Overexpression of the aldose reductase GRE3 suppresses lithium-induced galactose toxicity in Saccharomyces cerevisiae

FEMS Yeast Research

Volumn 8, Issue 8, 2008, Pages 1245-1253

  Masuda, Claudio A ^a   Previato, Jose O ^a   Miranda, Michel N ^a   Assis, Leandro J ^a   Penha, Luciana L ^a   Mendonça Previato, Lucia ^a   Montero Lomelí, Mónica ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Aldose reductase; Galactokinase; Galactosemia; Inositol monophosphatase; Lithium; Saccharomyces cerevisiae

Indexed keywords

ALDEHYDE REDUCTASE; GALACTOSE; INOSITOL PHOSPHATE; LITHIUM;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FUNGUS GROWTH; GALACTOSEMIA; GENE OVEREXPRESSION; GROWTH INHIBITION; NONHUMAN; SACCHAROMYCES CEREVISIAE;

ALDEHYDE REDUCTASE; ANTIMANIC AGENTS; GALACTOKINASE; GALACTOSE; GALACTOSEPHOSPHATES; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; LITHIUM; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UP-REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 55349137056     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2008.00440.x     Document Type: Article

References (41)

1. Ai Y, Zheng Z, O'Brien-Jenkins A, Bernard DJ, Wynshaw-Boris T, Ning C, Reynolds R, Segal S, Huang K Stambolian D (2000) A mouse model of galactose-induced cataracts. Human Mol Genet 9 : 1821 1827.
2. Boles E, Liebetrau W, Hofmann M Zimmermann FK (1994) A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem 220 : 83 96.
3. Bosch AM (2006) Classical galactosaemia revisited. J Inherit Metab Dis 29 : 516 525.
4. Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, Hieter P Boeke JD (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14 : 115 132.
5. Bro C, Regenberg B, Lagniel G, Labarre J, Montero-Lomelí M Nielsen JJ (2003) Transcriptional, proteomic, and metabolic responses to lithium in galactose-grown yeast cells. J Biol Chem 278 : 32141 32149.
6. Dichtl B, Stevens A Tollervey D (1997) Lithium toxicity in yeast is due to the inhibition of RNA processing enzymes. EMBO J 16 : 7184 7195.
7. Douglas HC (1961) A mutation in Saccharomyces that affects phosphoglucomutase activity and galactose utilization. Biochim Biophys Acta 52 : 209 211.
8. Douglas HC Hawthorne DC (1964) Enzymatic expression and genetic linkage of genes controlling galactose utilization in Saccharomyces. Genetics 49 : 837 844.
9. Fekete E, Karaffa L, Sándor E, Bányai I, Seiboth B, Gyémánt G, Sepsi A, Szentirmai A Kubicek CP (2004) The alternative d-galactose degrading pathway of Aspergillus nidulans proceeds via l-sorbose. Arch Microbiol 181 : 35 44.
10. Ford G Ellis EM (2002) Characterization of Ypr1p from Saccharomyces cerevisiae as a 2-methylbutyraldehyde reductase. Yeast 19 : 1087 1096.
11. Fridovich-Keil JL (2006) Galactosemia: the good, the bad, and the unknown. J Cell Physiol 209 : 701 705.
12. Garay-Arroyo A Covarrubias AA (1999) Three genes whose expression is induced by stress in Saccharomyces cerevisiae. Yeast 15 : 879 892.
13. Gonzalez B, François J Renaud M (1997) A rapid and reliable method for metabolite extraction in yeast using boiling buffered ethanol. Yeast 13 : 1347 1356.
14. Hashimoto H, Kikuchi Y, Nogi Y Fukasawa T (1983) Regulation of expression of the galactose gene cluster in Saccharomyces cerevisiae. Isolation and characterization of the regulatory gene GAL4. Mol Gen Genet 191 : 31 38.
15. Kalckar HM (1957) Defect in uptake of galactose-1-phosphate into liver nucleotides in congenital galactosemia. Science 125 : 105 108.
16. Keegan L, Gill G Ptashne M (1986) Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science 231 : 699 704.
17. Kosterlitz HW (1943) The fermentation of galactose and galactose-1-phosphate. Biochem J 37 : 322 326.
18. Leloir LF (1951) The enzymatic transformation of uridine diphosphate glucose into a galactose derivative. Arch Biochem 33 : 186 190.
