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Volumn 2, Issue C, 2006, Pages 133-153

The medicinal potential of black seed (Nigella sativa) and its components

Author keywords

black seed; medicinal plants; N. sativa oil; nigella sativa; thymoquinone

Indexed keywords


EID: 55349146787     PISSN: 1572557X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1572-557X(05)02008-8     Document Type: Review
Times cited : (114)

References (110)
  • 1
    • 0034648056 scopus 로고    scopus 로고
    • Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone in mice
    • Abdel-Fattah A.M., Matsumoto K., and Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone in mice. Eur J Pharmacol 400 (2000) 89-97
    • (2000) Eur J Pharmacol , vol.400 , pp. 89-97
    • Abdel-Fattah, A.M.1    Matsumoto, K.2    Watanabe, H.3
  • 2
    • 2142761439 scopus 로고
    • The protective effect of Nigella sativa on bilharzial-induced liver injury in mice
    • Abdel-Salam I.M., Hassanein A.G., El-Sayed M.M., and Mokhtar N.M. The protective effect of Nigella sativa on bilharzial-induced liver injury in mice. Arab J Lab 19 (1993) 127-138
    • (1993) Arab J Lab , vol.19 , pp. 127-138
    • Abdel-Salam, I.M.1    Hassanein, A.G.2    El-Sayed, M.M.3    Mokhtar, N.M.4
  • 3
    • 0028985043 scopus 로고
    • TLC assay of thymoquinone in black seed oil (Nigella sativa Linn) and identification of dithymoquinone and thymol
    • Abou Basha L.I., Rashed M.S., and Aboul-Enein H.Y. TLC assay of thymoquinone in black seed oil (Nigella sativa Linn) and identification of dithymoquinone and thymol. J Liquid Chrom 18 (1995) 105-115
    • (1995) J Liquid Chrom , vol.18 , pp. 105-115
    • Abou Basha, L.I.1    Rashed, M.S.2    Aboul-Enein, H.Y.3
  • 4
    • 0029802022 scopus 로고    scopus 로고
    • Antimicrobial evaluation and chromatographic analysis of some essential and fixed oils
    • Aboul Ela M.A., El-Shaer N.S., and Ghanem N.B. Antimicrobial evaluation and chromatographic analysis of some essential and fixed oils. Pharmazie 51 (1996) 993-994
    • (1996) Pharmazie , vol.51 , pp. 993-994
    • Aboul Ela, M.A.1    El-Shaer, N.S.2    Ghanem, N.B.3
  • 5
    • 0037177574 scopus 로고    scopus 로고
    • Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping
    • Aboul-Ela E.I. Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. Mutat Res 516 (2002) 11-17
    • (2002) Mutat Res , vol.516 , pp. 11-17
    • Aboul-Ela, E.I.1
  • 6
    • 0028985834 scopus 로고
    • Simple HPLC method for the determination of thymoquinone in black seed oil (Nigella sativa Linn)
    • Aboul-Enein Y.H., and Abou-Basha I.L. Simple HPLC method for the determination of thymoquinone in black seed oil (Nigella sativa Linn). J Liquid Chrom 18 (1995) 895-902
    • (1995) J Liquid Chrom , vol.18 , pp. 895-902
    • Aboul-Enein, Y.H.1    Abou-Basha, I.L.2
  • 7
    • 0032914569 scopus 로고    scopus 로고
    • Antioxidant action of several β-adrenergic blockers and related compounds
    • Aboul-Enein H.Y., Kruk I., and Lichszteld K. Antioxidant action of several β-adrenergic blockers and related compounds. Toxicol Environ Chem 68 (1999) 349-361
    • (1999) Toxicol Environ Chem , vol.68 , pp. 349-361
    • Aboul-Enein, H.Y.1    Kruk, I.2    Lichszteld, K.3
  • 9
    • 0018611973 scopus 로고
    • Antimicrobial and anthelminthic activities of the essential oil of Nigella sativa Linn
    • Agarwal R., Kharya M.D., and Shrivastava R. Antimicrobial and anthelminthic activities of the essential oil of Nigella sativa Linn. Indian J Exp Biol 17 (1979) 1264-1265
    • (1979) Indian J Exp Biol , vol.17 , pp. 1264-1265
    • Agarwal, R.1    Kharya, M.D.2    Shrivastava, R.3
  • 10
    • 0025826841 scopus 로고
    • Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children
    • Akhtar M.S., and Riffat S. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. J Pak Med Assoc 41 (1991) 185-187
    • (1991) J Pak Med Assoc , vol.41 , pp. 185-187
    • Akhtar, M.S.1    Riffat, S.2
  • 11
    • 0026269341 scopus 로고
    • The effect of a plant's mixture extract on liver gluconeogenesis in streptozotocin-induced diabetic rats
