No association between the protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 7, 2008, Pages 1013-1018

  Ito, Yoshihito ^a   Yamada, Shinnosuke ^b   Takahashi, Nagahide ^a,d   Saito, Shinichi ^a   Yoshimi, Akira ^b   Inada, Toshiya ^c   Noda, Yukihiro ^b   Ozaki, Norio ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Association study; ERBB4; HapMap; Linkage disequilibrium; NRG1

Indexed keywords

PHOSPHODIESTERASE I; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE Z POLYPEPTIDE 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; JAPAN; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 5; SCHIZOPHRENIA;

EID: 55349090680     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30692     Document Type: Article

References (35)

1. Balding DJ. 2006. A tutorial on statistical methods for population association studies. Nat Rev Genet 7(10):781-791.
2. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotypemaps. Bioinformatics 21(2):263-265.
3. Braff DL, Freedman R, Schork NJ, Gottesman II. 2007. Deconstructing schizophrenia: An overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 33(1):21-32.
4. Buxbaum JD, Georgieva L, Young JJ, Plescia C, Kajiwara Y, Jiang Y, Moskvina V, Norton N, Peirce T, Williams H, Craddock NJ, Carroll L, Corfas G, Davis KL, Owen MJ, Harroch S, Sakurai T, O'Donovan MC. 2007. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Mol Psychiatry. (advance online publication, 17 April 2007) DOI: 10.1038/sj.mp.4001991.
5. Chakravarti A. 1999. Population genetics - Making sense out of sequence. Nat Genet 21(1 Suppl):56-60.
6. Corfas G, Roy K, Buxbaum JD. 2004. Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat Neurosci 7(6):575-580.
7. Craddock N, O'Donovan MC, Owen MJ. 2006. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 32(1):9-16.
8. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. 2005. Efficiency and power in genetic association studies. Nat Genet 37(11):1217-1223.
9. Dudbridge F. 2003. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25(2):115-121.
10. Freedman R. 2003. Schizophrenia. N Engl J Med 349(18):1738-1749.
11. Fukada M, Kawachi H, Fujikawa A, Noda M. 2005. Yeast substrate-trapping system for isolating substrates of protein tyrosine phosphatases: Isolation of substrates for protein tyrosine phosphatase receptor type z. Methods 35(1):54-63.
12. Garwood J, Heck N, Reichardt F, Faissner A. 2003. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. J Biol Chem 278(26):24164-24173.
13. Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160(4):636-645.
14. Harrison PJ. 2007. Schizophrenia susceptibility genes and neurodevelopment. Biol Psychiatry 61(10):1119-1120.
15. Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, Buxbaum JD, Schlessinger J. 2002. A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions. Nat Genet 32(3):411-414.
16. Law AJ, Kleinman JE, Weinberger DR, Weickert CS. 2007. Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet 16(2):129-141.
17. Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM, Huang JT, Cannizzaro LA, Park SH, Druck T, Huebner K, Sap J, Ehrlich M, Musacchio JM, Schlessinger J. 1993. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. J Biol Chem 268(14):10573-10581.
18. Lewis DA, Levitt P. 2002. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 25:409-432.
19. Li D, Collier DA, He L. 2006. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet 15(12):1995-2002.
20. Li B, Woo RS, Mei L, Malinow R. 2007. The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Neuron 54(4):583-597.
21. Montgomery JM, Zamorano PL, Garner CC. 2004. MAGUKs in synapse assembly and function: An emerging view. Cell Mol Life Sci 61 (7-8):911-929.
22. Munafo MR, Thiselton DL, Clark TG, Flint J. 2006. Association of the NRG1 gene and schizophrenia: A meta-analysis. Mol Psychiatry 11(6):539-546.
23. Neale BM, Sham PC. 2004. The future of association studies: Gene-based analysis and replication. Am J Hum Genet 75(3):353-362.
24. Niisato K, Fujikawa A, Komai S, Shintani T, Watanabe E, Sakaguchi G, Katsuura G, Manabe T, Noda M. 2005. Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice. J Neurosci 25(5):1081-1088.
25. Norton N, Moskvina V, Morris DW, Bray NJ, Zammit S, Williams NM, Williams HJ, Preece AC, Dwyer S, Wilkinson JC, Spurlock G, Kirov G, Buckland P, Waddington JL, Gill M, Corvin AP, Owen MJ, O'Donovan MC. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. Am J Med Genet Part B 141B(1):96-101.
26. Nyholt DR. 2004. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74(4):765-769.
27. Paul S, Lombroso PJ. 2003. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci 60(11):2465-2482.
28. Purcell S, Cherny SS, Sham PC. 2003. Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19(1):149-150.
29. Rapoport JL, Addington AM, Frangou S, Psych MR. 2005. The neurodevelopmental model of schizophrenia: Update 2005. Mol Psychiatry 10(5):434-449.
30. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. 2006. Neurobiology of schizophrenia. Neuron 52(1):139-153.
31. Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, Albus M, Lerer B, Rietschel M, Trixler M, Maier W, Wildenauer DB. 2003. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet 72(1):185-190.
32. Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Beckmann JS, Yakir B, Risch N, Zak NB, Darvasi A. 2002. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 71(6):1296-1302.
33. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K. 2002. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71(4):877-892.
34. Tamura H, Fukada M, Fujikawa A, Noda M. 2006. Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP. Neurosci Lett 399(1-2):33-38.
35. Woo RS, Li XM, Tao Y, Carpenter-Hyland E, Huang YZ, Weber J, Neiswender H, Dong XP, Wu J, Gassmann M, Lai C, Xiong WC, Gao TM, Mei L. 2007. Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54(4):599-610.