Safety and efficacy of growth hormone treatment in small for gestational age children

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 15, Issue 4, 2008, Pages 376-382

  Poduval, Aruna ^a   Saenger, Paul ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Catch up growth; Growth hormone; Insulin resistance; Intrauterine growth retardation; Short stature; Small for gestational age

Indexed keywords

CHOLESTEROL; GLUCOSE; GROWTH HORMONE; HEMOGLOBIN A1C; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; HUMAN GROWTH HORMONE;

BIRTH WEIGHT; BODY HEIGHT; CATCH UP GROWTH; CHILD; CHOLESTEROL BLOOD LEVEL; DIET RESTRICTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSLIPIDEMIA; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HEMOGLOBIN BLOOD LEVEL; HORMONAL THERAPY; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRACRANIAL HYPERTENSION; INTRAUTERINE GROWTH RETARDATION; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; NOTE; PHARMACOGENETICS; POSTMARKETING SURVEILLANCE; PREMATURITY; RISK BENEFIT ANALYSIS; SHORT STATURE; SMALL FOR DATE INFANT; TREATMENT DURATION; DRUG TOXICITY; GROWTH DISORDER; GROWTH, DEVELOPMENT AND AGING; NEWBORN; REVIEW; TREATMENT OUTCOME;

BIRTH WEIGHT; BODY HEIGHT; DRUG TOXICITY; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; INSULIN RESISTANCE; PHARMACOGENETICS; TREATMENT OUTCOME;

EID: 55249115138     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e3283081911     Document Type: Note

References (53)

