Impact of phospho-ELK-1 expression in enterocytes in biodosimetry after low-dose irradiation

Defence Science Journal

Volumn 57, Issue 6, 2007, Pages 845-851

  Osterreicher J ^a   Driak, D ^a,b   Vilasova, Z ^a   Vavrova, J ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY HOSPITAL BULOVKA   (Czech Republic)

Author keywords

Biodosimetry; Biomarkers; Image analysis; Immunohistrochemistry; Phospho ELK 1; Radiation

Indexed keywords

BIOMARKERS; GAMMA RAYS; HISTOLOGY; IMAGE ANALYSIS; IMMUNOLOGY; INTERFACES (COMPUTER);

BIODOSIMETRY; IMMUNOHISTROCHEMISTRY; LETHAL IRRADIATION; WHOLE-BODY IRRADIATION;

DOSIMETRY;

EID: 37049023039     PISSN: 0011748X     EISSN: None     Source Type: Journal    
DOI: 10.14429/dsj.57.1823     Document Type: Article

References (20)

1. Pellmar, T.C. & Rockwell, S. Radiological/nuclear threat countermeasures working group: Priority list of research areas for radiological nuclear threat countermeasures. Radiation Research, 2005, 163, 115-23.
2. Fajardo, L.F. Pathology of radiation injury. Masson Publishing, New York, 1982, p. 286.
3. Driak, D.; Österreicher, J.; Vilasova, Z. & Vavrova, J. Expression of phospho-Elk-1 in rat gut after the whole body γ-irradiation. Acta Histochemica, 2006, in press.
4. Suzuki, K.; Kodama, S. & Watanabe, M. Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. Cancer Research, 2001, 61, 5396-401.
5. Sui, M.; Dziadyk, J.M.; Zhu, X. & Fan, W. Cell cycle-dependent antagonistic interactions between paclitaxel and gamma-radiation in combination therapy. Clin. Cancer Res., 2004, 10, 4848-857.
6. Wang, T.; Hu, Y.C.; Dong, S.; Fan, M.; Tamae, D.; Oteku, M.; Gao, Q.; Gius, D. & Li, J.J. Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. J. Biol. Chem., 2005, 280, 12593-2601.
7. Kukushkin, A.N.; Aramova, M.V.; Svetlikova, S.B.; Darieva, Z.A.; Pospelova, T.V. & Pospelov, V.A. Downregulation of c-fos gene transcription in cells transformed by El A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-Fos promoter. Oncogene, 2002, 21, 719-30.
8. Wu, J.J.; Zhang, L. & Bennett, A.M. The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation. Mol. Cell Biol., 2005, 25, 4792-803.
9. Kato, F.; Kakihara, H.; Kunugita, N.; Ootsuyama, A. & Norimura, T. Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice. J. Radiat. Res., 2002, 43, S209-S212.
10. Narang, H. & Krishna, M. Mitogen-activated protein kinases: specifity of response to does of ionizing radiation in liver. J. Radiat. Res., 2004, 45, 213-20.
11. Vickers, E.R.; Kasza, A.; Kurnaz, I.A.; Seifert, A.; Zeef, L.A.; O'Donnell, A.; Hayes, A. & Sharrocks, A.D. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol. Cell Biol., 2004, 24, 10340-51.
12. Whitmarsh, A.J.; Yang, S.H.; Su, M.S.; Sharrocks, A.D. & Davis, R.J. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol. Cell Biol., 1997, 17, 2360-371.
13. Murata, M.; Kador, P.F. & Sato, S. Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells. J. Ocul Pharmacol. Ther, 2000, 16, 383-91.
14. Pusl, T.; Wu, J.J.; Zimmermann, T.L.; Zhang, L.; Ehrlich, B.E.; Berchtold, M.W.; Hoek, J.B.; Karpen, S.J.; Nathanson, M.H. & Bennett, A.M. Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-l requires nuclear calcium. J. Biol. Chem., 2002, 277, 27517-7527.
15. Lee, J.S.; Lee, J.J. & Seo, J.S. HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis. J. Biol. Chem., 2005, 280, 6634-641.
16. Gille, H.; Kortenjann, M.; Thomae, O.; Moomaw, C.; Slaughter, C.; Cobb, M.H. & Shaw, P.E. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO Journal, 1995, 14, 951-62.
17. Milne, D. M.; Campbell, D. G.; Caudwell, F. B. & Meek, D. W. Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases. J. Biol. Chem., 1995, 269, 9253-260.
18. Townsend, K.J.; Zhou, P.; Qian, L.P.; Bieszcad, C.K.; Lowrey, C.H.; Yen, A. & Craig, R.W. Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. J. Biol. Chem., 1999, 274, 1801-13.
19. Sautin, Y.Y.; Crawford, J.M.; Svetlov, S.I. Enhancement of survival by LPA via Erkl/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line. Am. J. Physiol. Cell Physiol., 2001, 281, C2010-209.
20. Szkanderova, S.; Vavrova, J.; Rezacova, M.; Vokurkova, D.; Pavlova, S.; Smardová, J. & Stulik, J. Gamma irradiation results in phosphorylation of p53 at serine-392 in human T-lymphocyte leukaemia cell line MOLT-4. Folia Biology, 2003, 49, 191-96.