Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 22, 2008, Pages 5971-5974

  Turunen, Brandon J ^a   Ge, Haibo ^a   Oyetunji, Jariat ^a   Desino, Kelly E ^a   Vasandani, Veena ^a   Güthe, Sarah ^b   Himes, Richard H ^a   Audus, Kenneth L ^a   Seelig, Anna ^b   Georg, Gunda I ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Amides; Analogues; Blood brain barrier; Brain permeability; Cytotoxicity; log D; P glycoprotein; Paclitaxel; Polar surface; Succinates; Tubulin assembly; TX 67

Indexed keywords

AMIDE; ANION; CARBON; CARBOXYLIC ACID; ESTER DERIVATIVE; GLYCOPROTEIN P; PACLITAXEL DERIVATIVE; SUCCINIC ACID DERIVATIVE; TUBULIN; TX 67; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; BLOOD BRAIN BARRIER; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; PARTITION COEFFICIENT; STEREOISOMERISM;

BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CENTRAL NERVOUS SYSTEM; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; PACLITAXEL; STEREOISOMERISM; SUCCINATES; TUBULIN MODULATORS;

EID: 55249108189     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.103     Document Type: Article

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