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1
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34247351912
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Hypopituitarism
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A comprehensive review of hypopituitarism
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Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, et al. Hypopituitarism. Lancet 2007; 369:1461-1470. A comprehensive review of hypopituitarism.
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(2007)
Lancet
, vol.369
, pp. 1461-1470
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Schneider, H.J.1
Aimaretti, G.2
Kreitschmann-Andermahr, I.3
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3
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0029863765
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The effect of hypopituitarism on life expectancy
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Bates AS, Hoff W, Vant J, et al. The effect of hypopituitarism on life expectancy. J Clinic Endocrinol Metab 1996; 81:1169-1172.
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(1996)
J Clinic Endocrinol Metab
, vol.81
, pp. 1169-1172
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Bates, A.S.1
Hoff, W.2
Vant, J.3
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4
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34748853927
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Hypothalamopituitary dysfunction following traumatic brain injury and aneurismal subarachnoid hemorrhagic: A systematic review
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A comprehensive review of hypothalamic dysfunction after TBI. This study shows that the mechanism and severity of the brain injury does, in fact, impact the severity of hormonal deficiencies
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Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, et al. Hypothalamopituitary dysfunction following traumatic brain injury and aneurismal subarachnoid hemorrhagic: a systematic review. JAMA 2007; 298:1429-1438. A comprehensive review of hypothalamic dysfunction after TBI. This study shows that the mechanism and severity of the brain injury does, in fact, impact the severity of hormonal deficiencies.
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(2007)
JAMA
, vol.298
, pp. 1429-1438
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Schneider, H.J.1
Kreitschmann-Andermahr, I.2
Ghigo, E.3
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5
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34447503585
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Prevalence and predictive factors of posttraumatic hypopituitarism
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Oxf, This study showed that indicators of increased TBI severity were predictive of hypopituitarism, with a high negative predictive value
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Klose M, Juul A, Poulsgaard L, et al. Prevalence and predictive factors of posttraumatic hypopituitarism. Clin Endocrinol (Oxf) 2007; 67:193-201. This study showed that indicators of increased TBI severity were predictive of hypopituitarism, with a high negative predictive value.
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(2007)
Clin Endocrinol
, vol.67
, pp. 193-201
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Klose, M.1
Juul, A.2
Poulsgaard, L.3
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7
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40949118610
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Endocrine consequences of adult traumatic brain injury
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Behan LA, Agha A. Endocrine consequences of adult traumatic brain injury. Horm Res 2007; 68 (Suppl 5):18-21.
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(2007)
Horm Res
, vol.68
, Issue.SUPPL. 5
, pp. 18-21
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Behan, L.A.1
Agha, A.2
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8
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28744436684
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Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults
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Agha A, Sherlock M, Brennan S, et al. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab 2005; 90:6355-6360.
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(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 6355-6360
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Agha, A.1
Sherlock, M.2
Brennan, S.3
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9
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33750262583
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Endocrine dysfunction in patients operated on for nonpituitary intracranial tumors
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Schneider HJ, Rovere S, Corneli G, et al. Endocrine dysfunction in patients operated on for nonpituitary intracranial tumors. Eur J Endocrinol 2006; 155:559-566.
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(2006)
Eur J Endocrinol
, vol.155
, pp. 559-566
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Schneider, H.J.1
Rovere, S.2
Corneli, G.3
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10
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33749556014
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Predictive value of circulating insulin-like growth factor I levels in ischemic stroke outcome
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Bondanelli M, Ambrosio MR, Onofri A, et al. Predictive value of circulating insulin-like growth factor I levels in ischemic stroke outcome. J Clin Endocrinol Metab 2006; 91:3928-3934.
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(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 3928-3934
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Bondanelli, M.1
Ambrosio, M.R.2
Onofri, A.3
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11
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33646402056
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Endocrine Society's Clinical Guidelines Subcommittee. Evaluation and treatment of adult growth hormone deficiency: An Endocrine Society Clinical Practice Guideline
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Molitch ME, Clemmons DR, Malozowski S, et al., Endocrine Society's Clinical Guidelines Subcommittee. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2006; 91:1621-1634.