    • Al-Awadi F., Fatania H., and Shamte U. The effect of a plant's mixture extract on liver gluconeogenesis in streptozotocin-induced diabetic rats. Diabetes Res 18 (1991) 163-168
    • (1991) Diabetes Res , vol.18 , pp. 163-168
    • Al-Awadi, F.1    Fatania, H.2    Shamte, U.3
  • 12
    • 0034987355 scopus 로고    scopus 로고
    • The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa
    • Al-Ghamdi M.S. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 76 (2001) 45-48
    • (2001) J Ethnopharmacol , vol.76 , pp. 45-48
    • Al-Ghamdi, M.S.1
  • 14
    • 0027309568 scopus 로고
    • Hypoglycemic effects of the volatile oil of Nigella sativa seeds
    • Al-Hader A.A., Aqel M.B., and Hasan Z.A. Hypoglycemic effects of the volatile oil of Nigella sativa seeds. Int J Pharmacogn 31 (1993) 96-100
    • (1993) Int J Pharmacogn , vol.31 , pp. 96-100
    • Al-Hader, A.A.1    Aqel, M.B.2    Hasan, Z.A.3
  • 15
    • 0036559925 scopus 로고    scopus 로고
    • Response of broiler chicks to dietary Rhazya stricta and Nigella sativa
    • Al-Homidan A., Al-Qarawi A.A., Al-Waily S.A., and Adam S.E. Response of broiler chicks to dietary Rhazya stricta and Nigella sativa. Br Poult Sci 43 (2002) 291-296
    • (2002) Br Poult Sci , vol.43 , pp. 291-296
    • Al-Homidan, A.1    Al-Qarawi, A.A.2    Al-Waily, S.A.3    Adam, S.E.4
  • 17
    • 0029978883 scopus 로고    scopus 로고
    • Effect of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig
    • Aqel M., and Shaheen R. Effect of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 52 (1996) 23-26
    • (1996) J Ethnopharmacol , vol.52 , pp. 23-26
    • Aqel, M.1    Shaheen, R.2
  • 18
    • 0032876393 scopus 로고    scopus 로고
    • Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
    • Badary O.A. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol 1 (1999) 135-142
    • (1999) J Ethnopharmacol , vol.1 , pp. 135-142
    • Badary, O.A.1
  • 19
    • 0033965801 scopus 로고    scopus 로고
    • The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
    • Badary O.A., Abdel-Naim A.B., Abdel-Wahab M.H., and Hamada F.M. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology 143 (2000) 219-226
    • (2000) Toxicology , vol.143 , pp. 219-226
    • Badary, O.A.1    Abdel-Naim, A.B.2    Abdel-Wahab, M.H.3    Hamada, F.M.4
  • 22
    • 0035237915 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis
    • Badary O.A., and Gamal El-Din A.M. Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. Cancer Detect Prev 25 (2001) 362-368
    • (2001) Cancer Detect Prev , vol.25 , pp. 362-368
    • Badary, O.A.1    Gamal El-Din, A.M.2
  • 24
    • 0030875392 scopus 로고    scopus 로고
    • Effect of oral ingestion of Nigella sativa seeds on some blood parameters
    • Bamosa A.O., Ali B.A., and Sowayan S.A. Effect of oral ingestion of Nigella sativa seeds on some blood parameters. Saudi Pharm J 5 (1997) 126-129
    • (1997) Saudi Pharm J , vol.5 , pp. 126-129
    • Bamosa, A.O.1    Ali, B.A.2    Sowayan, S.A.3
  • 25
    • 0022441229 scopus 로고
    • Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy
    • Bertani T., Cutillo F., Zoja C., Broggini M., and Remuzzi G. Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy. Kidney Int 30 (1986) 488-496
    • (1986) Kidney Int , vol.30 , pp. 488-496
    • Bertani, T.1    Cutillo, F.2    Zoja, C.3    Broggini, M.4    Remuzzi, G.5
  • 28
    • 0033837710 scopus 로고    scopus 로고
    • Antioxidant activity of Nigella sativa essential oil
    • Burits M., and Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res 14 (2000) 323-328
    • (2000) Phytother Res , vol.14 , pp. 323-328
    • Burits, M.1    Bucar, F.2
  • 29
    • 0027528479 scopus 로고
    • Inhibition of histamine release from mast cells by nigellone
    • Chakravarty N. Inhibition of histamine release from mast cells by nigellone. Ann Allergy 70 (1993) 237-242
    • (1993) Ann Allergy , vol.70 , pp. 237-242
    • Chakravarty, N.1
  • 32
    • 0032584004 scopus 로고    scopus 로고
    • Hepatoprotective activity of thymoquinone in isolated rat hepatocytes
    • Daba M.H., and Abdel-Rahman M.S. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 16 (1998) 23-29
    • (1998) Toxicol Lett , vol.16 , pp. 23-29
    • Daba, M.H.1    Abdel-Rahman, M.S.2
  • 33
