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Volumn 15, Issue 4, 2008, Pages 352-358

Adult-onset growth hormone deficiency: Causes, complications and treatment options

Author keywords

Adult onset growth hormone deficiency; Growth hormone deficiency in adults; Growth hormone replacement therapy

Indexed keywords

APOLIPOPROTEIN E; BLOOD CLOTTING FACTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOCORTICOID; GROWTH HORMONE; HUMAN GROWTH HORMONE; LOW DENSITY LIPOPROTEIN RECEPTOR; SOMATOMEDIN C; THYROID HORMONE; VERY LOW DENSITY LIPOPROTEIN;

EID: 55249117519     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e3282ffd97d     Document Type: Review
Times cited : (13)

References (72)
  • 1
    • 34247351912 scopus 로고    scopus 로고
    • Hypopituitarism
    • A comprehensive review of hypopituitarism
    • Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, et al. Hypopituitarism. Lancet 2007; 369:1461-1470. A comprehensive review of hypopituitarism.
    • (2007) Lancet , vol.369 , pp. 1461-1470
    • Schneider, H.J.1    Aimaretti, G.2    Kreitschmann-Andermahr, I.3
  • 2
    • 33746316566 scopus 로고    scopus 로고
    • Incidence of GH deficiency - a nationwide study
    • Stochholm K, Gravholt C, Laursen T, et al. Incidence of GH deficiency - a nationwide study. Eur J Endocrinol 2006; 155:61-71.
    • (2006) Eur J Endocrinol , vol.155 , pp. 61-71
    • Stochholm, K.1    Gravholt, C.2    Laursen, T.3
  • 3
    • 0029863765 scopus 로고    scopus 로고
    • The effect of hypopituitarism on life expectancy
    • Bates AS, Hoff W, Vant J, et al. The effect of hypopituitarism on life expectancy. J Clinic Endocrinol Metab 1996; 81:1169-1172.
    • (1996) J Clinic Endocrinol Metab , vol.81 , pp. 1169-1172
    • Bates, A.S.1    Hoff, W.2    Vant, J.3
  • 4
    • 34748853927 scopus 로고    scopus 로고
    • Hypothalamopituitary dysfunction following traumatic brain injury and aneurismal subarachnoid hemorrhagic: A systematic review
    • A comprehensive review of hypothalamic dysfunction after TBI. This study shows that the mechanism and severity of the brain injury does, in fact, impact the severity of hormonal deficiencies
    • Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, et al. Hypothalamopituitary dysfunction following traumatic brain injury and aneurismal subarachnoid hemorrhagic: a systematic review. JAMA 2007; 298:1429-1438. A comprehensive review of hypothalamic dysfunction after TBI. This study shows that the mechanism and severity of the brain injury does, in fact, impact the severity of hormonal deficiencies.
    • (2007) JAMA , vol.298 , pp. 1429-1438
    • Schneider, H.J.1    Kreitschmann-Andermahr, I.2    Ghigo, E.3
  • 5
    • 34447503585 scopus 로고    scopus 로고
    • Prevalence and predictive factors of posttraumatic hypopituitarism
    • Oxf, This study showed that indicators of increased TBI severity were predictive of hypopituitarism, with a high negative predictive value
    • Klose M, Juul A, Poulsgaard L, et al. Prevalence and predictive factors of posttraumatic hypopituitarism. Clin Endocrinol (Oxf) 2007; 67:193-201. This study showed that indicators of increased TBI severity were predictive of hypopituitarism, with a high negative predictive value.
    • (2007) Clin Endocrinol , vol.67 , pp. 193-201
    • Klose, M.1    Juul, A.2    Poulsgaard, L.3
  • 7
    • 40949118610 scopus 로고    scopus 로고
    • Endocrine consequences of adult traumatic brain injury
    • Behan LA, Agha A. Endocrine consequences of adult traumatic brain injury. Horm Res 2007; 68 (Suppl 5):18-21.
    • (2007) Horm Res , vol.68 , Issue.SUPPL. 5 , pp. 18-21
    • Behan, L.A.1    Agha, A.2
  • 8
    • 28744436684 scopus 로고    scopus 로고
    • Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults
    • Agha A, Sherlock M, Brennan S, et al. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab 2005; 90:6355-6360.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6355-6360
    • Agha, A.1    Sherlock, M.2    Brennan, S.3
  • 9
    • 33750262583 scopus 로고    scopus 로고
    • Endocrine dysfunction in patients operated on for nonpituitary intracranial tumors
    • Schneider HJ, Rovere S, Corneli G, et al. Endocrine dysfunction in patients operated on for nonpituitary intracranial tumors. Eur J Endocrinol 2006; 155:559-566.
