UCP-mediated free fatty acid uncoupling of isolated cortical mitochondria from fasted animals: Correlations to dietary modulations

Epilepsia

Volumn 49, Issue SUPPL. 8, 2008, Pages 117-119

  Davis, Laurie M ^a   Rho, Jong M ^b   Sullivan, Patrick G ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b BARROW NEUROLOGICAL INSTITUTE   (United States)

^c 375 BBSRB ^*  (United States)

Author keywords

Calorie reduction; Fasting; Free fatty acids; Ketogenic diet; Mitochondria; Reactive oxygen species; Trauma

Indexed keywords

ARACHIDONIC ACID; BUTYRIC ACID; DOCOSAHEXAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; MYRISTIC ACID; OLIGOMYCIN; PALMITOLEIC ACID; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2;

CONFERENCE PAPER; DIET; EPILEPSY; KETOGENIC DIET; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRAUMATIC BRAIN INJURY;

ANIMALS; CEREBRAL CORTEX; FASTING; FATTY ACIDS, NONESTERIFIED; ION CHANNELS; KETOGENIC DIET; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; UNCOUPLING AGENTS;

EID: 55349116766     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01854.x     Document Type: Conference Paper

References (12)

1. Davis LM, Pauly JR, Readnower RD, Rho JM, Sullivan PG 2008) Fasting is neuroprotective following traumatic brain injury. J Neurosci Res 86 : 1812 1822.
2. Debril MB, Renaud JP, Fajas L, Auwerx J 2001) The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med 79 : 30 47.
3. Echtay KS, Pakay JL, Esteves TC, Brand MD 2005) Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage. Biofactors 24 : 119 130.
4. Kiec-Wilk B, Dembinska-Kiec A, Olszanecka A, Bodzioch M, Kawecka-Jaszcz K 2005) The selected pathophysiological aspects of PPARs activation. J Physiol Pharmacol 56 : 149 162.
5. Lane N 2006) Power, sex, suicide: mitochondria and the meaning of life. Oxford University Press, New York, Oxford.
6. Liang LP, Patel M 2004) Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice. Free Radic Biol Med 36 : 542 554.
7. Nicholls DG, Budd SL 2000) Mitochondria and neuronal survival. Physiol Rev 80 : 315 360.
8. Nicholls DG, Fergusonb SJ 2002) Bioenergetics 3. Academic Press, Boston.
9. Patel M, Li QY 2003) Age dependence of seizure-induced oxidative stress. Neuroscience 118 : 431 437.
10. Sleven H, Gibbs JE, Heales S, Thom M, Cock HR 2006). Depletion of reduced glutathione precedes inactivation of mitochondrial enzymes following limbic status epilepticus in the rat hippocampus. Neurochem Int 48 : 75 82.
11. Sullivan PG, Dube C, Dorenbos K, Steward O, Baram TZ 2003) Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol 53 : 711 717.
12. Sullivan PG, Rippy N, Dorenbos K, Concepcion R, Agarwal A, Rho JM. (2004) The ketogenic diet increases mitochondrial uncoupling protein levels and activity in mouse hippocampus. Ann Neurol 55 : 576 580.