19. Lohr D, Venkov P Zlatanova J (1995) Transcriptional regulation in the yeast GAL gene family: a complex genetic network. FASEB J 9 : 777 787.
20. Lopez F, Leube M, Gil-Mascarell R, Navarro-Aviñó JP Serrano R (1999) The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair. Mol Microbiol 31 : 1255 1264.
21. Lowry OH, Rosebrough NJ, Farr AL Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193 : 265 275.
22. Masuda CA, Xavier MA, Mattos KA, Galina A Montero-Lomeli M (2001) Phosphoglucomutase is an in vivo lithium target in yeast. J Biol Chem 276 : 37794 37815.
23. Mehta DV, Kabir A Bhat PJ (1999) Expression of human inositol monophosphatase suppresses galactose toxicity in Saccharomyces cerevisiae: possible implications in galactosemia. Biochim Biophys Acta 1454 : 217 226.
24. Nakamura K, Kondo S, Kawai Y, Nakajima N Ohno A (1997) Amino acid sequence and characterization of aldo-keto reductase from bakers' yeast. Biosci Biotechnol Biochem 61 : 375 377.
25. Oh D Hopper JE (1990) Transcription of a yeast phosphoglucomutase isozyme gene is galactose inducible and glucose repressible. Mol Cell Biol 10 : 1415 1422.
26. Parthasarathy R, Parthasarathy L Vadnal R (1997) Brain inositol monophosphatase identified as a galactose 1-phosphatase. Brain Res 778 : 99 106.
27. Petrash JM, Murthy BS, Young M, Morris K, Rikimaru L, Griest TA Harter T (2001) Functional genomic studies of aldo-keto reductases. Chem Biol Interact 130-132 : 673 683.
28. Ray WJ Jr., Szymanki ES Ng L (1978) The binding of lithium and of anionic metabolites to phosphoglucomutase. Biochim Biophys Acta 522 : 434 442.
29. Rhyu GI, Ray WJ Jr. Markley JL (1984) Enzyme-bound intermediates in the conversion of glucose 1-phosphate to glucose 6-phosphate by phosphoglucomutase. Phosphorus NMR studies. Biochemistry 23 : 252 260.
30. Robichon-Szulmajster H (1958) Induction of enzymes of the galactose pathway in mutants of Saccharomyces cerevisiae. Science 127 : 28 29.
31. Ross KL, Davis CN Fridovich-Keil JL (2004) Differential roles of the Leloir pathway enzymes and metabolites in defining galactose sensitivity in yeast. Mol Genet Metab 83 : 103 116.
32. Schell MA Wilson DB (1977) Purification and properties of galactokinase from Saccharomyces cerevisiae. J Biol Chem 252 : 1162 1166.
33. Segawa T Fukasawa T (1979) The enzymes of the galactose cluster in Saccharomyces cerevisiae. Purification and characterization of galactose-1-phosphate uridylyltransferase. J Biol Chem 254 : 10707 10709.
34. Shakeri-Garakani A, Brinkkötter A, Schmid K, Turgut S Lengeler JW (2004) The genes and enzymes for the catabolism of galactitol, d-tagatose, and related carbohydrates in Klebsiella oxytoca M5a1 and other enteric bacteria display convergent evolution. Mol Genet Genomics 271 : 717 728.
35. Slepak T, Tang M, Addo F Lai K (2005) Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model. Mol Genet Metab 86 : 360 371.
36. Szumiło T (1981) An alternative route for d-galactose catabolism shared with that for dulcitol degradation route in mycobacteria. FEBS Lett 124 : 270 272.
37. Thevelein JM Hohmann S (1995) Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem Sci 20 : 3 10.
38. Thoden JB, Wohlers TM, Fridovich-Keil JL Holden HM (2001) Molecular basis for severe epimerase deficiency galactosemia. X-ray structure of the human V94M-substituted UDP-galactose 4-epimerase. J Biol Chem 276 : 20617 20623.
39. Timson DJ (2006) The structural and molecular biology of type III galactosemia. IUBMB Life 58 : 83 89.
40. Walter JH, Roberts RE, Besley GT, Wraith JE, Cleary MA, Holton JB MacFaul R (1999) Generalised uridine diphosphate galactose-4-epimerase deficiency. Arch Dis Child 80 : 374 376.
41. York JD, Ponder JW Majerus PW (1995) Definition of a metal-dependent/ Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. Proc Natl Acad Sci USA 92 : 5149 5153.