    • (2006) Eur J Endocrinol , vol.155 , pp. 559-566
    • Schneider, H.J.1    Rovere, S.2    Corneli, G.3
  • 10
    • 33749556014 scopus 로고    scopus 로고
    • Predictive value of circulating insulin-like growth factor I levels in ischemic stroke outcome
    • Bondanelli M, Ambrosio MR, Onofri A, et al. Predictive value of circulating insulin-like growth factor I levels in ischemic stroke outcome. J Clin Endocrinol Metab 2006; 91:3928-3934.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3928-3934
    • Bondanelli, M.1    Ambrosio, M.R.2    Onofri, A.3
  • 11
    • 33646402056 scopus 로고    scopus 로고
    • Endocrine Society's Clinical Guidelines Subcommittee. Evaluation and treatment of adult growth hormone deficiency: An Endocrine Society Clinical Practice Guideline
    • Molitch ME, Clemmons DR, Malozowski S, et al., Endocrine Society's Clinical Guidelines Subcommittee. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2006; 91:1621-1634.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1621-1634
    • Molitch, M.E.1    Clemmons, D.R.2    Malozowski, S.3
  • 12
    • 40949155904 scopus 로고    scopus 로고
    • Stochholm K, Christiansen J, Laursen T, Gravholt CH. Mortality and reduced growth hormone secretion. Horm Res 2007; 68 (Suppl 5):173-176. A perspective article calling for further research to provide more reliable estimates of actual causes of death in GHD patients.
    • Stochholm K, Christiansen J, Laursen T, Gravholt CH. Mortality and reduced growth hormone secretion. Horm Res 2007; 68 (Suppl 5):173-176. A perspective article calling for further research to provide more reliable estimates of actual causes of death in GHD patients.
  • 13
    • 34547425394 scopus 로고    scopus 로고
    • Mortality and GH deficiency: A nationwide study
    • This paper describes one of a very few studies looking at mortality rates in GHD patients. Patients are divided into childhood and adult-onset, and mortality is listed by cause
    • Stochholm K, Gravholt CH, Laursen T, et al. Mortality and GH deficiency: a nationwide study. Eur J Endocrinol 2007; 157:9-18. This paper describes one of a very few studies looking at mortality rates in GHD patients. Patients are divided into childhood and adult-onset, and mortality is listed by cause.
    • (2007) Eur J Endocrinol , vol.157 , pp. 9-18
    • Stochholm, K.1    Gravholt, C.H.2    Laursen, T.3
  • 14
    • 34548858200 scopus 로고    scopus 로고
    • Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone
    • A retrospective study looking at the prevalence of cerebrovascular and cardiovascular morbidity, and diabetes in patients receiving GHRT. This study provides much-needed data on cardiovascular morbidity in this patient population
    • Holmer H, Svensson J, Rylander L, et al. Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone. J Clin Endocrinol Metab 2007; 92:3560-3567. A retrospective study looking at the prevalence of cerebrovascular and cardiovascular morbidity, and diabetes in patients receiving GHRT. This study provides much-needed data on cardiovascular morbidity in this patient population.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3560-3567
    • Holmer, H.1    Svensson, J.2    Rylander, L.3
  • 15
    • 34247556914 scopus 로고    scopus 로고
    • The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH
    • An important negative study showing that overall GHRT does not have an effect on components of the metabolic syndrome
    • van der Klaauw AA, Biermasz NR, Feskens EJ, et al. The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH. Eur J Endocrinol 2007; 156:455-462. An important negative study showing that overall GHRT does not have an effect on components of the metabolic syndrome.
    • (2007) Eur J Endocrinol , vol.156 , pp. 455-462
    • van der Klaauw, A.A.1    Biermasz, N.R.2    Feskens, E.J.3
  • 16
    • 34548141859 scopus 로고    scopus 로고
    • Evidence for distinct effects of GH and IGF-I in the metabolic syndrome
    • This study shows a positive correlation between IGF-1 and lipids, and a negative correlation with obesity. Sex difference is observed with IGF-1 significantly lower in women with the metabolic syndrome
    • Maison P, Balkau B, Souberbielle JC, et al. Evidence for distinct effects of GH and IGF-I in the metabolic syndrome. Diabet Med 2007; 24:1012-1018. This study shows a positive correlation between IGF-1 and lipids, and a negative correlation with obesity. Sex difference is observed with IGF-1 significantly lower in women with the metabolic syndrome.