    • 0030706057 scopus 로고    scopus 로고
    • The role of plant-derived drugs and herbal medicines in health care
    • De Smet P.A.G.M. The role of plant-derived drugs and herbal medicines in health care. Drugs 54 (1997) 801-840
    • (1997) Drugs , vol.54 , pp. 801-840
    • De Smet, P.A.G.M.1
  • 34
    • 0022444070 scopus 로고
    • Historical perspectives on the use of herbal preparations to promote health
    • Dubick M.A. Historical perspectives on the use of herbal preparations to promote health. J Nutr 116 (1986) 1348-1354
    • (1986) J Nutr , vol.116 , pp. 1348-1354
    • Dubick, M.A.1
  • 35
    • 0000988920 scopus 로고
    • Studies on the chemical constitution of the Egyptian Nigella sativa L. seeds
    • El-Dakhakhny M. Studies on the chemical constitution of the Egyptian Nigella sativa L. seeds. II: The essential oil. Planta Medica, 12 (1963) 465-470
    • (1963) II: The essential oil. Planta Medica , vol.12 , pp. 465-470
    • El-Dakhakhny, M.1
  • 36
    • 0013804161 scopus 로고
    • Studies on the Egyptian Nigella sativa L. IV Some pharmacological properties of seeds active principle in comparison to its dihydro compound and its polymer
    • El-Dakhakhny M. Studies on the Egyptian Nigella sativa L. IV Some pharmacological properties of seeds active principle in comparison to its dihydro compound and its polymer. Arzneim Forsch (Drug Res Germ) 15 (1965) 1227-1229
    • (1965) Arzneim Forsch (Drug Res Germ) , vol.15 , pp. 1227-1229
    • El-Dakhakhny, M.1
  • 37
    • 4243521393 scopus 로고    scopus 로고
    • Protective effect of Nigella sativa oil and clindamycin against production of TNF-α and liver injury in murine septic peritoritis
    • (abstract no. 12)
    • El-Dakhakhny M., El-Halim M., Aly S.M., and Barakat M.K. Protective effect of Nigella sativa oil and clindamycin against production of TNF-α and liver injury in murine septic peritoritis. Naunyn Schmiedeberg's Arch Pharmacol 362 (2000) R17 (abstract no. 12)
    • (2000) Naunyn Schmiedeberg's Arch Pharmacol , vol.362
    • El-Dakhakhny, M.1    El-Halim, M.2    Aly, S.M.3    Barakat, M.K.4
  • 38
    • 0034284791 scopus 로고    scopus 로고
    • Effects of Nigella sativa oil on gastric secretion and ethanol-induced ulcer in rats
    • El-Dakhakhny M., Barakat M., Abdel El-Halim M., and Aly S.M. Effects of Nigella sativa oil on gastric secretion and ethanol-induced ulcer in rats. J Ethnopharmacol 72 (2000) 299-304
    • (2000) J Ethnopharmacol , vol.72 , pp. 299-304
    • El-Dakhakhny, M.1    Barakat, M.2    Abdel El-Halim, M.3    Aly, S.M.4
  • 39
    • 0033800305 scopus 로고    scopus 로고
    • Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats
    • El-Dakhakhny M., Mady N.I., and Halim M.A. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneim Forsch 50 (2000) 832-836
    • (2000) Arzneim Forsch , vol.50 , pp. 832-836
    • El-Dakhakhny, M.1    Mady, N.I.2    Halim, M.A.3
  • 40
    • 0036277862 scopus 로고    scopus 로고
    • Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats
    • El-Dakhakhny M., Mady N.J., Lembert N., and Ammon H.P. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol 81 (2002) 161-164
    • (2002) J Ethnopharmacol , vol.81 , pp. 161-164
    • El-Dakhakhny, M.1    Mady, N.J.2    Lembert, N.3    Ammon, H.P.4
  • 41
    • 0036273437 scopus 로고    scopus 로고
    • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions
    • El-Dakhakhny M., Mady N., Lembert N., and Ammon H.P. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med 68 (2002) 465-466
    • (2002) Planta Med , vol.68 , pp. 465-466
    • El-Dakhakhny, M.1    Mady, N.2    Lembert, N.3    Ammon, H.P.4
  • 42
    • 0004903535 scopus 로고
    • Some pharmacological properties of some constituents of Nigella sativa L. seeds. The carbonyl fraction of the essential oil
    • Studies in Islamic Medicine and Advantages of Herbal treatment, Kuwait
    • El-Dakhakhany M. Some pharmacological properties of some constituents of Nigella sativa L. seeds. The carbonyl fraction of the essential oil. Proceedings of the Second International Conference on Islamic Medicine, 12th April (1982), Studies in Islamic Medicine and Advantages of Herbal treatment, Kuwait 246-431
