Reprint of "Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site" [Bioorg. Med. Chem. Lett. 18 (2008) 4554-4557]

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 22, 2008, Pages 6012-6015

  Torbeev, Vladimir Yu ^a,b   Mandal, Kalyaneswar ^a,b   Terechko, Valentina A ^a,b   Kent, Stephen B H ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Aspartic proteases; Chemical protein synthesis; HIV 1 protease; Ketomethylene isostere

Indexed keywords

AMIDE; ARGININE; CARBENE; GLUTAMINE; ISOLEUCINE; KETOMETHYLENE ISOSTERE; KETONE DERIVATIVE; NORLEUCINE; PROTEINASE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 55249111290     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(08)01314-0     Document Type: Article

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