    • (2007) Diabet Med , vol.24 , pp. 1012-1018
    • Maison, P.1    Balkau, B.2    Souberbielle, J.C.3
  • 17
    • 33750502242 scopus 로고    scopus 로고
    • Effect of growth hormone treatment on trunk fat accumulation in adult GH-deficient Japanese patients: A randomized, placebo-controlled trial
    • Chihara K, Kato Y, Takano K, et al. Effect of growth hormone treatment on trunk fat accumulation in adult GH-deficient Japanese patients: a randomized, placebo-controlled trial. Curr Med Res Opin 2006; 22:1973-1979.
    • (2006) Curr Med Res Opin , vol.22 , pp. 1973-1979
    • Chihara, K.1    Kato, Y.2    Takano, K.3
  • 18
    • 34147126350 scopus 로고    scopus 로고
    • A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults
    • The longest prospective study looking at outcome measures with GHRT. It shows a sustained improvement in body composition and lipid profile, with more marked body composition changes in men
    • Götherström G, Bengtsson BA, Bosaeus I, et al. A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults. J Clin Endocrinol Metab 2007; 92:1442-1445. The longest prospective study looking at outcome measures with GHRT. It shows a sustained improvement in body composition and lipid profile, with more marked body composition changes in men.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1442-1445
    • Götherström, G.1    Bengtsson, B.A.2    Bosaeus, I.3
  • 19
    • 36849045260 scopus 로고    scopus 로고
    • Oliveira JL, Aguiar-Oliveira MH, D'Oliveira A Jr, et al. Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naïve adults. J Clin Endocrinol Metab 2007; 92:4664-4670. This study on congenital GH-deficient patients showed an increase in the number of atherosclerotic plaques in patients receiving GHRT, suggesting a word of caution on the universally accepted beneficial effects of GHRT on atherosclerosis.
    • Oliveira JL, Aguiar-Oliveira MH, D'Oliveira A Jr, et al. Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naïve adults. J Clin Endocrinol Metab 2007; 92:4664-4670. This study on congenital GH-deficient patients showed an increase in the number of atherosclerotic plaques in patients receiving GHRT, suggesting a word of caution on the universally accepted beneficial effects of GHRT on atherosclerosis.
  • 20
    • 35948943202 scopus 로고    scopus 로고
    • Management of growth hormone deficiency in adults
    • A comprehensive review on the management of GHD in adults
    • Nilsson AG, Svensson J, Johannsson G. Management of growth hormone deficiency in adults. Growth Horm IGF Res 2007; 17:441-462. A comprehensive review on the management of GHD in adults.
    • (2007) Growth Horm IGF Res , vol.17 , pp. 441-462
    • Nilsson, A.G.1    Svensson, J.2    Johannsson, G.3
  • 21
    • 2442526224 scopus 로고    scopus 로고
    • Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: A metaanalysis of blinded, randomized, placebo-controlled trials
    • Maison P, Griffin S, Nicoue-Beglah M, et al. Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a metaanalysis of blinded, randomized, placebo-controlled trials. J Clin Endocrinol Metab 2004; 89:2192-2199.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2192-2199
    • Maison, P.1    Griffin, S.2    Nicoue-Beglah, M.3
  • 22
    • 34548763034 scopus 로고    scopus 로고
    • Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy
    • Monson JP, Jönsson P, Koltowska-Häggström M, Kourides I. Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy. Clin Endocrinol (Oxf) 2007; 67:623-628.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 623-628
    • Monson, J.P.1    Jönsson, P.2    Koltowska-Häggström, M.3    Kourides, I.4
  • 23
    • 33947415737 scopus 로고    scopus 로고
    • Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency
    • Takahashi Y, Iida K, Takahashi K, et al. Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency. Gastroenterology 2007; 132:938-943.
    • (2007) Gastroenterology , vol.132 , pp. 938-943
    • Takahashi, Y.1    Iida, K.2    Takahashi, K.3
  • 24
    • 34147115747 scopus 로고    scopus 로고
    • Atherogenic lipoprotein phenotype and low-density lipoprotein size and subclasses in patients with growth hormone deficiency before and after short-term replacement therapy
    • Rizzo M, Trepp R, Berneis K, Christ ER. Atherogenic lipoprotein phenotype and low-density lipoprotein size and subclasses in patients with growth hormone deficiency before and after short-term replacement therapy. Eur J Endocrinol 2007; 156:361-367.
    • (2007) Eur J Endocrinol , vol.156 , pp. 361-367
    • Rizzo, M.1    Trepp, R.2    Berneis, K.3    Christ, E.R.4
  • 25
    • 35348812759 scopus 로고    scopus 로고
    • Who needs to care about small, dense low-density lipoproteins?