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(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 1621-1634
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Molitch, M.E.1
Clemmons, D.R.2
Malozowski, S.3
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12
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40949155904
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Stochholm K, Christiansen J, Laursen T, Gravholt CH. Mortality and reduced growth hormone secretion. Horm Res 2007; 68 (Suppl 5):173-176. A perspective article calling for further research to provide more reliable estimates of actual causes of death in GHD patients.
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Stochholm K, Christiansen J, Laursen T, Gravholt CH. Mortality and reduced growth hormone secretion. Horm Res 2007; 68 (Suppl 5):173-176. A perspective article calling for further research to provide more reliable estimates of actual causes of death in GHD patients.
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13
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34547425394
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Mortality and GH deficiency: A nationwide study
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This paper describes one of a very few studies looking at mortality rates in GHD patients. Patients are divided into childhood and adult-onset, and mortality is listed by cause
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Stochholm K, Gravholt CH, Laursen T, et al. Mortality and GH deficiency: a nationwide study. Eur J Endocrinol 2007; 157:9-18. This paper describes one of a very few studies looking at mortality rates in GHD patients. Patients are divided into childhood and adult-onset, and mortality is listed by cause.
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(2007)
Eur J Endocrinol
, vol.157
, pp. 9-18
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Stochholm, K.1
Gravholt, C.H.2
Laursen, T.3
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14
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34548858200
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Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone
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A retrospective study looking at the prevalence of cerebrovascular and cardiovascular morbidity, and diabetes in patients receiving GHRT. This study provides much-needed data on cardiovascular morbidity in this patient population
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Holmer H, Svensson J, Rylander L, et al. Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone. J Clin Endocrinol Metab 2007; 92:3560-3567. A retrospective study looking at the prevalence of cerebrovascular and cardiovascular morbidity, and diabetes in patients receiving GHRT. This study provides much-needed data on cardiovascular morbidity in this patient population.
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(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 3560-3567
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Holmer, H.1
Svensson, J.2
Rylander, L.3
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15
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34247556914
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The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH
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An important negative study showing that overall GHRT does not have an effect on components of the metabolic syndrome
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van der Klaauw AA, Biermasz NR, Feskens EJ, et al. The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH. Eur J Endocrinol 2007; 156:455-462. An important negative study showing that overall GHRT does not have an effect on components of the metabolic syndrome.
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(2007)
Eur J Endocrinol
, vol.156
, pp. 455-462
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van der Klaauw, A.A.1
Biermasz, N.R.2
Feskens, E.J.3
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16
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34548141859
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Evidence for distinct effects of GH and IGF-I in the metabolic syndrome
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This study shows a positive correlation between IGF-1 and lipids, and a negative correlation with obesity. Sex difference is observed with IGF-1 significantly lower in women with the metabolic syndrome
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Maison P, Balkau B, Souberbielle JC, et al. Evidence for distinct effects of GH and IGF-I in the metabolic syndrome. Diabet Med 2007; 24:1012-1018. This study shows a positive correlation between IGF-1 and lipids, and a negative correlation with obesity. Sex difference is observed with IGF-1 significantly lower in women with the metabolic syndrome.
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(2007)
Diabet Med
, vol.24
, pp. 1012-1018
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Maison, P.1
Balkau, B.2
Souberbielle, J.C.3
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17
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33750502242
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Effect of growth hormone treatment on trunk fat accumulation in adult GH-deficient Japanese patients: A randomized, placebo-controlled trial
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Chihara K, Kato Y, Takano K, et al. Effect of growth hormone treatment on trunk fat accumulation in adult GH-deficient Japanese patients: a randomized, placebo-controlled trial. Curr Med Res Opin 2006; 22:1973-1979.
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(2006)
Curr Med Res Opin
, vol.22
, pp. 1973-1979
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Chihara, K.1
Kato, Y.2
Takano, K.3
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18
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34147126350
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A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults
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The longest prospective study looking at outcome measures with GHRT. It shows a sustained improvement in body composition and lipid profile, with more marked body composition changes in men
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Götherström G, Bengtsson BA, Bosaeus I, et al. A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults. J Clin Endocrinol Metab 2007; 92:1442-1445. The longest prospective study looking at outcome measures with GHRT. It shows a sustained improvement in body composition and lipid profile, with more marked body composition changes in men.