    • (1982) Proceedings of the Second International Conference on Islamic Medicine, 12th April , pp. 246-431
    • El-Dakhakhany, M.1
  • 43
    • 0031863041 scopus 로고    scopus 로고
    • Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats
    • El-Daly E.S. Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J Pharmacol (Belgium) 53 (1998) 87-93
    • (1998) J Pharmacol (Belgium) , vol.53 , pp. 87-93
    • El-Daly, E.S.1
  • 44
    • 0016431808 scopus 로고
    • Isolation and structure assignment of an antimicrobial principle from the volatile oil of Nigella sativa L seeds
    • El-Fatatry H.M. Isolation and structure assignment of an antimicrobial principle from the volatile oil of Nigella sativa L seeds. Pharmazie 30 (1975) 109-111
    • (1975) Pharmazie , vol.30 , pp. 109-111
    • El-Fatatry, H.M.1
  • 45
    • 0000492114 scopus 로고
    • Effect of Nigella sativa (the black seeds) on immunity. Proceedings of the Fourth International Conference on Islamic Medicine
    • El-Kadi A., and Kandil O. Effect of Nigella sativa (the black seeds) on immunity. Proceedings of the Fourth International Conference on Islamic Medicine. Bull. Islamic Med, 4 (1986) 344-348
    • (1986) Bull. Islamic Med , vol.4 , pp. 344-348
    • El-Kadi, A.1    Kandil, O.2
  • 48
    • 0027290046 scopus 로고
    • The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea pigs: elucidation of the mechanism(s) of action
    • El-Tahir K.E., Ashour M.M., and Al-Harbi M.M. The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea pigs: elucidation of the mechanism(s) of action. Gen Pharmacol 24 (1993) 1115-1122
    • (1993) Gen Pharmacol , vol.24 , pp. 1115-1122
    • El-Tahir, K.E.1    Ashour, M.M.2    Al-Harbi, M.M.3
  • 49
    • 0027264732 scopus 로고
    • The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action
    • El-Tahir K.E., Ashour M.M., and Al-Harbi M.M. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 24 (1993) 1123-1131
    • (1993) Gen Pharmacol , vol.24 , pp. 1123-1131
    • El-Tahir, K.E.1    Ashour, M.M.2    Al-Harbi, M.M.3
  • 51
    • 0036901812 scopus 로고    scopus 로고
    • Insulinotropic properties of Nigella sativa oil in streptozotocin plus nicotinamide diabetic hamster
    • Fararh K.M., Atoji Y., Shimizu Y., and Takewaki T. Insulinotropic properties of Nigella sativa oil in streptozotocin plus nicotinamide diabetic hamster. Res Vet Sci 73 (2002) 279-282
    • (2002) Res Vet Sci , vol.73 , pp. 279-282
    • Fararh, K.M.1    Atoji, Y.2    Shimizu, Y.3    Takewaki, T.4
  • 52
    • 0029620247 scopus 로고
    • Hepatoprotective activity of xanthones and xanthonolignoids against tert-butylhydroperoxide-induced toxicity in isolated hepatocytes - comparison with silybin
    • Fernandez E.R., Carvalho F.D., Remiao F.G., Bastos M.L., Pinto M.M., and Gottlieb O.R. Hepatoprotective activity of xanthones and xanthonolignoids against tert-butylhydroperoxide-induced toxicity in isolated hepatocytes - comparison with silybin. Pharmacol Res 12 (1995) 1756-1760
    • (1995) Pharmacol Res , vol.12 , pp. 1756-1760
    • Fernandez, E.R.1    Carvalho, F.D.2    Remiao, F.G.3    Bastos, M.L.4    Pinto, M.M.5    Gottlieb, O.R.6
  • 53
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    • Gali-Muhtasib H., Diab-Assaf M., Boltze C., Al-Hmaira J., Hartig R., Roessner A., and Schneider-Stock R. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 25 4 (2004) 857-866
    • (2004) Int J Oncol , vol.25 , Issue.4 , pp. 857-866
    • Gali-Muhtasib, H.1    Diab-Assaf, M.2    Boltze, C.3    Al-Hmaira, J.4    Hartig, R.5    Roessner, A.6    Schneider-Stock, R.7
  • 56
    • 0033120349 scopus 로고    scopus 로고
    • High-performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed
    • Ghosheh O.A., Houdi A.A., and Crooks P.A. High-performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed. J Pharm Biomed Anal 19 (1999) 757-762
    • (1999) J Pharm Biomed Anal , vol.19 , pp. 757-762
    • Ghosheh, O.A.1    Houdi, A.A.2    Crooks, P.A.3
  • 57
    • 0035026610 scopus 로고    scopus 로고
    • Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses
    • Gilani A.H., Aziz N., Khurram I.M., Chaudhary K.S., and Iqbal A. Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses. J Pak Med Assoc 51 (2001) 115-120
    • (2001) J Pak Med Assoc , vol.51 , pp. 115-120
    • Gilani, A.H.1    Aziz, N.2    Khurram, I.M.3    Chaudhary, K.S.4    Iqbal, A.5
  • 58
    • 0025914525 scopus 로고
    • Studies on the antimicrobial activity of Nigella sativa seed (black cumin)
    • Hanafy M.S., and Hatem M.E. Studies on the antimicrobial activity of Nigella sativa seed (black cumin). J Ethnopharmacol 34 (1991) 275-278
    • (1991) J Ethnopharmacol , vol.34 , pp. 275-278
    • Hanafy, M.S.1    Hatem, M.E.2
  • 59
    • 0029100394 scopus 로고
    • Nigella sativa: effect on human lymphocytes and polymorphonuclear leucocyte phagocytic activity
    • Haq A., Adbullatif M., Labo P., Khabar K., Sheth K., and AlSedairy S. Nigella sativa: effect on human lymphocytes and polymorphonuclear leucocyte phagocytic activity. Immunopharmacology 30 (1995) 147-155
    • (1995) Immunopharmacology , vol.30 , pp. 147-155
    • Haq, A.1    Adbullatif, M.2    Labo, P.3    Khabar, K.4    Sheth, K.5    AlSedairy, S.6
  • 60
    • 0033012875 scopus 로고    scopus 로고
    • Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography
    • Haq A., Lobo P.I., Al-Tufail M., Rama N.R., and Al-Sedairy S.T. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol 21 (1999) 283-295
    • (1999) Int J Immunopharmacol , vol.21 , pp. 283-295
    • Haq, A.1    Lobo, P.I.2    Al-Tufail, M.3    Rama, N.R.4    Al-Sedairy, S.T.5
  • 62
    • 0009463944 scopus 로고
    • Effect of some Nigella sativa constituents on chemical carcinogenesis in hamster cheek pouch
    • Hassan M., and El-Dakhakhny M. Effect of some Nigella sativa constituents on chemical carcinogenesis in hamster cheek pouch. J Egyptian Soc PharmacolExp Therap 11 (1992) 675-677
    • (1992) J Egyptian Soc PharmacolExp Therap , vol.11 , pp. 675-677
    • Hassan, M.1    El-Dakhakhny, M.2
  • 63
    • 0025128542 scopus 로고
    • 2-induced hepatocyte plasma membrane bleb formation by certain prostaglandins and a proteinase inhibitor
    • 2-induced hepatocyte plasma membrane bleb formation by certain prostaglandins and a proteinase inhibitor. Biochim Biophys Acta 1022 (1990) 319-324
    • (1990) Biochim Biophys Acta , vol.1022 , pp. 319-324
    • Horton, A.A.1    Wood, J.M.2
  • 65
    • 0028852880 scopus 로고
    • Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation
    • Houghton P.J., Zarka R., De las Heras B., and Hoult R.S. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Medica 61 (1995) 33-36
    • (1995) Planta Medica , vol.61 , pp. 33-36
    • Houghton, P.J.1    Zarka, R.2    De las Heras, B.3    Hoult, R.S.4
  • 66
    • 0026665366 scopus 로고
    • The pharmacology of extinction
    • Huxtable R.J. The pharmacology of extinction. J Ethnopharmacol 37 (1992) 1-11
    • (1992) J Ethnopharmacol , vol.37 , pp. 1-11
    • Huxtable, R.J.1
  • 68
    • 0033059343 scopus 로고    scopus 로고
    • Chemical composition and medicinal properties of Nigella sativa Linn
    • Khan M.A. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology 7 (1999) 15-35
    • (1999) Inflammopharmacology , vol.7 , pp. 15-35
    • Khan, M.A.1
  • 69
    • 0021198432 scopus 로고
    • Mechanism of antihepatotoxic activity of glycerrhizin. Effect of free radical generation and lipid peroxidation
    • Kiso Y., Tohkin M., Hikine H., Hattori M., Sakamoto T., and Namba T. Mechanism of antihepatotoxic activity of glycerrhizin. Effect of free radical generation and lipid peroxidation. Planta Med 50 (1984) 298-302
    • (1984) Planta Med , vol.50 , pp. 298-302
    • Kiso, Y.1    Tohkin, M.2    Hikine, H.3    Hattori, M.4    Sakamoto, T.5    Namba, T.6
  • 70
    • 0034120730 scopus 로고    scopus 로고
    • The effect of thymol and its derivatives on reactions generating reactive oxygen species
    • Kruk I., Michalska T., Lichszteld K., Kladna A., and Aboul-Enein H.Y. The effect of thymol and its derivatives on reactions generating reactive oxygen species. Chemosphere 41 (2000) 1059-1064
    • (2000) Chemosphere , vol.41 , pp. 1059-1064
    • Kruk, I.1    Michalska, T.2    Lichszteld, K.3    Kladna, A.4    Aboul-Enein, H.Y.5
  • 71
    • 0035098984 scopus 로고    scopus 로고