    • Rizzo M, Berneis K. Who needs to care about small, dense low-density lipoproteins? Int J Clin Pract 2007; 61:1949-1956.
    • (2007) Int J Clin Pract , vol.61 , pp. 1949-1956
    • Rizzo, M.1    Berneis, K.2
  • 26
    • 41649104293 scopus 로고    scopus 로고
    • Postprandial alterations in LDL size and subclasses in patients with growth hormone deficiency
    • Rizzo M, Trepp R, Berneis K, Christ ER. Postprandial alterations in LDL size and subclasses in patients with growth hormone deficiency. Growth Horm IGF Res 2008; 18:264-266.
    • (2008) Growth Horm IGF Res , vol.18 , pp. 264-266
    • Rizzo, M.1    Trepp, R.2    Berneis, K.3    Christ, E.R.4
  • 27
    • 2542466624 scopus 로고    scopus 로고
    • Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals
    • Randeva HS, Lewandowski KC, Komorowski J, et al. Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals. Circulation 2004; 109:2405-2410.
    • (2004) Circulation , vol.109 , pp. 2405-2410
    • Randeva, H.S.1    Lewandowski, K.C.2    Komorowski, J.3
  • 28
    • 33646865444 scopus 로고    scopus 로고
    • Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with growth hormone deficiency
    • Gómez JM, Sahún M, Vila R, et al. Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with growth hormone deficiency. Clin Endocrinol (Oxf) 2006; 64:632-639.
    • (2006) Clin Endocrinol (Oxf) , vol.64 , pp. 632-639
    • Gómez, J.M.1    Sahún, M.2    Vila, R.3
  • 29
    • 33847122639 scopus 로고    scopus 로고
    • Elevation of E-selectin concentrations may correlate with potential endothelial dysfunction in individuals with hypopituitarism during therapy with growth hormone
    • Gómez JM, Sahún M, Vila R, et al. Elevation of E-selectin concentrations may correlate with potential endothelial dysfunction in individuals with hypopituitarism during therapy with growth hormone. Curr Neurovasc Res 2007; 4:55-62.
    • (2007) Curr Neurovasc Res , vol.4 , pp. 55-62
    • Gómez, J.M.1    Sahún, M.2    Vila, R.3
  • 30
    • 33947264873 scopus 로고    scopus 로고
    • Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency
    • Oflaz H, Sen F, Elitok A, et al. Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency. Clin Endocrinol (Oxf) 2007; 66:524-529.
    • (2007) Clin Endocrinol (Oxf) , vol.66 , pp. 524-529
    • Oflaz, H.1    Sen, F.2    Elitok, A.3
  • 31
    • 34047157587 scopus 로고    scopus 로고
    • Obese adults with primary growth hormone resistance (Laron Syndrome) have normal endothelial function
    • Schechter M, Ginsberg S, Sheinowitz M, et al. Obese adults with primary growth hormone resistance (Laron Syndrome) have normal endothelial function. Growth Horm IGF Res 2007; 17:165-170.
    • (2007) Growth Horm IGF Res , vol.17 , pp. 165-170
    • Schechter, M.1    Ginsberg, S.2    Sheinowitz, M.3
  • 32
    • 42049086543 scopus 로고    scopus 로고
    • Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I
    • This study demonstrates that the effects of GH on endothelial function occur independently of IGF-1
    • Li G, Del Rincon JP, Jahn LA, et al. Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I. J Clin Endocrinol Metab 2008; 93:1379-1385. This study demonstrates that the effects of GH on endothelial function occur independently of IGF-1.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1379-1385
    • Li, G.1    Del Rincon, J.P.2    Jahn, L.A.3
  • 33
    • 33847039083 scopus 로고    scopus 로고
    • Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulinlike growth-factor-1
    • Thum T, Hoeber S, Froese S, et al. Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulinlike growth-factor-1. Circ Res 2007; 100:434-443.
    • (2007) Circ Res , vol.100 , pp. 434-443
    • Thum, T.1    Hoeber, S.2    Froese, S.3
  • 34
    • 0043246591 scopus 로고    scopus 로고
    • Increased Interleukin-6 levels in pituitary-deficient patients are independently related to their carotid intima-media thickness
    • Leonsson M, Hulthe J, Johannsson G, et al. Increased Interleukin-6 levels in pituitary-deficient patients are independently related to their carotid intima-media thickness. Clin Endocrinol (Oxf) 2003; 59:242-250.
