Simple and efficient synthesis of racemic substituted mandelic acid esters from nonactivated arenes and ethyl glyoxylate

Synthesis

Volumn , Issue 20, 2008, Pages 3237-3244

  Kwiatkowski, Jacek ^a   Majer, Jakub ^a   Kwiatkowski, Piotr ^a   Jurczak, Janusz ^a,b  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

Hydroxy esters; Arenes; Ethyl glyoxylate; Friedel Crafts hydroxyalkylation; Lewis acids; Mandelic acids

Indexed keywords

ALKYLATION; AROMATIC COMPOUNDS; CHEMICAL REACTIONS; ESTERIFICATION; ESTERS; FRIEDEL-CRAFTS REACTION; HYDROCARBONS; ORGANIC COMPOUNDS;

ARENES; ETHYL GLYOXYLATE; FRIEDEL-CRAFTS HYDROXYALKYLATION; LEWIS ACIDS; MANDELIC ACIDS;

ACIDS;

EHYL (3,4 DIMETHYLPHENYL)(HYDROXY)ACETATE; ESTER DERIVATIVE; ETHYL (2,4 DIMETHYLPHENYL)(HYDROXY)ACETATE; ETHYL (2,5 DIMETHYLPHENYL)(HYDROXY)ACETATE; ETHYL 1,4 DIHYDROANTHRACEN 9 YL(HYDROXY)ACETATE; ETHYL 4 TERT BUTYLPHENYL(HYDROXY)ACETATE; ETHYL 9H FLUOREN 2 YL(HYDROXY)ACETATE; ETHYL BIPHENYL 4 YL(HYDROXY)ACETATE; ETHYL CHRYSEN 6 YL(HYDROXY)ACETATE; ETHYL HYDROXY(2,3,5,6 TETRAMETHYLPHENYL)ACETATE; ETHYL HYDROXY(4 ISOPROPYLPHENYL)ACETATE; ETHYL HYDROXY(4 METHYL NAPHTHALEN 1 YL)ACTETATE; ETHYL HYDROXY(4 METHYLPHENYL)ACETATE; ETHYL HYDROXY(MESITYL)ACETATE; ETHYL HYDROXY(NAPHTHALEN 1 YL)ACETATE; MANDELIC ACID; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; FRIEDEL CRAFTS REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 55349114747     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1083154     Document Type: Article

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