1. Ong KK, Ahmed ML, Emmett PM, et al. Association between postnatal catchup growth and obesity in childhood: prospective cohort study. BMJ 2000; 320:967-971.
2. Albertsson-Wikland K, Karlberg J. Postnatal growth of children born small for gestational age. Acta Paediatr Suppl 1997; 423:193-195.
3. Hokken-Koelega AC, De Ridder MA, Lemmen RJ, et al. Children born small for gestational age: do they catch up? Pediatr Res 1995; 38:267-271.
4. Karlberg JP, Albertsson-Wikland K, Kwan EY, et al. The timing of early postnatal catch-up growth in normal, full-term infants born short for gestational age. Horm Res 1997; 48 (Suppl 1):17-24.
5. Leger J, Levy-Marchal C, Bloch J, et al. Reduced final height and indications for insulin resistance in 20 year olds born small for gestational age: regional cohort study. BMJ 1997; 315:341-347.
6. Leger J, Limoni C, Collin D, et al. Prediction factors in the determination of final height in subjects born small for gestational age. Pediatr Res 1998; 43:808-812.
7. Ranke MB, Lindberg A. Growth hormone treatment of short children born small for gestational age or with Silver-Russell syndrome: results from KIGS (Kabi International Growth Study), including the first report on final height. Acta Paediatr Suppl 1996; 417:18-26.
8. de Zegher F, Albertsson-Wikland K, Wollmann HA, et al. Growth hormone treatment of short children born small for gestational age: growth responses with continuous and discontinuous regimens over 6 years. J Clin Endocrinol Metab 2000; 85:2816-2821.
9. Sas T, de Waal W, Mulder P, et al. Growth hormone treatment in children with short stature born small for gestational age: 5-year results of a randomized, double-blind, dose-response trial. J Clin Endocrinol Metab 1999; 84:3064-3070.
10. Ranke MB. Sensitivity to IGF-I in short children born small for gestational age. J Endocrinol Invest 2006; 29 (1 Suppl):21-26.
11. Leger J, Noel M, Limal JM, et al. Growth factors and intrauterine growth retardation. II. Serum growth hormone, insulin-like growth factor (IGF) I, and IGF-binding protein 3 levels in children with intrauterine growth retardation compared with normal control subjects: prospective study from birth to two years of age. Study group of IUGR. Pediatr Res 1996; 40:101-107.
12. Ackland FM, Stanhope R, Eyre C, et al. Physiological growth hormone secretion in children with short stature and intra-uterine growth retardation. Horm Res 1988; 30:241-245.
13. Albertsson-Wikland K. Growth hormone secretion and growth hormone treatment in children with intrauterine growth retardation. Swedish Paediatric Study group for growth hormone treatment. Acta Paediatr Scand Suppl 1989; 349:35-41; discussion 53-54.
14. Boguszewski M, Jansso C, Rosberg S, et al. Changes in serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 levels during growth hormone treatment in prepubertal short children born small for gestational age. J Clin Endocrinol Metab 1996; 81:3902-3908.
15. Chatelain P. Children born with intra-uterine growth retardation (IUGR) or small for gestational age (SGA): long term growth and metabolic consequences. Endocr Regul 2000; 34:33-36.
16. Czernichow P. Growth hormone treatment of short children born small for gestational age. Acta Paediatr Suppl 1997; 423:213-215.
17. Albanese A, Stanhope R. GH treatment induces sustained catch-up growth in children with intrauterine growth retardation: 7-year results. Horm Res 1997; 48:173-177.
18. Dahlgren J, Wikland KA. Final height in short children born small for gestational age treated with growth hormone. Pediatr Res 2005; 57:216-222.
19. Van Pareren Y, Mulder P, Houdijk M, et al. Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: results of a randomized, double-blind, dose-response GH trial. J Clin Endocrinol Metab 2003; 88:3584-3590.
20. Rosilio M, Carel JC, Ecosse E, et al. Adult height of prepubertal short children born small for gestational age treated with GH. Eur J Endocrinol 2005; 152:835-843.
21. Carel JC, Ecosse E, Nicolino M, et al. Adult height after long term treatment with recombinant growth hormone for idiopathic isolated growth hormone deficiency: observational follow up study of the French population based registry. BMJ 2002; 325:70.
22. de Zegher F, Albertsson-Wikland K, Wilton P, et al. Growth hormone treatment of short children born small for gestational age: metanalysis of four independent, randomized, controlled, multicentre studies. Acta Paediatr Suppl 1996; 417:27-31.
23. de Zegher F, Ong K, van Helvoirt M, et al. High-dose growth hormone (GH) treatment in non-GH-deficient children born small for gestational age induces growth responses related to pretreatment GH secretion and associated with a reversible decrease in insulin sensitivity. J Clin Endocrinol Metab 2002; 87:148-151.
24. Ranke MB, Guilbaud O, Lindberg A, et al. Prediction of the growth response in children with various growth disorders treated with growth hormone: analyses of data from the Kabi Pharmacia International Growth Study. International Board of the Kabi Pharmacia International Growth Study. Acta Paediatr Suppl 1993; 82 (Suppl 391):82-88; discussion 89.
25. de Zegher F, Hokken-Koelega A. Growth hormone therapy for children born small for gestational age: height gain is less dose dependent over the long term than over the short term. Pediatrics 2005; 115:e458-e462.