    • Extraction, isolation and characterisation of antitumor principle, α-hederin, from the seeds of Nigella sativa
    • Kumara S.S., and Huat B.T. Extraction, isolation and characterisation of antitumor principle, α-hederin, from the seeds of Nigella sativa. Planta Med 67 (2001) 29-32
    • (2001) Planta Med , vol.67 , pp. 29-32
    • Kumara, S.S.1    Huat, B.T.2
  • 72
    • 0002294671 scopus 로고    scopus 로고
    • Actio anti-obesite, hypocholesterolemiante et hypotriglyceridemiante de Nigella sativa chez le Psammomys obesus
    • Labhal A., Settaf A., Bennani-kabchi N., Cherrah Y., Slaoui A., and Hassar M. Actio anti-obesite, hypocholesterolemiante et hypotriglyceridemiante de Nigella sativa chez le Psammomys obesus. Caducee 27 (1997) 26-28
    • (1997) Caducee , vol.27 , pp. 26-28
    • Labhal, A.1    Settaf, A.2    Bennani-kabchi, N.3    Cherrah, Y.4    Slaoui, A.5    Hassar, M.6
  • 73
    • 0036736903 scopus 로고    scopus 로고
    • Inhibition of methylnitrosourea (MNU)-induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawley rats
    • Mabrouk G.M., Moselhy S.S., Zohny S.F., Ali E.M., Helal T.E., Amin A.A., and Khalifa A.A. Inhibition of methylnitrosourea (MNU)-induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawley rats. J Exp Clin Cancer Res 21 (2002) 341-346
    • (2002) J Exp Clin Cancer Res , vol.21 , pp. 341-346
    • Mabrouk, G.M.1    Moselhy, S.S.2    Zohny, S.F.3    Ali, E.M.4    Helal, T.E.5    Amin, A.A.6    Khalifa, A.A.7
  • 75
    • 0001645850 scopus 로고
    • The effect of ''nigellone therapy'' on the histaminopexic power of the blood sera in asthmatic patients
    • Mahfouz M., Abdel-Maguid R., and El-Dakhakhny M. The effect of ''nigellone therapy'' on the histaminopexic power of the blood sera in asthmatic patients. Arzneim Forsch (Drug Res.), 15 (1965) 1230-1234
    • (1965) Arzneim Forsch (Drug Res.) , vol.15 , pp. 1230-1234
    • Mahfouz, M.1    Abdel-Maguid, R.2    El-Dakhakhny, M.3
  • 76
    • 0001900638 scopus 로고
    • The isolation of a crystalline active principle from Nigella sativa L. seeds
    • Mahfouz M., and El-Dakhakhny M. The isolation of a crystalline active principle from Nigella sativa L. seeds. J Pharm Sci United Arab Republic 1 (1960) 9-19
    • (1960) J Pharm Sci United Arab Republic , vol.1 , pp. 9-19
    • Mahfouz, M.1    El-Dakhakhny, M.2
  • 77
    • 0036136661 scopus 로고    scopus 로고
    • The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice
    • Mahmoud M.R., El-Abhar H.S., and Saleh S. The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice. J Ethnopharmacol 79 (2002) 1-11
    • (2002) J Ethnopharmacol , vol.79 , pp. 1-11
    • Mahmoud, M.R.1    El-Abhar, H.S.2    Saleh, S.3
  • 78
    • 0034686073 scopus 로고    scopus 로고
    • Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice
    • Mansour M.A. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci. 66 (2000) 2583-2591
    • (2000) Life Sci. , vol.66 , pp. 2583-2591
    • Mansour, M.A.1
  • 79
    • 0036090986 scopus 로고    scopus 로고
    • Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action
    • Mansour M.A., Nagi M.N., El-Khatib A.S., and Al-Bekairi A.M. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell. Biochem. Funct. 20 (2002) 143-151
    • (2002) Cell. Biochem. Funct. , vol.20 , pp. 143-151
    • Mansour, M.A.1    Nagi, M.N.2    El-Khatib, A.S.3    Al-Bekairi, A.M.4
  • 80
    • 0024503507 scopus 로고
    • Tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids
    • Masaki N., Kyle M.E., and Farber J.L. Tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Arch Biochem Biophys 269 (1989) 390-399
    • (1989) Arch Biochem Biophys , vol.269 , pp. 390-399
    • Masaki, N.1    Kyle, M.E.2    Farber, J.L.3
  • 81
    • 0035752777 scopus 로고    scopus 로고
    • Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally induced diabetic rabbits
    • Meral I., Yener Z., Kahraman T., and Mert N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally induced diabetic rabbits. J Vet Med A Physiol Pathol Clin Med 48 (2001) 593-599
    • (2001) J Vet Med A Physiol Pathol Clin Med , vol.48 , pp. 593-599
    • Meral, I.1    Yener, Z.2    Kahraman, T.3    Mert, N.4
