERASE; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; N2-ETHYL-2'-DEOXYGUANOSINE; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSCRIPTION FACTOR S II; TRANSCRIPTION FACTOR S-II; VIRUS PROTEIN;

ALCOHOL METABOLISM; ARTICLE; ASIAN; CARCINOGENICITY; DNA ADDUCT; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ESCHERICHIA COLI; ESOPHAGUS CANCER; GENETIC TRANSCRIPTION; GENOTOXICITY; HUMAN; MITOCHONDRION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; ANIMAL; BACTERIOPHAGE T7; CATTLE; CHEMISTRY; ENZYMOLOGY; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE;

ESCHERICHIA COLI; MAMMALIA;

ANIMALS; BACTERIOPHAGE T7; CATTLE; DEOXYGUANOSINE; DNA; DNA-DIRECTED RNA POLYMERASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ELONGATION FACTORS; VIRAL PROTEINS;

EID: 55549090727     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804086200     Document Type: Article

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