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(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 1442-1445
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Götherström, G.1
Bengtsson, B.A.2
Bosaeus, I.3
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19
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36849045260
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Oliveira JL, Aguiar-Oliveira MH, D'Oliveira A Jr, et al. Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naïve adults. J Clin Endocrinol Metab 2007; 92:4664-4670. This study on congenital GH-deficient patients showed an increase in the number of atherosclerotic plaques in patients receiving GHRT, suggesting a word of caution on the universally accepted beneficial effects of GHRT on atherosclerosis.
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Oliveira JL, Aguiar-Oliveira MH, D'Oliveira A Jr, et al. Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naïve adults. J Clin Endocrinol Metab 2007; 92:4664-4670. This study on congenital GH-deficient patients showed an increase in the number of atherosclerotic plaques in patients receiving GHRT, suggesting a word of caution on the universally accepted beneficial effects of GHRT on atherosclerosis.
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20
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35948943202
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Management of growth hormone deficiency in adults
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A comprehensive review on the management of GHD in adults
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Nilsson AG, Svensson J, Johannsson G. Management of growth hormone deficiency in adults. Growth Horm IGF Res 2007; 17:441-462. A comprehensive review on the management of GHD in adults.
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(2007)
Growth Horm IGF Res
, vol.17
, pp. 441-462
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Nilsson, A.G.1
Svensson, J.2
Johannsson, G.3
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21
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2442526224
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Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: A metaanalysis of blinded, randomized, placebo-controlled trials
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Maison P, Griffin S, Nicoue-Beglah M, et al. Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a metaanalysis of blinded, randomized, placebo-controlled trials. J Clin Endocrinol Metab 2004; 89:2192-2199.
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(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 2192-2199
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Maison, P.1
Griffin, S.2
Nicoue-Beglah, M.3
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22
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34548763034
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Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy
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Monson JP, Jönsson P, Koltowska-Häggström M, Kourides I. Growth hormone (GH) replacement decreases serum total and LDL-cholesterol in hypopituitary patients on maintenance HMG CoA reductase inhibitor (statin) therapy. Clin Endocrinol (Oxf) 2007; 67:623-628.
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(2007)
Clin Endocrinol (Oxf)
, vol.67
, pp. 623-628
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Monson, J.P.1
Jönsson, P.2
Koltowska-Häggström, M.3
Kourides, I.4
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23
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33947415737
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Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency
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Takahashi Y, Iida K, Takahashi K, et al. Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency. Gastroenterology 2007; 132:938-943.
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(2007)
Gastroenterology
, vol.132
, pp. 938-943
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Takahashi, Y.1
Iida, K.2
Takahashi, K.3
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24
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34147115747
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Atherogenic lipoprotein phenotype and low-density lipoprotein size and subclasses in patients with growth hormone deficiency before and after short-term replacement therapy
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Rizzo M, Trepp R, Berneis K, Christ ER. Atherogenic lipoprotein phenotype and low-density lipoprotein size and subclasses in patients with growth hormone deficiency before and after short-term replacement therapy. Eur J Endocrinol 2007; 156:361-367.
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(2007)
Eur J Endocrinol
, vol.156
, pp. 361-367
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Rizzo, M.1
Trepp, R.2
Berneis, K.3
Christ, E.R.4
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25
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35348812759
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Who needs to care about small, dense low-density lipoproteins?
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Rizzo M, Berneis K. Who needs to care about small, dense low-density lipoproteins? Int J Clin Pract 2007; 61:1949-1956.
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(2007)
Int J Clin Pract
, vol.61
, pp. 1949-1956
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Rizzo, M.1
Berneis, K.2
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26
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41649104293
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Postprandial alterations in LDL size and subclasses in patients with growth hormone deficiency
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Rizzo M, Trepp R, Berneis K, Christ ER. Postprandial alterations in LDL size and subclasses in patients with growth hormone deficiency. Growth Horm IGF Res 2008; 18:264-266.
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(2008)
Growth Horm IGF Res
, vol.18
, pp. 264-266
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Rizzo, M.1
Trepp, R.2
Berneis, K.3
Christ, E.R.4
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27
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2542466624
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Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals
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Randeva HS, Lewandowski KC, Komorowski J, et al. Growth hormone replacement decreases plasma levels of matrix metalloproteinases (2 and 9) and vascular endothelial growth factor in growth hormone-deficient individuals. Circulation 2004; 109:2405-2410.