  • 82
    • 0028301966 scopus 로고
    • Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2EI
    • Miguez M., Anundi I., Sainz-Pardo L., and Lindros K.O. Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2EI. Chem Biol Interact. 91 (1994) 51-63
    • (1994) Chem Biol Interact. , vol.91 , pp. 51-63
    • Miguez, M.1    Anundi, I.2    Sainz-Pardo, L.3    Lindros, K.O.4
  • 83
    • 0033945636 scopus 로고    scopus 로고
    • Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria
    • Morsi N.M. Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria. Acta Microbiol Pol 49 (2000) 63-74
    • (2000) Acta Microbiol Pol , vol.49 , pp. 63-74
    • Morsi, N.M.1
  • 84
    • 0010417597 scopus 로고
    • Crocus sativus, Nigella sativa
    • Nadkarni K.M. (Ed), Popular Prakashan, Bombay, India
    • Nadkarni K. Crocus sativus, Nigella sativa. In: Nadkarni K.M. (Ed). Indian materia medica (1976), Popular Prakashan, Bombay, India 386-411
    • (1976) Indian materia medica , pp. 386-411
    • Nadkarni, K.1
  • 86
    • 0033836675 scopus 로고    scopus 로고
    • Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection
    • Nagi M.N., and Mansour M.A. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res 41 (2000) 283-289
    • (2000) Pharmacol Res , vol.41 , pp. 283-289
    • Nagi, M.N.1    Mansour, M.A.2
  • 87
    • 0025956720 scopus 로고
    • Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice
    • Nair S.C., Salomi M.J., Panikkar B., and Panikkar K.R. Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice. J Ethnopharmacol 31 (1991) 75-83
    • (1991) J Ethnopharmacol , vol.31 , pp. 75-83
    • Nair, S.C.1    Salomi, M.J.2    Panikkar, B.3    Panikkar, K.R.4
  • 88
    • 0027321652 scopus 로고
    • Free radical scavenger and antihepatotoxic activity of Rosemarinus tomentosus
    • Navaro M.C., Montilla M.P., Martin A., Jimenez J., and Utrilla M.P. Free radical scavenger and antihepatotoxic activity of Rosemarinus tomentosus. Planta Med 53 (1993) 312-314
    • (1993) Planta Med , vol.53 , pp. 312-314
    • Navaro, M.C.1    Montilla, M.P.2    Martin, A.3    Jimenez, J.4    Utrilla, M.P.5
  • 89
    • 0027420541 scopus 로고
    • Experimental murine cytomegalovirus infection in severe combined immunodeficient mice
    • Reynolds P., Rahija J., Schenkman I., and Richter B. Experimental murine cytomegalovirus infection in severe combined immunodeficient mice. Lab Anim Sci 43 (1993) 291-295
    • (1993) Lab Anim Sci , vol.43 , pp. 291-295
    • Reynolds, P.1    Rahija, J.2    Schenkman, I.3    Richter, B.4
  • 90
    • 0034286955 scopus 로고    scopus 로고
    • Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection
    • Salem M.L., and Hossain M.S. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol 22 9 (2000) 729-740
    • (2000) Int J Immunopharmacol , vol.22 , Issue.9 , pp. 729-740
    • Salem, M.L.1    Hossain, M.S.2
  • 91
    • 0025774015 scopus 로고
    • Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice
    • Salomi N.J., Nair S.C., and Panikkar K.R. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nut Cancer 16 (1991) 67-72
    • (1991) Nut Cancer , vol.16 , pp. 67-72
    • Salomi, N.J.1    Nair, S.C.2    Panikkar, K.R.3
  • 93
    • 0000762754 scopus 로고
    • Antimicrobial activity of seeds of some ethnopharmacinal plants
    • Saxena A., and Vyas K. Antimicrobial activity of seeds of some ethnopharmacinal plants. J Econ Taxon Botany 8 (1986) 291-299
    • (1986) J Econ Taxon Botany , vol.8 , pp. 291-299
    • Saxena, A.1    Vyas, K.2
  • 94
    • 0028334997 scopus 로고
    • The role of thiols in mitochondrial susceptibility to iron and tert-butyl hydroperoxide-mediated toxicity in cultured hepatocytes
    • Shertzer H.G., Bannenberg H., Zhu R.M., and Moldeus P. The role of thiols in mitochondrial susceptibility to iron and tert-butyl hydroperoxide-mediated toxicity in cultured hepatocytes. Chem Res Toxicol 7 (1994) 358-366
    • (1994) Chem Res Toxicol , vol.7 , pp. 358-366
    • Shertzer, H.G.1    Bannenberg, H.2    Zhu, R.M.3    Moldeus, P.4
  • 95
    • 0012980550 scopus 로고    scopus 로고
    • In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone
    • Shoieb A.M., Elgayyar M., Dudrick P.S., Bell J.L., and Tithof P.K. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 22 (2003) 107-113
    • (2003) Int J Oncol , vol.22 , pp. 107-113
    • Shoieb, A.M.1    Elgayyar, M.2    Dudrick, P.S.3    Bell, J.L.4    Tithof, P.K.5
  • 97
    • 0030947542 scopus 로고    scopus 로고
    • Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use
    • Steinmann A., Schatzle M., Agathos M., and Breit R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis 36 (1997) 268-269
    • (1997) Contact Dermatitis , vol.36 , pp. 268-269
    • Steinmann, A.1    Schatzle, M.2    Agathos, M.3    Breit, R.4
  • 98
    • 0034108281 scopus 로고    scopus 로고
    • Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L seeds
    • Swamy S.M., and Tan B.K. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L seeds. J Ethnopharmacol 70 (2000) 1-7
    • (2000) J Ethnopharmacol , vol.70 , pp. 1-7
    • Swamy, S.M.1    Tan, B.K.2
  • 100
    • 0029587132 scopus 로고
    • Protective effects of Osbeckia octandra against galactosamine and tert-butyl hydroperoxide-induced hepatocyte damage
    • Thabrew M.I., Gove C.D., Hughes R.D., McFarlane I.G., and Williams R. Protective effects of Osbeckia octandra against galactosamine and tert-butyl hydroperoxide-induced hepatocyte damage. J Ethnopharm 49 (1995) 69-76
    • (1995) J Ethnopharm , vol.49 , pp. 69-76
    • Thabrew, M.I.1    Gove, C.D.2    Hughes, R.D.3    McFarlane, I.G.4    Williams, R.5
  • 101
    • 0013820159 scopus 로고
    • The antibacterial properties of Nigella sativa seeds. Active principle with some clinical applications
    • Topozada H.H., Mazolum H.A., and El-Dakhakhny M. The antibacterial properties of Nigella sativa seeds. Active principle with some clinical applications. J Egypt Med Assoc 48 (1965) 187-202
    • (1965) J Egypt Med Assoc , vol.48 , pp. 187-202
    • Topozada, H.H.1    Mazolum, H.A.2    El-Dakhakhny, M.3
  • 102
    • 0021886538 scopus 로고
    • Isolation and structure of determination of nigellicine, a novel alkaloid from the seeds of Nigella sativa
    • ur-Rahman A., Malik S., Cunheng H., and Clardy J. Isolation and structure of determination of nigellicine, a novel alkaloid from the seeds of Nigella sativa. Tetrahedron Lett 26 (1985) 2759-2762
    • (1985) Tetrahedron Lett , vol.26 , pp. 2759-2762
    • ur-Rahman, A.1    Malik, S.2    Cunheng, H.3    Clardy, J.4
  • 103
    • 0022872988 scopus 로고
    • Antioxidant properties of the flavonoids silybin and +{plus 45 degree rule}- cyanidanol-3: comparison with butylated hydroxyanisole and butylated hydroxytoluene
    • Valenzuela A., Guera R., and Videla L.A. Antioxidant properties of the flavonoids silybin and +{plus 45 degree rule}- cyanidanol-3: comparison with butylated hydroxyanisole and butylated hydroxytoluene. Planta Med 52 (1986) 438-440
    • (1986) Planta Med , vol.52 , pp. 438-440
    • Valenzuela, A.1    Guera, R.2    Videla, L.A.3
  • 105
    • 0031878048 scopus 로고    scopus 로고
    • The in vitro anti-tumor activity of some crude and purified components of black seed, Nigella sativa L
    • Worthen D., Ghosheh O., and Crooks P. The in vitro anti-tumor activity of some crude and purified components of black seed, Nigella sativa L. Anticancer Res 18 (1998) 1527-1532
    • (1998) Anticancer Res , vol.18 , pp. 1527-1532
    • Worthen, D.1    Ghosheh, O.2    Crooks, P.3
  • 107
    • 0034186616 scopus 로고    scopus 로고
    • Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat
    • Zaoui A., Cherrah Y., Lacaille-Dubois M.A., Settaf A., Amarouch H., and Hassar M. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie 5 (2000) 379-382
    • (2000) Therapie , vol.5 , pp. 379-382
    • Zaoui, A.1    Cherrah, Y.2    Lacaille-Dubois, M.A.3    Settaf, A.4    Amarouch, H.5    Hassar, M.6
  • 109
    • 0036095178 scopus 로고    scopus 로고
    • Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment
    • Zedlitz S., Kaufmann R., and Boehncke W.H. Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment. Contact Dermatitis 46 (2002) 188
    • (2002) Contact Dermatitis , vol.46 , pp. 188
    • Zedlitz, S.1    Kaufmann, R.2    Boehncke, W.H.3


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