A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 22, 2008, Pages 6004-6006

  Brustad, Eric ^a   Bushey, Mark L ^a   Brock, Ansgar ^b   Chittuluru, Johnathan ^a   Schultz, Peter G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Alanine homologs; Cysteine homologs; Methionine homologs; Unnatural amino acids

Indexed keywords

ALANINE DERIVATIVE; AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; CYSTEINE DERIVATIVE; METHIONINE DERIVATIVE; MUTANT PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ESCHERICHIA COLI; HYDROPHOBICITY; MUTATION; NONHUMAN; PROTEIN DOMAIN;

ALANINE; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE; ESCHERICHIA COLI; HUMANS; LEUCINE-TRNA LIGASE; METHIONINE; MOLECULAR STRUCTURE; MUTATION; PROTEIN CONFORMATION; PROTEINS; RNA, TRANSFER; SUPEROXIDE DISMUTASE;

ESCHERICHIA COLI;

EID: 55249115067     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.050     Document Type: Article

References (19)

1. Wang L., Brock A., Herberich B., and Schultz P.G. Science 292 (2001) 498
2. Chin J.W., Cropp T.A., Anderson J.C., Mukherji M., Zhang Z., and Schultz P.G. Science 301 (2003) 964
3. Liu W., Brock A., Chen S., Chen S., and Schultz P.G. Nat. Methods 4 (2007) 239
4. Chin J.W., Martin A.B., King D.S., Wang L., and Schultz P.G. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 11020
5. Xie J.M., Liu W.S., and Schultz P.G. Angew. Chem., Int. Ed. 46 (2007) 9239
6. Guo J.T., Wang J.Y., Anderson J.C., and Schultz P.G. Angew. Chem., Int. Ed. 47 (2008) 722
7. Wang L., Zhang Z., Brock A., and Schultz P.G. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 56
8. Wang J.Y., Xie J.M., and Schultz P.G.J. Am. Chem. Soc. 128 (2006) 8738
9. Summerer D., Chen S., Wu N., Deiters A., Chin J.W., and Schultz P.G. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 9785
10. Wu N., Deiters A., Cropp T.A., King D., and Schultz P.G.J. Am. Chem. Soc. 126 (2004) 14306
11. Tukalo M., Yaremchuk A., Fukunaga R., Yokoyama S., and Cusack S. Nat. Struct. Mol. Biol. 12 (2005) 923
12. Boeke J.D., Lacroute F., and Fink G.R. Mol. Gen. Genet. 197 (1984) 345
13. Chen J.F., Guo N.N., Li T., Wang E.D., and Wang Y.L. Biochemistry 39 (2000) 6726
14. Liu Y.Q., Liao J., Zhu B., Wang E.D., and Ding J.P. Biochem. J. 394 (2006) 399
15. Mursinna R.S., Lee K.W., Briggs J.M., and Martinis S.A. Biochemistry 43 (2004) 155
16. Zhai Y.X., and Martinis S.A. Biochemistry 44 (2005) 15437
17. Zheng L., Baumann U., and Reymond J.L. Nucleic Acids Res. 32 (2004) 5
18. Aharoni A., Gaidukov L., Khersonsky O., Gould S.M., Roodveldt C., and Tawfik D.S. Nat. Genet. 37 (2005) 73
19. Jensen R.A. Annu. Rev. Microbiol. 30 (1976) 409