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(2004)
Circulation
, vol.109
, pp. 2405-2410
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Randeva, H.S.1
Lewandowski, K.C.2
Komorowski, J.3
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28
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33646865444
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Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with growth hormone deficiency
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Gómez JM, Sahún M, Vila R, et al. Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with growth hormone deficiency. Clin Endocrinol (Oxf) 2006; 64:632-639.
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(2006)
Clin Endocrinol (Oxf)
, vol.64
, pp. 632-639
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Gómez, J.M.1
Sahún, M.2
Vila, R.3
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29
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33847122639
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Elevation of E-selectin concentrations may correlate with potential endothelial dysfunction in individuals with hypopituitarism during therapy with growth hormone
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Gómez JM, Sahún M, Vila R, et al. Elevation of E-selectin concentrations may correlate with potential endothelial dysfunction in individuals with hypopituitarism during therapy with growth hormone. Curr Neurovasc Res 2007; 4:55-62.
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(2007)
Curr Neurovasc Res
, vol.4
, pp. 55-62
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Gómez, J.M.1
Sahún, M.2
Vila, R.3
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30
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33947264873
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Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency
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Oflaz H, Sen F, Elitok A, et al. Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency. Clin Endocrinol (Oxf) 2007; 66:524-529.
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(2007)
Clin Endocrinol (Oxf)
, vol.66
, pp. 524-529
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Oflaz, H.1
Sen, F.2
Elitok, A.3
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31
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34047157587
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Obese adults with primary growth hormone resistance (Laron Syndrome) have normal endothelial function
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Schechter M, Ginsberg S, Sheinowitz M, et al. Obese adults with primary growth hormone resistance (Laron Syndrome) have normal endothelial function. Growth Horm IGF Res 2007; 17:165-170.
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(2007)
Growth Horm IGF Res
, vol.17
, pp. 165-170
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Schechter, M.1
Ginsberg, S.2
Sheinowitz, M.3
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32
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42049086543
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Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I
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This study demonstrates that the effects of GH on endothelial function occur independently of IGF-1
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Li G, Del Rincon JP, Jahn LA, et al. Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I. J Clin Endocrinol Metab 2008; 93:1379-1385. This study demonstrates that the effects of GH on endothelial function occur independently of IGF-1.
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(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1379-1385
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Li, G.1
Del Rincon, J.P.2
Jahn, L.A.3
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33
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33847039083
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Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulinlike growth-factor-1
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Thum T, Hoeber S, Froese S, et al. Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulinlike growth-factor-1. Circ Res 2007; 100:434-443.
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(2007)
Circ Res
, vol.100
, pp. 434-443
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Thum, T.1
Hoeber, S.2
Froese, S.3
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34
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0043246591
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Increased Interleukin-6 levels in pituitary-deficient patients are independently related to their carotid intima-media thickness
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Leonsson M, Hulthe J, Johannsson G, et al. Increased Interleukin-6 levels in pituitary-deficient patients are independently related to their carotid intima-media thickness. Clin Endocrinol (Oxf) 2003; 59:242-250.
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(2003)
Clin Endocrinol (Oxf)
, vol.59
, pp. 242-250
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Leonsson, M.1
Hulthe, J.2
Johannsson, G.3
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35
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0034682622
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Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial
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Sesmilo G, Biller BM, Llevadot J, et al. Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial. Ann Inten Med 2000; 133:111-122.
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(2000)
Ann Inten Med
, vol.133
, pp. 111-122
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Sesmilo, G.1
Biller, B.M.2
Llevadot, J.3
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36
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36248956034
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Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment of patients with acromegaly and growth hormone deficiency
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Andreassen M, Vestergaard H, Kristensen LØ. Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment of patients with acromegaly and growth hormone deficiency. Clin Endocrinol (Oxf) 2007; 67:909-916.
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(2007)
Clin Endocrinol (Oxf)
, vol.67
, pp. 909-916
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Andreassen, M.1
Vestergaard, H.2
Kristensen, L.3
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37
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33646026112
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Positive effects of a physiological dose of GH on markers of atherogenesis: A placebo-controlled study in patients with adult-onset GH deficiency
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Bollerslev J, Ueland T, Jørgensen AP, et al. Positive effects of a physiological dose of GH on markers of atherogenesis: a placebo-controlled study in patients with adult-onset GH deficiency. Eur J Endocrinol 2006; 154: 537-543.
