Immunoreactivity of Lewis blood group and mucin peptide core antigens: Correlations with grade of dysplasia and malignant transformation in the colorectal adenoma-carcinoma sequence

Histology and Histopathology

Volumn 17, Issue 1, 2002, Pages 191-198

  Baldus, Stephan E ^a   Hanisch, F G ^a   Putz C ^a   Flucke, U ^a   Monig S P ^a   Schneider, P M ^a   Thiele, J ^a   Holscher A H ^a   Dienes, H P ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Colon cancer; Immunohistology; Lewis blood group antigens; Monoclonal antibody (mab); Mucin antigens; Tumor antigens

Indexed keywords

BLOOD GROUP ANTIGEN; CARBOHYDRATE; EPITOPE; LEWIS X ANTIGEN; LEWIS Y ANTIGEN; MONOCLONAL ANTIBODY; MUCIN; MUCIN 1; MUCIN 2; MUCIN 5AC; SIALYL LEWIS A ANTIGEN; SIALYL LEWIS X ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADENOMA; ANTIBODY LABELING; ARTICLE; BLOOD GROUP LEWIS SYSTEM; CANCER CLASSIFICATION; CANCER GRADING; CANCER GROWTH; COLORECTAL CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE MARKER; DYSPLASIA; GLYCOPROTEIN SYNTHESIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALIGNANT TRANSFORMATION; MUCINOUS CARCINOMA; PROTEIN GLYCOSYLATION; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE;

ADENOMA; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CA-15-3 ANTIGEN; CARBOHYDRATES; CARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; GLYCOSYLATION; HUMANS; IMMUNOHISTOCHEMISTRY; LEWIS BLOOD-GROUP SYSTEM; MUCINS; OLIGOSACCHARIDES; PARAFFIN EMBEDDING; PEPTIDES; TISSUE FIXATION;

EID: 0036162279     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. y antigen in human immunodeficiency virus-infected human T cell lines and in peripheral lymphocytes of patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex
2. Immunohistochemical 19-9 in primary colonic polyps and polyps synchronous with colorectal cancer
3. Significance of MUC1 and MUC2 mucin expression in colorectal cancer
4. MUC1 and MUC2 mucins in flat and polypoid colorectal adenomas
5. Localization of tumor-associated glycoprotein DF3 in normal, inflammatory, and neoplastic lesions of the colon
6. Gastrointestinal cancer-associated antigen in immunoperoxidase assay
7. Biochemistry and pathological importance of mucin-associated antigens in gastrointestinal neoplasia
8. Expression of alpha-3-4-monofucosylated polylactosminoglycan epitope, as defined by monoclonal antibody FW6, is a marker of the colorectal adenoma-carcinoma sequence
9. Coexpression of MUC1 mucin peptide core and the Thomsen-Friedenreich antigen in colorectal neoplasms
10. y) antigen defined by monoclonal antibody 12-4LE in distal colonic adenocarcinomas
11. Aberrant expression of MUC5AC and MUC6 gastric mucin genes in colorectal polyps
12. Expression of MUC2-mucin in colorectal adenomas and carcinomas of different historical types
13. Immunohistochemical localization of Y hapten and the structurally related H type-2-blood-group antigen on large-bowel tumours and normal adult tissues
14. Aberrant expression of a human mucine gene (MUC5AC) in rectosigmoid villous adenoma
15. Complexity of expression of antigenic determinants, recognised by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells
16. Immunodetetion of epithelial mucin (MUC1, MUC3) and mucin-associated glycotopes (TF, Tn, and sialosyl-Tn) in benign and malignant lesions of colonic epithelium: Apolar localization corresponds to malignant transformation
17. Characterization of sialosylated Lewis x as a new tumor-associated antigen
18. Expression of carbohydrate antigen 19-9 and stage-specific embryonic antigen 1 in nontumorous and tumorous epithelia of the human colon and rectum
19. Tissue expression of the tumor associated antigen CA242 in benign and malignant pancreatic lesions. A comparison with CA50 and CA19-9
20. Sialyl Lewis(x) antigen as defined by monoclonal antibody AM-3 is a marker of dysplasia in the colonic adenoma-carcinoma sequence
21. Detection of a mucin marker for the adenoma-carcinoma sequence in human colonic mucosa by monoclonal antibody AM-3
22. Characterization of the major sialyl-Le(X)-positive mucins present in colon, colon carcinoma, and sera of patients with colorectal cancer
23. Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast and ovary
24. Heterogeneity of mucin gene expression in normal and neoplastic tissues
25. Altered mucin core peptide immunoreactivity on the colon polyp-carcinoma sequence
26. x-related antigen expression in human malignant and non-malignant colonic tissues
27. Carbohydrate antigen expression in the adenoma-carcinoma sequence
28. y blood group-related antigens in human malignant, premalignant and non-malignant colonic tissues
29. Classification of colorectal adenomas with quantitative pathology: Evaluation of morphometry, stereology, mitotic counts and syntactic structure analysis
30. Detailed phenotypic analysis of B-cell lymphoma using a panel of antibodies reactive in routinely fixed wax-embedded tissue
31. Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody
32. b, X and Y blood group antigens in human colonic tumors and normal tissues and in human tumor-derived cell lines
33. Report on the First International Workshop on carcinoma-associated mucins
34. Tissue expression of carbohydrate antigen 19-9 (CA 19-9) in adenomatous lesions of the colorectum
35. Differential expression of the Lewis Y antigen defined by monoclonal antibody C14/1/46/10 in colonic polyps
36. Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer
37. x antigens in human colorectal polyps