α-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells

Phytotherapy Research

Volumn 22, Issue 10, 2008, Pages 1299-1302

  Bun, Sok Siya ^a   Elias, Riad ^a   Baghdikian, Béatrice ^a   Ciccolini, Joseph ^a   Ollivier, Evelyne ^a   Balansard, Guy ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

hederin; 5 Fluorouracil; Combination chemotherapy; Cytotoxicity; HT 29

Indexed keywords

ALPHA HEDERIN; FLUOROURACIL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HT29 CELLS; HUMANS; OLEANOLIC ACID; SAPONINS;

EID: 55449126172     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2483     Document Type: Article

References (27)

1. Amara-Mokrane YA, Lehucher-Michel MP, Balansard G, Duménil G, Botta A. 1996. Protective effects of α-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes. Mutagenesis 11: 161-167.
2. Choi J, Hu K, Kim SH, Lee KT, Lee HK, Park HJ. 2002a. Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent. J Ethnopharmacol 79: 113-118.
3. Choi J, Hu K, Kim SH, Lee KT, Park HJ, Han YN. 2002b. Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. J Ethnopharmacol 79: 199-204.
4. Chou TC, Talalay P. 1984. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55.
5. Chwalek M, Lalun N, Bobichon H, Plé K, Voutquenne-Nazabadioko L. 2006. Structure-activity relationships of some hederagenin diglycosides: haemolysis, cytotoxicity and apoptosis induction. Biochim Biophys Acta 1760: 1418-1427.
6. Cicollini J, Peillard L, Aubert C, Formento P, Milano G, Catalin J. 2000. Monitoring of the intracellular activation of 5-fluorouracil to deoxyribonucleotides in HT29 human colon cell line: application to modulation of metabolism and cytotoxicity study. Fundam Clin Pharmacol 14: 147-154.
7. Cragg GM, Newman DJ. 2005. Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79.
8. Danloy S, Quetin-Leclercq J, Coucke P et al. 1994. Effects of α-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med 60: 45-49.
9. 1, as compared to their action on mammalian cells cultured in vitro. Planta Med 66: 343-347.
10. Elias R, De Méo M, Vidal-Ollivier E, Laget M, Balansard G, Dumenil G. 1990. Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L., and Hedera helix L. Mutagenesis 5: 327-331.
11. Elias R, Diaz Lanza AM, Vidal-Ollivier E, Balansard G, Faure R, Babadjamian A. 1991a. Triterpenoid saponins from the leaves of Hedera helix. J Nat Prod 54: 98-103.
12. Elias R, Diaz Lanza AM, Vidal-Ollivier E, Maillard C, Crespin F, Balansard G. 1991b. Influence of the drying process and alcohols on the extraction of hederasaponin C and α-hederin from the leaves of Hedera helix L. J Pharm Belg 46: 177-181.
13. Gaidi G, Correia M, Chauffert B, Beltramo JL, Wagner H, Lacaille-Dubois MA. 2002. Saponins-mediated potentiation of cisplatin accumulation and cytotoxicity in human colon cancer cells. Planta Med 68: 70-72.
14. Johnston JS, Johnson A, Gan Y, Wientjes MG, Au JLS. 2003. Synergy between 3′-azido-3′-deoxythymidine and paclitaxel in human pharynx FaDu cells. Pharm Res 20: 957-961.
15. Kim YK, Kim RG, Park SJ et al. 2002. In vitro anti-inflammatory activity of kalopanaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells. Biol Pharm Bull 25: 472-476.
16. Kumara SS, Huat BT. 2001. Extraction, isolation and characterisation of antitumor principle, α-hederin, from the seeds of Nigella sativa. Planta Med 67: 29-32.
17. Lee KT, Sohn IC, Park HJ, Kim DW, Jung GO, Park KY. 2000. Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosides and bidesmosides isolated from the stem bark of Kalopanax pictus. Planta Med 66: 329-332.
18. 2 genotoxicity in HepG2 cells by alkaline comet assay. Mutat Res 445: 9-20.
19. Park HJ, Kwon SH, Lee JH, Lee KH, Miyamoto KI, Lee KT. 2001. Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides. Planta Med 67: 118-121.
20. Quetin-Leclercq J, Elias R, Balansard G, Bassleer R, Angenot L. 1992. Cytotoxic activity of some triterpenoid saponins. Planta Med 58: 279-281.
21. Reddy L, Odhav B, Bhoola KD. 2003. Natural products for cancer prevention: a global perspective. Pharmacol Ther 99: 1-13.
22. 1, in association with pentamidine and amphotericin B. Phytother Res 15: 298-301.
23. Rooney S, Ryan MF. 2005a. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res 25: 2199-2204.
24. Rooney S, Ryan MF. 2005b. Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against Hep-2 cancer cells. Anticancer Res 25: 4255-4260.
25. Swamy SMK, Huat BTK. 2003. Intracellular glutathione depletion and reactive oxygen species generation are important in α-hederin-induced apoptosis of P388 cells. Mol Cell Biochem 245: 127-139.
26. Tian Z, Liu YM, Chen SB et al. 2006. Cytotoxicity of two triterpenoids from Nigella glandulifera. Molecules 11: 693-699.
27. Trute A, Gross J, Mutschler E, Nahrstedt A. 1997. In vitro anti-spasmodic compounds of the dry extract obtained from Hedera helix. Planta Med 63: 125-129.