Expression of phospho-Elk-1 in rat gut after the whole body gamma irradiation

Physiological Research

Volumn 57, Issue 5, 2008, Pages 753-759

  Driák, Daniel ^a,b   Osterreicher J ^b   Rehakova Z ^b   Vilasova Z ^b   Vavrova J ^b  

^a UNIVERSITY HOSPITAL BULOVKA   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Biodosimetric marker; Phospho Elk 1 expression; Radiation induced entero colitis

Indexed keywords

BIOLOGICAL MARKER; ELK1 PROTEIN, RAT; TRANSCRIPTION FACTOR ELK 1;

ACUTE RADIATION SYNDROME; ANIMAL; ARTICLE; COLON; ENTEROCOLITIS; GAMMA RADIATION; JEJUNUM; MALE; METABOLISM; PHOSPHORYLATION; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; RAT; TIME; UPREGULATION; WHOLE BODY RADIATION; WISTAR RAT;

ACUTE RADIATION SYNDROME; ANIMALS; BIOLOGICAL MARKERS; COLON; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENTEROCOLITIS; ETS-DOMAIN PROTEIN ELK-1; GAMMA RAYS; JEJUNUM; MALE; PHOSPHORYLATION; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, WISTAR; TIME FACTORS; UP-REGULATION; WHOLE-BODY IRRADIATION;

EID: 55449091417     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. CAVIGELLI M, DOLFI F, CLARET FX, KARIN M: Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J 14: 5957-5964, 1995.
2. COOGAN AN, PIGGINS HD: Circadian and photic regulation of phosphorylation of ERK1/2 and Elk-1 in the suprachiasmatic nuclei of the Syrian hamster. J Neurosci 23: 3085-3093, 2003.
3. FAJARDO LF: Pathology of Radiation Injury. Masson Publishing, New York, 1982.
4. KAMINSKA B, KACZMAREK L, ZANGENEHPOUR S, CHAUDHURI A: Rapid phosphorylation of Elk-1 transcription factor and activation of MAP kinase signal transduction pathways in response to visual stimulation. Mol Cell Neurosci 13: 405-414, 1999.
5. KASZA A, O'DONNELL A, GASCOIGNE K, ZEEF LA, HAYES, A, SHARROCKS AD: The ETS domain transcription factor elk-1 regulates the expression of its partner protein, SRF. J Biol Chem 280: 1149-1155, 2005.
6. KORTENJANN M, THOMAE O, SHAW PE: Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. Mol Cell Biol 14: 4815-4824, 1994.
7. LECHNER S, MÜLLER-LADNER U, RENKE B, SCHÖLMERICH J, RÜSCHOFF J, KULLMANN F: Gene expression pattern of laser microdissected colonic crypts of adenomas with low grade dysplasia. Gut 52: 1148-1153, 2003.
8. MARAIS R, WYNNE J, TREISMAN R: The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73: 381-393, 1993.
9. MURAI K, TREISMAN R: Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1. Mol Cell Biol 22: 7083-7092, 2002.
10. NARANG H, KRISHNA M: Mitogen-activated protein kinases: specifity of response to dose of ionizing radiation in liver. J Radiat Res 45: 213-220, 2004.
11. NGUYEN NP, ANTOINE JE, DUTTA S, KARLSSON U, SALLAH, S: Current concepts in radiation enteritis and implications for future clinical trials. Cancer 95: 1151-1163, 2002.
12. ÖSTERREICHER J, VÁVROVÁ J: Lectures in Radiobiology. (in Czech) Manus, Prague, 2003.
13. ÖSTERREICHER J, DRIÁK D, VILASOVÁ Z, VÁVROVÁ J: Impact of phospho-Elk-1 expression in enterocytes in biological dosimetry after low-dose irradiation. Def Sci J 57: 845-851, 2007.
14. PRICE MA, CRUZALEGUI FH, TREISMAN R: The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light. EMBO J 15: 6552-6563, 1996.
15. SALINAS S, BRIANCON-MARJOLLET A, BOSSIS G, LOPEZ MA, PIECHACZYK M, JARIEL-ENCONTRE I, DEBANT A, HIPSKIND RA: SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. J Cell Biol 165: 767-773, 2004.
16. STULÍK J, ÖSTERREICHER J, KAFFENBERGER W, MACELA A: Radiation-induced signaling mechanisms in cells (in Czech). Voj zdrav listy 69: 263-266, 2000.
17. SUZUKI K, KODAMA S, WATANABE M: Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. Cancer Res 61: 5396-5401, 2001.
18. TORII S, KUSAKABE M, YAMAMOTO T, MAEKAWA H, NISHIDA E: Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell 7: 33-44, 2004.
19. WHITMARSH AJ, SHORE P, SHARROCKS AD, DAVIS RJ: Integration of MAP kinase signal transduction pathways at the serum response element. Science 269: 403-407, 1995.