Inhibition of a radiation-induced senescence-like phenotype: A possible mechanism for potentially lethal damage repair in vascular endothelial cells

Radiation Research

Volumn 170, Issue 4, 2008, Pages 534-539

  Igarashi, Kaori ^a   Miura, Masahiko ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2AX;

ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CELL AGING; CELL DAMAGE; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; IONIZING RADIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIVITY;

ANIMALS; AORTA; CATTLE; CELL AGING; CELL SURVIVAL; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR;

BOVINAE;

EID: 55249108953     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1423.1     Document Type: Article

References (17)

1. E. J. Hall and A. J. Giaccia, Radiobiology for the Radiologist, 6th ed., pp. 60-84. Lippincott Williams & Wilkins, Philadelphia, 2006.
2. G. M. Hahn and J. B. Little, Plateau-phase cultures of mammalian cells: An in vitro model for human cancer. Curr. Top. Radiat. Res. 8, 39-43 (1972).
3. J. B. Little, G. M. Hahn, E. Frindel and M. Tubiana, Repair of potentially lethal radiation damage in vitro and in vivo. Radiology 106, 689-694 (1973).
4. V. R. Jayanth, C. A. Belfi, A. R. Swick and M. E. Varnes, Insulin and insulin-like growth factor-1 (IGF-1) inhibit repair of potentially lethal radiation damage and chromosome aberrations and alter DNA repair kinetics in plateau-phase A549 cells. Radiat. Res. 143, 165-174 (1995).
5. N. Foray, A. Priestley, G. Alsbeih, C. Badie, E. P. Capulas, C. F. Arlett and E. P. Malaise, Hypersensitivity of ataxia telangiectasia fi-broblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int. J. Radiat. Biol. 72, 271-283 (1997).
6. L. Hayflick and P. S. Moorhead, The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961).
7. G. P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. E. Medrano, M. Linskens, I. Rubelj and J. Campisi, A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92, 9363-9367 (1995).
8. T. de Lange, Protection of mammalian telomeres. Oncogene 21, 532-540 (2002).
9. F. d'Adda di Fagagna, P. M. Reaper, L. Clay-Farrace, H. Fiegler, P. Carr, T. Von Zglinicki, G. Saretzki, N. P. Carter and S. P. Jackson, A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
10. B. D. Chang, E. V. Broude, M. Dokmanovic, H. Zhu, A. Ruth, Y. Xuan, E. S. Kandel, E. Lausch, K. Christov and I. B. Roninson, A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 59, 3761-3767 (1999).
11. K. Suzuki, I. Mori, Y. Nakayama, M. Miyakoda, S. Kodama and M. Watanabe, Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiat. Res. 155, 248-253 (2001).
12. M. Suzuki, K. Suzuki, S. Kodama and M. Watanabe, Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest. Biochem. Biophys. Res. Commun. 340, 145-150 (2006).
13. J-H. Chen, C. N. Hales and S. E. Ozanne, DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res. 35, 7417-7428 (2007).
14. K. Igarashi, I. Sakimoto, K. Kataoka, K. Ohta and M. Miura, Radiation-induced senescence-like phenotype in proliferating and plateauphase vascular endothelial cells. Exp. Cell Res. 313, 3326-3336 (2007).
15. E. J. Hall and A. J. Giaccia, Radiobiology for the Radiologist, 6th ed., pp. 30-46. Lippincott Williams & Wilkins, Philadelphia, 2006.
16. T. Stiff, M. O'Driscoll, N. Rief, K. Iwabuchi, M. Lobrich and P. A. Jeggo, ATM and DNA-PK function redundancy to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396 (2004).
17. D. R. Pilch, O. A. Sedelnikova, C. Redon, A. Celeste, A. Nussenzweig and W. M. Bonner, Characteristics of γ-H2AX foci at DNA double-strand break sites. Biochem. Cell Biol. 81, 123-129 (2003).