26. Zucchini S, Cacciari E, Balsamo A, et al. Final height of short subjects of low birth weight with and without growth hormone treatment. Arch Dis Child 2001; 84:340-343.
27. Coutant R, Carel JC, Letrait M, et al. Short stature associated with intrauterine growth retardation: final height of untreated and growth hormone-treated children. J Clin Endocrinol Metab 1998; 83:1070-1074.
28. Fjellestad-Paulsen A, Simon D, Czernichow P. Short children born small for gestational age and treated with growth hormone for three years have an important catch-down five years after discontinuation of treatment. J Clin Endocrinol Metab 2004; 89:1234-1239.
29. de Zegher F, Du Caju MV, Heinrichs C, et al. Early, discontinuous, high dose growth hormone treatment to normalize height and weight of short children born small for gestational age: results over 6 years. J Clin Endocrinol Metab 1999; 84:1558-1561.
30. Wilson TA, Rose SR, Cohen P, et al. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr 2003; 143:415-421.
31. Sas T, Mulder P, Hokken-Koelega A. Body composition, blood pressure, and lipid metabolism before and during long-term growth hormone (GH) treatment in children with short stature born small for gestational age either with or without GH deficiency. J Clin Endocrinol Metab 2000; 85:3786-3792.
32. Leger J, Garel C, Fjellestad-Paulsen A, et al. Human growth hormone treatment of short-stature children born small for gestational age: effect on muscle and adipose tissue mass during a 3-year treatment period and after 1 year's withdrawal. J Clin Endocrinol Metab 1998; 83:3512-3516.
33. Dos Santos C, Essioux L, Teinturier C, et al. A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone. Nat Genet 2004; 36:720-724.
34. Jorge AA, Marchisotti FG, Montenegro LR, et al. Growth hormone (GH) pharmacogenetics: influence of GH receptor exon 3 retention or deletion on first-year growth response and final height in patients with severe GH deficiency. J Clin Endocrinol Metab 2006; 91:1076-1080.
35. Pawlikowska-Haddal A, Cohen P. Advances in pediatric growth hormone therapy: IGF-I-based dosing. Indian Pediatr 2006; 43:577-581.
36. Cutfield WS, Lindberg A, Rapaport R, et al. Safety of growth hormone treatment in children born small for gestational age: the US trial and KIGS analysis. Horm Res 2006; 65 (Suppl 3):153-159.
37. Arends NJ, Boonstra VH, Mulder PG, et al. GH treatment and its effect on bone mineral density, bone maturation and growth in short children born small for gestational age: 3-year results of a randomized, controlled GH trial. Clin Endocrinol (Oxf) 2003; 59:779-787.
38. Hofman PL, Cutfield WS, Robinson EM, et al. Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab 1997; 82:402-406.
39. Sas T, Mulder P, Aanstoot HJ, et al. Carbohydrate metabolism during long-term growth hormone treatment in children with short stature born small for gestational age. Clin Endocrinol (Oxf) 2001; 54:243-251.
40. Veening MA, Van Weissenbruch MM, Delemarre-Van De Waal HA. Glucose tolerance, insulin sensitivity, and insulin secretion in children born small for gestational age. J Clin Endocrinol Metab 2002; 87:4657-4661.
41. Crowther NJ, Cameron M, Trusler J, et al. Association between poor glucose tolerance and rapid post natal weight gain in seven-year-old children. Diabetologia 1998; 41:1163-1167.
42. Soto N, Bazaes RA, Pena V, et al. Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. J Clin Endocrinol Metab 2003; 88:3645-3650.
43. Saenger P. Metabolic consequences of growth hormone treatment in paediatric practice. Horm Res 2000; 53 (Suppl 1):60-69.
44. Bluher M, Kratzsch J, Paschke R. Plasma levels of tumor necrosis factor-alpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance. Diabetes Care 2001; 24:328-334.
45. Levy-Marchal C, Czernichow P. Small for gestational age and the metabolic syndrome: which mechanism is suggested by epidemiological and clinical studies? Horm Res 2006; 65 (Suppl 3):123-130.
46. Van Pareren Y, Mulder P, Houdijk M, et al. Effect of discontinuation of growth hormone treatment on risk factors for cardiovascular disease in adolescents born small for gestational age. J Clin Endocrinol Metab 2003; 88:347-353.
47. Tenhola S, Martikainen A, Rahiala E, et al. Serum lipid concentrations and growth characteristics in 12-year-old children born small for gestational age. Pediatr Res 2000; 48:623-628.
48. Law CM, Shiell AW. Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature. J Hypertens 1996; 14:935-941.
49. Barker DJ, Martin CN, Osmond C, et al. Growth in utero and serum cholesterol concentrations in adult life. BMJ 1993; 307:1524-1527.
50. Dunger D, Yuen K, Ong K. Insulin-like growth factor I and impaired glucose tolerance. Horm Res 2004; 62 (Suppl 1):101-107.
51. Dietz WH. Critical periods in childhood for the development of obesity. Am J Clin Nutr 1994; 59:955-959.
52. Clayton PE, Cianfarani S, Czernichow P, et al. Management of the child born small for gestational age through infancy to adulthood: a consensus statement of the international societies of pediatric endocrinology and the Growth Hormone Research Society. J Clin Endocrinol 2007; 92:804-810. International consensus paper on management of SGA children.
53. Saenger P, Czernichov P, Hughs I, et al. Small for gestational age: short stature and beyond. Endocrin Reviews 2007; 28:219-251. Comprehensive review of metabolic consequences of being born SGA.