    • (2003) Clin Endocrinol (Oxf) , vol.59 , pp. 242-250
    • Leonsson, M.1    Hulthe, J.2    Johannsson, G.3
  • 35
    • 0034682622 scopus 로고    scopus 로고
    • Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial
    • Sesmilo G, Biller BM, Llevadot J, et al. Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial. Ann Inten Med 2000; 133:111-122.
    • (2000) Ann Inten Med , vol.133 , pp. 111-122
    • Sesmilo, G.1    Biller, B.M.2    Llevadot, J.3
  • 36
    • 36248956034 scopus 로고    scopus 로고
    • Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment of patients with acromegaly and growth hormone deficiency
    • Andreassen M, Vestergaard H, Kristensen LØ. Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment of patients with acromegaly and growth hormone deficiency. Clin Endocrinol (Oxf) 2007; 67:909-916.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 909-916
    • Andreassen, M.1    Vestergaard, H.2    Kristensen, L.3
  • 37
    • 33646026112 scopus 로고    scopus 로고
    • Positive effects of a physiological dose of GH on markers of atherogenesis: A placebo-controlled study in patients with adult-onset GH deficiency
    • Bollerslev J, Ueland T, Jørgensen AP, et al. Positive effects of a physiological dose of GH on markers of atherogenesis: a placebo-controlled study in patients with adult-onset GH deficiency. Eur J Endocrinol 2006; 154: 537-543.
    • (2006) Eur J Endocrinol , vol.154 , pp. 537-543
    • Bollerslev, J.1    Ueland, T.2    Jørgensen, A.P.3
  • 38
    • 33746370734 scopus 로고    scopus 로고
    • Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis
    • Abs R, Feldt-Rasmussen U, Mattsson AF, et al. Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis. Eur J Endocrinol 2006; 155:79-90.
    • (2006) Eur J Endocrinol , vol.155 , pp. 79-90
    • Abs, R.1    Feldt-Rasmussen, U.2    Mattsson, A.F.3
  • 39
    • 34548794192 scopus 로고    scopus 로고
    • Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency
    • A prospective study showing alterations in fibrinolysis in GHD patients, suggesting a possible mechanism for increased cardiovascular morbidity
    • Devin JK, Blevins LS Jr, Verity DK, et al. Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. J Clin Endocrinol Metab 2007; 92:3633-3639. A prospective study showing alterations in fibrinolysis in GHD patients, suggesting a possible mechanism for increased cardiovascular morbidity.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3633-3639
    • Devin, J.K.1    Blevins Jr, L.S.2    Verity, D.K.3
  • 40
    • 33750630132 scopus 로고    scopus 로고
    • Changes in prothrombin and activated partial thromboplastin time during replacement with human recombinant growth hormone in growth hormone deficient adults
    • Athens
    • Miljic D, Miljic P, Doknic M, et al. Changes in prothrombin and activated partial thromboplastin time during replacement with human recombinant growth hormone in growth hormone deficient adults. Hormones (Athens) 2006;
    • (2006) Hormones
    • Miljic, D.1    Miljic, P.2    Doknic, M.3
  • 41
    • 34250155671 scopus 로고    scopus 로고
    • Pharmacologic therapy in growth hormone disorders and the heart
    • A thorough review of cardiac function in patients with GHD and the effects of GHRT on cardiac function
    • Climent V, Marín F, Picó A. Pharmacologic therapy in growth hormone disorders and the heart. Curr Med Chem 2007; 14:1399-1407. A thorough review of cardiac function in patients with GHD and the effects of GHRT on cardiac function.
    • (2007) Curr Med Chem , vol.14 , pp. 1399-1407
    • Climent, V.1    Marín, F.2    Picó, A.3
  • 42
    • 38349047822 scopus 로고    scopus 로고
    • Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity
    • Hartman ML, Weltman A, Zagar A, et al. Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity. J Clin Endocrinol Metab 2008; 93:125-130.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 125-130
    • Hartman, M.L.1    Weltman, A.2    Zagar, A.3
  • 43
    • 0034751043 scopus 로고    scopus 로고
    • Baseline characteristics and the effects of five years ofGHreplacement therapy in adults with GH deficiency of childhood or adulthood onset: A comparative, prospective study
    • Koranyi J, Svensson J, Götherström G, et al. Baseline characteristics and the effects of five years ofGHreplacement therapy in adults with GH deficiency of childhood or adulthood onset: a comparative, prospective study. J Clin Endocrinol Metab 2001; 86:4693-4699.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4693-4699
    • Koranyi, J.1    Svensson, J.2    Götherström, G.3
  • 44
    • 37349017937 scopus 로고    scopus 로고
    • Bone quality: The material and structural basis of bone strength
    • Seeman E. Bone quality: the material and structural basis of bone strength. J Bone Miner Metab 2008; 26:1-8.