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(2006)
Eur J Endocrinol
, vol.154
, pp. 537-543
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Bollerslev, J.1
Ueland, T.2
Jørgensen, A.P.3
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38
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33746370734
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Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis
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Abs R, Feldt-Rasmussen U, Mattsson AF, et al. Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis. Eur J Endocrinol 2006; 155:79-90.
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(2006)
Eur J Endocrinol
, vol.155
, pp. 79-90
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Abs, R.1
Feldt-Rasmussen, U.2
Mattsson, A.F.3
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39
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34548794192
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Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency
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A prospective study showing alterations in fibrinolysis in GHD patients, suggesting a possible mechanism for increased cardiovascular morbidity
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Devin JK, Blevins LS Jr, Verity DK, et al. Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. J Clin Endocrinol Metab 2007; 92:3633-3639. A prospective study showing alterations in fibrinolysis in GHD patients, suggesting a possible mechanism for increased cardiovascular morbidity.
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(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 3633-3639
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Devin, J.K.1
Blevins Jr, L.S.2
Verity, D.K.3
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40
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33750630132
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Changes in prothrombin and activated partial thromboplastin time during replacement with human recombinant growth hormone in growth hormone deficient adults
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Athens
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Miljic D, Miljic P, Doknic M, et al. Changes in prothrombin and activated partial thromboplastin time during replacement with human recombinant growth hormone in growth hormone deficient adults. Hormones (Athens) 2006;
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(2006)
Hormones
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Miljic, D.1
Miljic, P.2
Doknic, M.3
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41
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34250155671
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Pharmacologic therapy in growth hormone disorders and the heart
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A thorough review of cardiac function in patients with GHD and the effects of GHRT on cardiac function
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Climent V, Marín F, Picó A. Pharmacologic therapy in growth hormone disorders and the heart. Curr Med Chem 2007; 14:1399-1407. A thorough review of cardiac function in patients with GHD and the effects of GHRT on cardiac function.
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(2007)
Curr Med Chem
, vol.14
, pp. 1399-1407
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Climent, V.1
Marín, F.2
Picó, A.3
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42
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38349047822
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Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity
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Hartman ML, Weltman A, Zagar A, et al. Growth hormone replacement therapy in adults with growth hormone deficiency improves maximal oxygen consumption independently of dosing regimen or physical activity. J Clin Endocrinol Metab 2008; 93:125-130.
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(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 125-130
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Hartman, M.L.1
Weltman, A.2
Zagar, A.3
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43
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0034751043
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Baseline characteristics and the effects of five years ofGHreplacement therapy in adults with GH deficiency of childhood or adulthood onset: A comparative, prospective study
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Koranyi J, Svensson J, Götherström G, et al. Baseline characteristics and the effects of five years ofGHreplacement therapy in adults with GH deficiency of childhood or adulthood onset: a comparative, prospective study. J Clin Endocrinol Metab 2001; 86:4693-4699.
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(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4693-4699
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Koranyi, J.1
Svensson, J.2
Götherström, G.3
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44
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37349017937
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Bone quality: The material and structural basis of bone strength
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Seeman E. Bone quality: the material and structural basis of bone strength. J Bone Miner Metab 2008; 26:1-8.
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(2008)
J Bone Miner Metab
, vol.26
, pp. 1-8
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Seeman, E.1
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45
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34249825222
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Khosla S, Melton LJ 3rd. Clinical practice. Osteopenia. N Eng J Med 2007; 356:2293-2300.
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Khosla S, Melton LJ 3rd. Clinical practice. Osteopenia. N Eng J Med 2007; 356:2293-2300.
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46
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38649139894
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Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency
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Mazziotti G, Bianchi A, Cimino V, et al. Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency. Pituitary 2008; 11:55-61.
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(2008)
Pituitary
, vol.11
, pp. 55-61
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Mazziotti, G.1
Bianchi, A.2
Cimino, V.3
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47
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33751174502
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Bone mineral density in patients with growth hormone deficiency: Does a gender difference exist?
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Hitz MF, Jensen JE, Eskildsen PC. Bone mineral density in patients with growth hormone deficiency: does a gender difference exist? Clin Endocrinol (Oxf) 2006; 65:783-791.
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(2006)
Clin Endocrinol (Oxf)
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