Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (Glial cell missing homolog 1) ubiquitination and degradation

Biology of Reproduction

Volumn 79, Issue 5, 2008, Pages 914-920

  Chiang, Meng Hsiu ^a   Chen, Liang Fu ^a   Chen, Hungwen ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

GCM1; Placenta; Pregnancy; Syncytiotrophoblast; Trophoblast; Ubiquitination

Indexed keywords

F BOX AND REPEAT DOMAIN CONTAINING 2 PROTEIN; F BOX PROTEIN; GLIAL CELL MISSING HOMOLOG 1; TRANSCRIPTION FACTOR; UBE2D2 ENZYME; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL FUSION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME REGULATION; ENZYME STABILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PLACENTA; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA INTERFERENCE; SYNCYTIOTROPHOBLAST; UBIQUITINATION;

CELL LINE; F-BOX PROTEINS; FEMALE; HUMANS; NUCLEAR PROTEINS; PLACENTA; PREGNANCY; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION FACTORS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

EID: 55549085912     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.108.071407     Document Type: Article

References (30)

1. Pickart CM. Mechanisms underlying ubiquitination. Annu Rev Biochem 2001; 70:503-533.
2. Dye BT, Schulman BA. Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins. Annu Rev Biophys Biomol Struct 2007; 36:131-150.
3. Jin J, Li X, Gygi SP, Harper JW. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Nature 2007; 447:1135-1138.
4. Schreiber J, Riethmacher-Sonnenberg E, Riethmacher D, Tuerk EE, Enderich J, Bosl MR, Wegner M. Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa. Mol Cell Biol 2000; 20:2466-2474.
5. Anson-Cartwright L, Dawson K, Holmyard D, Fisher SJ, Lazzarini RA, Cross JC. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Nat Genet 2000; 25:311-314.
6. Mi S, Lee X, Li X, Veldman GM, Finnerty H, Racie L, LaVallie E, Tang XY, Edouard P, Howes S, Keith JC Jr, McCoy JM. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 2000; 403:785-789.
7. Yu C, Shen K, Lin M, Chen P, Lin C, Chang GD, Chen H. GCMa regulates the syncytin-mediated trophoblastic fusion. J Biol Chem 2002; 277:50062-50068.
8. Chang M, Mukherjea D, Gobble RM, Groesch KA, Torry RJ, Torry DS. Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast. Biol Reprod 2008; 78:841-851.
9. Yang CS, Yu C, Chuang HC, Chang CW, Chang GD, Yao TP, Chen H. FBW2 targets GCMa to the ubiquitin-proteasome degradation system. J Biol Chem 2005; 280:10083-10090.
10. Chang CW, Chuang HC, Yu C, Yao TP, Chen H. Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. Mol Cell Biol 2005; 25:8401-8414.
11. Eyre TA, Ducluzeau F, Sneddon TP, Povey S, Bruford EA, Lush MJ. The HUGO Gene Nomenclature Database, 2006 updates. Nucleic Acids Res 2006; 34:D319-D321.
12. Cohen SX, Moulin M, Schilling O, Meyer-Klaucke W, Schreiber J, Wegner M, Muller CW. The GCM domain is a Zn-coordinating DNA-binding domain. FEBS Lett 2002; 528:95-100.
13. Cohen SX, Moulin M, Hashemolhosseini S, Kilian K, Wegner M, Muller CW. Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition. EMBO J 2003; 22:1835-1845.
14. Basyuk E, Cross JC, Corbin J, Nakayama H, Hunter P, Nait-Oumesmar B, Lazzarini RA. Murine Gcm1 gene is expressed in a subset of placental trophoblast cells. Dev Dyn 1999; 214:303-311.
15. Nait-Oumesmar B, Copperman AB, Lazzarini RA. Placental expression and chromosomal localization of the human Gcm 1 gene. J Histochem Cytochem 2000; 48:915-922.
16. Chou CC, Chang C, Liu JH, Chen LF, Hsiao CD, Chen H. Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a. J Biol Chem 2007; 282:27239-27249.
17. Zheng N, Wang P, Jeffrey PD, Pavletich NP. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 2000; 102:533-539.
18. Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, et al. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 2002; 416:703-709.
19. Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R. Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. Structure 2004; 12:633-644.
20. Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA. Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature 2007; 445:394-398.
21. Lois LM, Lima CD. Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J 2005; 24:439-451.
22. Furukawa M, Ohta T, Xiong Y. Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J Biol Chem 2002; 277:15758-15765.
23. Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A 1999; 96:11364-11369.
24. Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. J Biol Chem 1999; 274:14823-14830.
25. Rodrigo-Brenni MC, Morgan DO. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell 2007; 130:127-139.
26. Cardozo T, Pagano M. The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 2004; 5:739-751.
27. Okamoto Y, Ozaki T, Miyazaki K, Aoyama M, Miyazaki M, Nakagawara A. UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme. Cancer Res 2003; 63:4167-4173.
28. Song S, Kim SY, Hong YM, Jo DG, Lee JY, Shim SM, Chung CW, Seo SJ, Yoo YJ, Koh JY, Lee MC, Yates AJ, et al. Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity. Mol Cell 2003; 12:553-563.
29. Roest HP, van Klaveren J, de Wit J, van Gurp CG, Koken MH, Vermey M, van Roijen JH, Hoogerbrugge JW, Vreeburg JT, Baarends WM, Bootsma D, Grootegoed JA, et al. Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification. Cell 1996; 86:799-810.
30. Jentsch S, McGrath JP, Varshavsky A. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature 1987; 329:131-134.