    • (2008) J Bone Miner Metab , vol.26 , pp. 1-8
    • Seeman, E.1
  • 45
    • 34249825222 scopus 로고    scopus 로고
    • Khosla S, Melton LJ 3rd. Clinical practice. Osteopenia. N Eng J Med 2007; 356:2293-2300.
    • Khosla S, Melton LJ 3rd. Clinical practice. Osteopenia. N Eng J Med 2007; 356:2293-2300.
  • 46
    • 38649139894 scopus 로고    scopus 로고
    • Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency
    • Mazziotti G, Bianchi A, Cimino V, et al. Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency. Pituitary 2008; 11:55-61.
    • (2008) Pituitary , vol.11 , pp. 55-61
    • Mazziotti, G.1    Bianchi, A.2    Cimino, V.3
  • 47
    • 33751174502 scopus 로고    scopus 로고
    • Bone mineral density in patients with growth hormone deficiency: Does a gender difference exist?
    • Hitz MF, Jensen JE, Eskildsen PC. Bone mineral density in patients with growth hormone deficiency: does a gender difference exist? Clin Endocrinol (Oxf) 2006; 65:783-791.
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 783-791
    • Hitz, M.F.1    Jensen, J.E.2    Eskildsen, P.C.3
  • 48
    • 34447500560 scopus 로고    scopus 로고
    • Effect of growth hormone replacement on BMD in adult-onset growth hormone deficiency
    • This paper describes one of the few randomized controlled trials that look at the effect of GHRT on BMD
    • Snyder PJ, Biller BM, Zagar A, et al. Effect of growth hormone replacement on BMD in adult-onset growth hormone deficiency. J Bone Miner Res 2007; 22:762-770. This paper describes one of the few randomized controlled trials that look at the effect of GHRT on BMD.
    • (2007) J Bone Miner Res , vol.22 , pp. 762-770
    • Snyder, P.J.1    Biller, B.M.2    Zagar, A.3
  • 49
    • 38749152098 scopus 로고    scopus 로고
    • Fracture incidence in GH-deficient patients on complete hormone replacement including GH
    • Holmer H, Svensson J, Rylander L, et al. Fracture incidence in GH-deficient patients on complete hormone replacement including GH. J Bone Miner Res 2007; 22:1842-1850.
    • (2007) J Bone Miner Res , vol.22 , pp. 1842-1850
    • Holmer, H.1    Svensson, J.2    Rylander, L.3
  • 50
    • 33645330427 scopus 로고    scopus 로고
    • Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: Influence of GH replacement therapy
    • Mazziotti G, Bianchi A, Bonadonna S, et al. Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy. J Bone Miner Res 2006; 21:520-528.
    • (2006) J Bone Miner Res , vol.21 , pp. 520-528
    • Mazziotti, G.1    Bianchi, A.2    Bonadonna, S.3
  • 51
    • 34250700992 scopus 로고    scopus 로고
    • Heterogeneity in responsiveness of perceived quality of life to body composition changes between adult- and childhood-onset Japanese hypopituitary adults with GH deficiency during GH replacement
    • Urushihara H, Fukuhara S, Tai S, et al. Heterogeneity in responsiveness of perceived quality of life to body composition changes between adult- and childhood-onset Japanese hypopituitary adults with GH deficiency during GH replacement. Eur J Endocrinol 2007; 156:637-645.
    • (2007) Eur J Endocrinol , vol.156 , pp. 637-645
    • Urushihara, H.1    Fukuhara, S.2    Tai, S.3
  • 52
    • 32544450628 scopus 로고    scopus 로고
    • The effects of growth hormone and/or testosterone in healthy elderly men: A randomized controlled trial
    • Giannoulis MG, Sonksen PH, Umpleby M, et al. The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial. J Clin Endocrinol Metab 2006; 91:477-484.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 477-484
    • Giannoulis, M.G.1    Sonksen, P.H.2    Umpleby, M.3
  • 53
    • 0141616469 scopus 로고    scopus 로고
    • Psychological effects of withdrawal of growth hormone replacement therapy from adults with growth hormone deficiency
    • McMillan CV, Bradley C, Gibney J, et al. Psychological effects of withdrawal of growth hormone replacement therapy from adults with growth hormone deficiency. Clin Endocrinol (Oxf) 2003; 59:467-475.
