Effect of growth hormone treatment on trunk fat accumulation in adult GH-deficient Japanese patients: A randomised, placebo-controlled trial

Current Medical Research and Opinion

Volumn 22, Issue 10, 2006, Pages 1973-1979

  Chihara, Kazuo ^a   Kato, Yuzuru ^b   Takano, Kazue ^c   Shimatsu, Akira ^d   Kohno, Hitoshi ^e   Tanaka, Toshiaki ^f   Irie, Minoru ^g  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d NATIONAL HOSPITAL ORGANIZATION KYOTO MEDICAL CENTER   (Japan)

^e FUKUOKA CHILDREN S HOSPITAL   (Japan)

^f NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^g TOHO UNIVERSITY   (Japan)

Author keywords

Abdominal obesity; GH deficiency; GH treatment; Trunk fat

Indexed keywords

HUMAN GROWTH HORMONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO;

ADULT; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; HYPERGLYCEMIA; JAPAN; LEAN BODY WEIGHT; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SUBDURAL HEMATOMA; TRUNK;

ABDOMINAL FAT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BODY COMPOSITION; DOUBLE-BLIND METHOD; FEMALE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIPIDS; MALE; MIDDLE AGED;

EID: 33750502242     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079906X132460     Document Type: Article

References (23)

1. Carroll PV, Christ ER, the Growth Hormone Research Society Scientific Committee. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J Clin Endocrinol Metab 1998;83:382-95
2. Shalet SM, Toogood A, Rahim A, Brennan BM. The diagnosis of growth hormone deficiency in children and adults. Endocrine Rev 1998;19:203-23
3. Bengtsson B-A, Eden S, Lonn L, Kvist H, et al. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1993;76:309-17
4. Larsson B, Svardsudd K, Welin L, Wilhemsen L, et al. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: follow-up of participants in the study of men born in 1913. Br Med J 1984;288:1401-4
5. Empana JP, Ducimetiere P, Charles MA, Jouveon X. Sagittal abdominal diameter and risk of sudden death in asymptomatic middle-aged men: the Paris Prospective Study. Circulation 2004;110:2581-5
6. Tomlinson JW, Holden N, Hills RK, Wheatley K, et al. Association between premature mortality and hypopituitarism. Lancet 2001;357:425-31
7. Beshyah SA, Johnston DG. Cardiovascular disease and risk factors in adults with hypopituitarism. Clin Endocrinol 1999;50:1-15
8. Bülow B, Hagmar L, Mikoczy Z, Nordstöm CH, et al. Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol 1997;46:75-81
9. Murakami Y, Yokoyama T, Oiso Y, Kato Y. Clinical features of adult hypopituitary patients in a national survey. In: Kato Y, editor. Annual report of the Japan Study Group on Hypothalamo-Pituitary Disorders. 2002. p. 170-6 [in Japanese]
10. Murakami Y, Kato Y. Hypercholesterolemia and obesity in adult patients with hypopituitarism: a report of a nation-wide survey in Japan. Endocr J 2003;50:759-65
11. Irie M, Itoh Y, Miyashita Y, Tsushima T, et al. Complications in adults with growth hormone deficiency - a survey study in Japan. Endocr J 2004;51:479-85
12. Ito H, Nakasuga K, Ohshima A, Maruyama T, et al. Detection of cardiovascular risk factors by indices of obesity obtained from anthropometry and dual-energy x-ray absorptiometry in Japanese individuals. Int J Obesity 2003;27:232-7
13. Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 1998;83:379-81
14. Shimatsu A, Fujieda K, Haniu K, Tanaka T, et al. Clinical study of measurements of IGF-I, IGF-II and IGFBP-3 using an IRMA kit. Report No 1. Study in adults. Horumon to Rinsho 1996;44:1129-38 [in Japanese]
15. Yoshiike N, Matsumura Y, Zaman MM, Yamaguchi M. Descriptive epidemiology of body mass index in Japanese adults in a representative sample from the National Nutrition Survey 1990-1994. Int J Obesity 1998;22:684-7
16. The Examination Committee of Criteria for Obesity Disease' in Japan, Japan Society for the Study of Obesity. New criteria for Obesity disease' in Japan. Circulation J 2002;66:987-92
17. Chihara K, Koledova E, Shimatsu A, Kato Y, et al. Adult GH deficiency in Japanese patients: effects of GH treatment in a randomised, placebo-controlled trial. Eur J Endocrinol 2004;151:343-50
18. World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation on Obesity. WHO Geneva: WHO Technical Report Series No 894; 1998
19. Ito H, Ohshima A, Ohto N, Ogasawara M, et al. Relation between body composition and age in healthy Japanese subjects. Eur J Clin Nutr 2001;55:462-70
20. Irie M, Shizume K, Takano K, Kato Y, et al. Growth hormone replacement therapy in adults with growth hormone deficiency: a double-blind, placebo-controlled crossover trial in Japan. Endocrinol Metab 1995;2(Suppl B):17-23
21. Chihara K, Kato Y, Kohno H, Takano K, et al. Efficacy and safety of growth hormone (GH) in the treatment of adult Japanese patients with GH deficiency: a randomised, placebo-controlled study. Growth Horm IGF Res 2006;16:132-42
22. Attanasio AF, Lamberts SWJ, Matranga AMC, Birkett MA, et al. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. J Clin Endocrinol Metab 1997;82:82-8
23. Kehely A, Bates PC, Frewer P, Birkett M, et al. Short-term safety and efficacy of human GH replacement in 595 adults with GH deficiency: a comparison of two dosage algorithms. J Clin Endocrinol Metab 2002;87:1974-9