    • (2003) Clin Endocrinol (Oxf) , vol.59 , pp. 467-475
    • McMillan, C.V.1    Bradley, C.2    Gibney, J.3
  • 54
    • 0037464931 scopus 로고    scopus 로고
    • Growth hormone deficiency in adults: Effects of replacement therapy on body composition and health-related quality of life
    • Mesa J, Gomez JM, Hernandez C, et al. Growth hormone deficiency in adults: effects of replacement therapy on body composition and health-related quality of life. Med Clin (Barc) 2003; 120:41-46.
    • (2003) Med Clin (Barc) , vol.120 , pp. 41-46
    • Mesa, J.1    Gomez, J.M.2    Hernandez, C.3
  • 55
    • 0036051333 scopus 로고    scopus 로고
    • The effect of long-term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life of GH-deficient adults
    • Gilchrist FJ, Murray RD, Shalet SM. The effect of long-term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life of GH-deficient adults. Clin Endocrinol (Oxf) 2002; 57:363-370.
    • (2002) Clin Endocrinol (Oxf) , vol.57 , pp. 363-370
    • Gilchrist, F.J.1    Murray, R.D.2    Shalet, S.M.3
  • 56
    • 34247607635 scopus 로고    scopus 로고
    • Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: A placebo-controlled 12-month study
    • Sathiavageeswaran M, Burman P, Lawrence D, et al. Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study. Eur J Endocrinol 2007; 156:439-447.
    • (2007) Eur J Endocrinol , vol.156 , pp. 439-447
    • Sathiavageeswaran, M.1    Burman, P.2    Lawrence, D.3
  • 57
    • 33745016644 scopus 로고    scopus 로고
    • Effects of growth hormone substitution therapy on cognitive functioning in growth hormone deficient patients: A functional MRI study
    • Arwert LI, Veltman DJ, Deijen JB, et al. Effects of growth hormone substitution therapy on cognitive functioning in growth hormone deficient patients: a functional MRI study. Neuroendocrinology 2006; 83:12-19.
    • (2006) Neuroendocrinology , vol.83 , pp. 12-19
    • Arwert, L.I.1    Veltman, D.J.2    Deijen, J.B.3
  • 58
    • 33747662304 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and pharmacodynamics of a new sustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency
    • Bidlingmaier M, Kim J, Savoy C, et al. Comparative pharmacokinetics and pharmacodynamics of a new sustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency. J Clin Endocrinol Metab 2006; 91:2926-2930.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2926-2930
    • Bidlingmaier, M.1    Kim, J.2    Savoy, C.3
  • 59
    • 33847282323 scopus 로고    scopus 로고
    • Growth hormone (GH) replacement therapy in GH deficient adults: Predictors of one-year metabolic and clinical response
    • Svensson J, Finer N, Bouloux P, et al. Growth hormone (GH) replacement therapy in GH deficient adults: predictors of one-year metabolic and clinical response. Growth Horm IGF Res 2007; 17:67-76.
    • (2007) Growth Horm IGF Res , vol.17 , pp. 67-76
    • Svensson, J.1    Finer, N.2    Bouloux, P.3
  • 60
    • 34249896940 scopus 로고    scopus 로고
    • IGF-I measurements in the monitoring of GH therapy
    • Higham CE, Jostel A, Trainer PJ. IGF-I measurements in the monitoring of GH therapy. Pituitary 2007; 10:159-163.
    • (2007) Pituitary , vol.10 , pp. 159-163
    • Higham, C.E.1    Jostel, A.2    Trainer, P.J.3
  • 61
    • 38349050260 scopus 로고    scopus 로고
    • GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: A statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia
    • A succinct, practical guide to the approach of patients with adult-onset GHD
    • Ho KK, 2007 GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol 2007; 157:695-700. A succinct, practical guide to the approach of patients with adult-onset GHD.
    • (2007) Eur J Endocrinol 2007 , vol.157 , pp. 695-700
    • Ho, K.K.1
  • 62
    • 34547795679 scopus 로고    scopus 로고
    • Influence of GH substitution therapy in deficient adults on the recurrence rate of hormonally inactive pituitary adenomas: A case control study
    • Buchfelder M, Kann PH, Wüster C, et al. Influence of GH substitution therapy in deficient adults on the recurrence rate of hormonally inactive pituitary adenomas: a case control study. Eur J Endocrinol 2007; 157:149-156.
    • (2007) Eur J Endocrinol , vol.157 , pp. 149-156
    • Buchfelder, M.1    Kann, P.H.2    Wüster, C.3
  • 63
    • 67649974624 scopus 로고    scopus 로고
    • Stanley TL, Grinspoon SK. GH/GHRH axis in HIV lipodystrophy. Pituitary 2008 [Epub ahead of print].
    • Stanley TL, Grinspoon SK. GH/GHRH axis in HIV lipodystrophy. Pituitary 2008 [Epub ahead of print].
  • 64
    • 37349034238 scopus 로고    scopus 로고
    • Role of recombinant human growth hormone in HIV-associated wasting and cachexia: Pathophysiology and rationale for treatment
    • Gelato M, McNurlan M, Freedland E. Role of recombinant human growth hormone in HIV-associated wasting and cachexia: pathophysiology and rationale for treatment. Clin Ther 2007; 29:2269-2288.
    • (2007) Clin Ther , vol.29 , pp. 2269-2288
    • Gelato, M.1    McNurlan, M.2    Freedland, E.3
  • 65
    • 36849058739 scopus 로고    scopus 로고
    • Metabolic effects of a growth hormone-releasing factor in patients with HIV
    • Falutz J, Allas S, Blot K, et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med 2007; 357:2359-2370.
    • (2007) N Engl J Med , vol.357 , pp. 2359-2370
    • Falutz, J.1    Allas, S.2    Blot, K.3
  • 66
    • 36849007004 scopus 로고    scopus 로고
    • Manipulation of the growth hormone axis in patients with HIV infection
    • Blackman MR. Manipulation of the growth hormone axis in patients with HIV infection. N Engl J Med 2007; 357:2397-2399.
    • (2007) N Engl J Med , vol.357 , pp. 2397-2399
    • Blackman, M.R.1
  • 67
    • 33747333574 scopus 로고    scopus 로고
    • Growth hormone secretion is impaired in amyotrophic lateral sclerosis
    • Morselli LL, Bongioanni P, Genovesi M, et al. Growth hormone secretion is impaired in amyotrophic lateral sclerosis. Clin Endocrinol (Oxf) 2006; 65: 385-388.
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 385-388
    • Morselli, L.L.1    Bongioanni, P.2    Genovesi, M.3
  • 68
    • 36949017756 scopus 로고    scopus 로고
    • Impairment of GH secretion in amyotrophic lateral sclerosis is not affected by riluzole treatment
    • Morselli LL, Bongioanni P, Genovesi M, et al. Impairment of GH secretion in amyotrophic lateral sclerosis is not affected by riluzole treatment. J Endocrinol Invest 2007; 30:767-770.
    • (2007) J Endocrinol Invest , vol.30 , pp. 767-770
    • Morselli, L.L.1    Bongioanni, P.2    Genovesi, M.3
  • 69
    • 31844450693 scopus 로고    scopus 로고
    • Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: Insights into the regulation of adult hippocampal neurogenesis
    • Lichtenwalner RJ, Forbes ME, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis. J Neurosci Res 2006; 83:199-210.
    • (2006) J Neurosci Res , vol.83 , pp. 199-210
    • Lichtenwalner, R.J.1    Forbes, M.E.2    Sonntag, W.E.3    Riddle, D.R.4
  • 70
    • 35448988906 scopus 로고    scopus 로고
    • Growth hormone deficiency (GHD) in adult thalassemic patients
    • Scacchi M, Danesi L, Cattaneo A, et al. Growth hormone deficiency (GHD) in adult thalassemic patients. Clin Endocrinol (Oxf) 2007; 67:790-795.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 790-795
    • Scacchi, M.1    Danesi, L.2    Cattaneo, A.3
  • 71
    • 58149524781 scopus 로고    scopus 로고
    • Bone demineralization in adult thalassaemic patients. Contribution of growth hormone and insulin-like growth factor I at different skeletal sites
    • Oxf, Epub ahead of print
    • Scacchi M, Danesi L, Cattaneo A, et al. Bone demineralization in adult thalassaemic patients. Contribution of growth hormone and insulin-like growth factor I at different skeletal sites. Clin Endocrinol (Oxf). 2008 [Epub ahead of print].
    • (2008) Clin Endocrinol
    • Scacchi, M.1    Danesi, L.2    Cattaneo, A.3
  • 72
    • 33847734017 scopus 로고    scopus 로고
    • Cardiovascular risk in patients with growth hormone deficiency: Effects of growth hormone substitution
    • Burger AG, Monson JP, Colao AM, Klibanski A. Cardiovascular risk in patients with growth hormone deficiency: effects of growth hormone substitution. Endocr Pract 2006; 12:682-689.
    • (2006) Endocr Pract , vol.12 , pp. 682-689
    • Burger, A.G.1    Monson, J.P.2    Colao, A.M.3    Klibanski, A.4


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